一种circRNA、产品及其应用

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一种circRNA、产品及其应用

文档序号：3406 发布日期：2021-09-17 浏览：24次英文

一种circRNA、产品及其应用

技术领域

本发明涉及农业基因工程

技术领域

，具体涉及一种检测羊皮下脂肪的circRNA、产品及其应用。

背景技术

circRNA是最早发现于植物病毒以及流感病毒中的一类闭合环状RNA分子，经特殊剪切生成。circRNA不具5'帽子和3'多聚腺苷酸结构，相较线性RNA来说，由于核糖核酸酶不能降解circRNA，因此circRNA更加稳定。内源性竞争circRNA还可以影响miRNA活性，进而调控基因表达，推测circRNA可能通过以上原理对成脂分化进行调节。研究发现在前体脂肪细胞体外分化体系试验中有31种circRNA会随脂肪分化过程显著升高，相关性分析表明这些circRNA分子的表达可能与对应的线性RNA表达状态相关。有研究在对莱芜猪与大白猪皮下脂肪组织进行探索时发现，circRNA_26852和circRNA_11897可以靶向那些富集到与脂代谢以及疾病相关通路中的基因。CircACC1通过促进LO2肝细胞AMPK全酶组装、活性和稳定性，使脂肪酸β氧化得到促进。因此，推测circRNA有可能参与了脂质代谢的调节，并可以为脂代谢相关性疾病提供潜在靶点。

有关于羊皮下脂肪脂肪相关的研究目前较少，为了进一步发现新的与羊皮下脂肪相关的circRNA，发明人基于高通量测序技术，选取脂肪沉淀存在较大差异、具有代表性的多浪羊(D)与小尾寒羊(X)为研究对象，前者属于肉脂兼用型绵羊，脂臀较大，后者属于短瘦尾型绵羊，皮下脂肪较少，筛选鉴定出与脂代谢以及成脂分化关键候选基因，探究脂肪沉积相关的分子机制。

发明内容

本发明的首要目的是提供一种与绵羊脂肪相关的circRNA，所述circRNA是经过全转录组学测序筛选并使用分子实验验证获得的。

一种circRNA，序列与SEQ ID NO.1具有90％以上序列同源性。

优选的，circRNA序列与SEQ ID NO.1具有95％以上序列同源性；更优选的，长链非编码RNA序列为SEQ ID NO.1。

本发明的第二目的是提供一种产品，所述产品包括检测样品中上述circRNA的试剂。

优选的，所述产品包括芯片、试剂盒或核酸膜条。

优选的，所述试剂包括采用测序技术、核酸杂交技术或核酸扩增技术检测样品circRNA的表达水平试剂。

优选的，采用高通量测序技术、探针杂交技术、基因芯片技术或荧光定量PCR技术检测样品circRNA的表达水平。

优选的，试剂包括特异性识别circRNA的探针，或特异性扩增circRNA的引物。

优选的，所述特异性扩增circRNA的引物序列为SEQ ID NO.2和SEQ ID NO.3。

优选的，所述样品为脂肪组织，更优选的脂肪为皮下脂肪或肌内脂肪。

本发明的第三目的是提供上述circRNA在预测或辅助羊肉品质中的应用。

本发明的第四目的是提供上述circRNA在制备预测或辅助羊肉品质试剂中的应用。

本发明的第五目的是提供上述circRNA在选育具有不同肌肉品质羊中的应用。

所述肉用性能是指产肉量、胴体组成、肉中脂肪含量、肉品等级、脂肪色泽、肌内脂肪含量等方面的性能。

本发明的第六目的是提供上述产品在预测或辅助羊肉品质中的应用。

本发明的第七目的是提供上述产品在制备预测或辅助羊肉品质试剂中的应用。

本发明的第八目的是提供上述产品在选育具有不同肌肉品质羊中的应用。

本发明的第九目的是提供一种检测羊脂肪含量的方法，包括：(1)选取羊脂肪组织；(2)检测样品中上述circRNA的表达量。

优选的，脂肪为皮下脂肪或肌内脂肪

“多核苷酸”或“核酸”在本文中可互换使用，指任何长度的核苷酸聚合物，包括DNA和RNA。核苷酸可以是脱氧核糖核苷酸，核糖核苷酸，经过修饰的核苷酸或碱基，和/或其类似物，或者是可通过DNA或RNA聚合酶，或者通过合成反应掺入聚合物中的任何底物。如此，例如，本文中所定义的多核苷酸包括但不限于单链和双链DNA，包含单链区和双链区的DNA，单链和双链RNA，及包含单链区和双链区的RNA，包含DNA和RNA的杂合分子，它可以是单链的，或者更典型的是双链的，或者包含单链区和双链区。另外，术语“多核苷酸”在用于本文时指包含RNA或DNA或RNA和DNA二者的三链区。此类区中的链可来自相同分子或来自不同分子。所述区可包含一种或多种分子的整个，但是更典型的是只包含有些分子的一个区。三股螺旋区的分子之一常是寡核苷酸。术语“多核苷酸”明确包括cDNA。

多核苷酸可包含经过修饰的核苷酸，诸如甲基化核苷酸及其类似物。对核苷酸结构的修饰可以在装配聚合物之前或之后进行。核苷酸序列可以由非核苷酸组分中断。多核苷酸可以在合成后进一步修饰，诸如通过与标记物缀合。其它类型的修饰包括例如“帽”，将一个或多个天然存在的核苷酸用类似物替代，核苷酸间修饰诸如例如具有不带电荷连接(例如甲基膦酸酯，磷酸三酯，磷酰胺酯(phosphoamidate)，氨基甲酸酯等)和具有带电荷连接(例如硫代磷酸酯，二硫代磷酸酯等)的修饰，含有悬垂模块(pendant moiety)诸如例如蛋白质(例如核酸酶，毒素，抗体，信号肽，聚L-赖氨酸等)的修饰，具有嵌入剂(例如吖啶，补骨脂素等)的修饰，含有螯合剂(例如金属，放射性金属，硼，氧化性金属等)的修饰，含有烷化剂的修饰，具有经修饰连接(例如α端基异构核酸)的修饰，以及未修饰形式的多核苷酸。另外，通常存在于糖类中的任何羟基基团可以用例如膦酸基团，磷酸基团替换，用标准保护基团保护，或活化以制备与别的核苷酸的别的连接，或者可缀合至固体或半固体支持物。可磷酸化或者用胺或1-20个碳原子的有机加帽基团模块取代5’和3’末端OH。其它羟基也可衍生成标准保护基团。多核苷酸也可含有本领域普遍知道的核糖或脱氧核糖糖类的类似物形式，包括例如2’-氧-甲基-，2’-氧-烯丙基-，2’-氟-或2’-叠氮-核糖，碳环糖类似物，α-端基异构糖，差向异构糖诸如阿拉伯糖，木糖或来苏糖，吡喃糖，呋喃糖，景天庚酮糖，无环类似物及脱碱基核苷类似物诸如甲基核糖核苷。可用备选连接基团替换一个或多个磷酸二酯连接。并非多核苷酸中的所有连接都必需是相同的。多核苷酸可含有一处或多处不同类型的本文中描述的修饰和/或多处相同类型的修饰。前述描述适用于本文中提及的所有多核苷酸，包括RNA和DNA。

如本文中所使用的，“寡核苷酸”一般指短的，单链的多核苷酸，其在长度上小于约250个核苷酸，但这不是必须的。寡核苷酸可以是合成的。术语“寡核苷酸”和“多核苷酸”并不互相排斥。上文关于多核苷酸的描述同样且完全可适用于寡核苷酸。

如本文所用“引物”指能够与核酸杂交并允许互补核酸的聚合作用(一般通过提供游离的3’-OH基团)的单链多核苷酸。

本发明可以利用本领域内已知的任何方法测定基因表达。本领域技术人员应当理解，测定基因表达的手段不是本发明的重要方面。这些技术包括但不限于：核酸测序、核酸杂交、核酸扩增技术。

核酸测序技术的示例性非限制性实例包括但不限于链终止子(Sanger)测序和染料终止子测序。本领域的普通技术人员将认识到，由于RNA在细胞中不太稳定并且在实验中更易受到核酸酶攻击，因此在测序前通常将RNA逆转录成DNA。

核酸测序技术的另一示例性非限制性实例包括下一代测序(深度测序/高通量测序)，高通量测序技术是一种基于单分子簇的边合成边测序技术，基于专有的可逆终止化学反应原理。测序时将基因组的DNA的随机片段附着到光学透明的玻璃表面，这些DNA片段经过延伸和桥式扩增后，在玻璃表面形成数以亿计的簇，每个簇是具有数千份相同模板的单分子簇，然后利用带荧光基团的四种特殊脱氧核糖核苷酸，通过可逆性的边合成边测序技术对待测的模板DNA进行测序。

核酸杂交技术的示例性非限制性实例包括但不限于原位杂交(ISH)、微阵列和Southern或Northern印迹。原位杂交(ISH)是一种使用标记的互补DNA或RNA链作为探针以定位组织一部分或切片(原位)或者如果组织足够小则为整个组织(全组织包埋ISH)中的特异性DNA或RNA序列的杂交。DNA ISH可用于确定染色体的结构。RNA ISH用于测量和定位组织切片或全组织包埋内的mRNA和其他转录本(例如，ncRNA)。通常对样本细胞和组织进行处理以原位固定靶转录本，并增加探针的进入。探针在高温下与靶序列杂交，然后将多余的探针洗掉。分别使用放射自显影、荧光显微术或免疫组织化学，对组织中用放射、荧光或抗原标记的碱基标记的探针进行定位和定量。ISH也可使用两种或更多种通过放射性或其他非放射性标记物标记的探针，以同时检测两种或更多种转录本。

本发明可在检测前或与检测同时地对核酸(例如，ncRNA)进行扩增。核酸扩增技术的示例性非限制性实例包括但不限于：聚合酶链式反应(PCR)、逆转录聚合酶链式反应(RT-PCR)、转录介导的扩增(TMA)、连接酶链式反应(LCR)、链置换扩增(SDA)和基于核酸序列的扩增(NASBA)。本领域的普通技术人员将认识到，某些扩增技术(例如，PCR)需要在扩增前将RNA逆转录成DNA(例如，RT-PCR)，而其他扩增技术则直接扩增RNA(例如，TMA和NASBA)。

通常称为PCR的聚合酶链式反应使用变性、引物对与相反链的退火以及引物延伸的多个循环，以指数方式增加靶核酸序列的拷贝数；TMA的转录介导的扩增(在基本上恒定的温度、离子强度和pH的条件下自身催化地合成靶核酸序列的多个拷贝，其中靶序列的多个RNA拷贝自身催化地生成另外的拷贝；LCR的连接酶链式反应使用与靶核酸的相邻区域杂交的两组互补DNA寡核苷酸；其他扩增方法包括例如：通常称为NASBA的基于核酸序列的扩增；使用RNA复制酶(通常称为Qβ复制酶)扩增探针分子本身的扩增；基于转录的扩增方法；以及自我维持的序列扩增。

在本发明中，产品包括检测CIRCRNA的试剂，以及选自下组的一种或多种物质：容器、使用说明书、阳性对照物、阴性对照物、缓冲剂、助剂或溶剂。

本发明的试剂盒中还可附有试剂盒的使用说明书，其中记载了如何采用试剂盒进行检测，和如何利用检测结果对肿瘤发展进行判断、对治疗方案进行选择

本发明的优点和有益效果：(1)首次发现了序列如SEQ ID NO：1所示的circRNA及其与绵羊肉用性能相关；(2)在实际生产中，可以通过调控circRNA的表达，从而改善绵羊的肉用性能，提高肉感，因此本发明为畜牧业生产提供了理论基础和技术启示。

附图说明

图1为脂肪组织差异表达circRNA GO注释；

图2为脂肪组织差异表达circRNA KEGG通路富集分析；

图3为circRNA基因差异表达qRT-PCR验证结果。

具体实施方式

下面结合具体实施例，进一步阐述本发明，仅用于解释本发明，而不能理解为对本发明的限制。本领域的普通技术人员可以理解：在不脱离本发明的原理和宗旨的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由权利要求及其等同物限定。下列实施例中未注明具体条件的实验方法，通常按照常规条件或按照厂商所建议的条件实施检测。

实施例1样品的采集剂RNA提取

1.1样品的采集

本试验以脂肪沉积存在差异的多浪羊(D)与小尾寒羊(X)为对象进行研究。选取的羊只均为成年雌性，并且个体体况良好、健壮无病，体重相近(约50kg)，每组有三个生物学重复。

1.2样本RNA的提取和质量检测

取出各样品中等量的脂肪组织用作提取总RNA，确保整个流程在无菌环境下进行，步骤如下：

(1)分别在加有液氮的研钵里研磨脂肪组织；

(2)将研磨好的组织放入加有Trizol试剂的离心管中静置；

(3)加入氯仿混匀并在室温下静置10分钟；

(4)放入离心机中，在4℃条件下，转速12000，离心15分钟；

(5)将最上层无色液体放入RNase free管中，用等量异丙醇来沉淀RNA，室温下混合均匀静置10分钟；

(6)再次在温度为4℃、转速为12000条件下离心15分钟；

(7)将上清液去除，在沉淀中加入乙醇(75％)充分混匀后，再一次在上述条件下离心；

(8)去除上清液，继续加乙醇清洗RNA2-3次；

(9)弃乙醇，沉淀干燥处理5-10分钟；

(10)最后沉淀物用RNA无酶水处理。

为保证总RNA纯度及完整性，将其进行质量检测：

建库测序的要求是RNA总量不少于2ug，对longRNA(mRNA、lncRNA、circRNA)的文库构建采用TruSeqTM Stranded Total RNA Kit试剂盒，RNA总量为2μg，浓度在100ng/μL以上，OD260/280范围是1.8-2.2。

分别对多浪羊和小尾寒羊的6个皮下脂肪组织提取总RNA并进行质量检测，结果可见28S条带亮度相对于18S来说均显著较高；各样本RNA浓度高于200ng/μl；RIN值均大于8，OD260/280≥1.8，OD260/230≥1.0，说明RNA没有被碳水化合物和蛋白质等杂质污染，且完整性较好，可在后续试验中继续应用。

实施例2测序及数据分析

使用Illumina NovaSeq 6000测序平台测序。circRNA呈封闭的环形，由分别处在上游与下游的外显子剪接受体与供体位点反向连接而成，属于非编码RNA分子，RNA外切酶对其没有影响，更不易降解，所以更加稳定。线性RNA片段可以通过线性比对软件进行比对，但是处于环状RNA的反式剪切位置的Reads无法直接比对上基因组。基于Back splicejunction(BSJ)reads，利用相关软件(CIRI2+find_circ取并集)进行circRNA预测，并与数据库circBase(动物)进行比较。

根据circRNA在基因组上的起始点和终止点进行分类。第一类终止点和起始点均位于基因的外显子区域为exon circRNA。第二类起始点或终止点某一端位于基因的内含子区域为intron circRNA。第三类起始点或终止点某一端位于基因间区或当起始点和终止点均位于基因外显子区域，但两个外显子不在同一个基因上时，circRNA分类为inergeniccircRNA。

样本表达量差异分析。使用RPM(Reads per millon reads)，作为定量指标，计算公式为：

RPM＝Total exon reads/Mapped reads(Millions)

其中，Total exon reads表示某个样本Mapping到特定基因外显子上的全部reads；Mapped reads代表某个样本的全部reads总量。在多浪羊与小尾寒羊皮下脂肪组织中共得到18947个circRNA，对这些数据进行差异表达分析，(以|Fold Change|≥2.0，Pvalue<0.05为标准进行筛选)，在两品种羊皮下脂肪组织中共存在141个差异表达的circRNAs，其中有61个差异基因上调表达，80个下调表达。其中差异表达显著的circRNA——NC_040256.1_12467238_12540333是本申请首次发现，作为我们后续的候选分子中。

为了了解差异表达基因以及基因产物的功能，使用GO注释对差异表达基因进行三方面的注释分析，包括生物过程、细胞成分和分子功能。对差异circRNA的来源基因进行分析，发现共富集到379个条目，以Pvalue<0.01为条件筛选到了99个条目。如图1，差异表达circRNA来源基因在分子功能，主要富集在翻译抑制活动(translation repressoractivity)、瘦素受体结合(leptin receptor binding)、三磷酸酶活性(triphosphataseactivity)等条目；在细胞组分，主要富集在核糖核蛋白颗粒(ribonucleoproteingranule)、纤维状胶原三聚体(fibrillar collagen trimer)、核苷酸激活的蛋白激酶复合物(nucleotide-activated protein kinase complex)、细胞质核糖核蛋白颗粒(cytoplasmic ribonucleoprotein granule)；在生物过程，蛋白质激活级联(proteinactivation cascade)、质膜结合细胞投射组件(plasma membrane bounded cellprojection assembly)、囊泡细胞骨架运输(vesicle cytoskeletal trafficking)和TOR信号的调节(regulation of TOR signaling)等过程。通过GO功能研究发现，差异表达circRNA的来源基因通过调控瘦素受体结合酶、三磷酸酶等与脂肪沉积相关的酶活性调节参与到脂肪发育中来。

在多浪羊和小尾寒羊的皮下脂肪组织中，circRNA的来源基因共富集到110条通路中(图2，以Pvalue<0.05为条件进行筛选，共得到了3个显著富集通路，蛋白质消化吸收(Protein digestion and absorption)、胰高血糖素信号通路(Glucagon signalingpathway)和调节脂肪细胞中的脂肪分解(Regulation of lipolysis in adipocytes)。通过KEGG通路分析表明，差异表达circRNA来源基因在多浪羊与小尾寒羊皮下脂肪组织中参与到脂肪代谢相关的通路中，富集到通路中的差异基因可能对于两品种羊皮下脂肪沉积具有重要的调控作用。

实施例3实时荧光定量PCR检测验证

本实验分别收集20只多浪羊和小尾寒羊，在两个组之间对差异表达的circRNA进行PCR检测，每个基因3个重复，验证NC_040256.1_12467238_12540333基因差异表达情况。

主要方法如下：

用circRNA cDNA Synthesis Kit(GenePool，Cat#GPQ1805)进行反转录，反应体系为：2×FastSYBR Mixture，10μl；下游引物(10uM)与上游引物(10uM)各0.4μl；模板，2μl；灭菌蒸馏水至20μl。引物信息见表。

表1 PCR反应结果

反应结束后导出数据，用2^-ΔΔCt法计算样本相对表达情况，t-检验统计分析相对表达情况，数据显示为平均数±标准差(Mean±SD)，P＜0.05为显著。PCR数据分析及结果，利用2^-△△Ct法计算CIRCRNA基因在各个样本间的相对表达量，数据表示为平均数±标准差(Mean±SD)，P<0.05表示该基因在两组间差异显著。结果表明，NC_040256.1_12467238_12540333基因在小尾寒羊羊皮下脂肪组织中显著上调表达。

本申请通过功能注释及富集分析筛选得到与脂肪沉积紧密相关的circRNA基因，荧光定量PCR实验结果进一步验证了该结论。

序列表

<110> 中国农业科学院北京畜牧兽医研究所

<120> 一种circRNA、产品及其应用

<160> 3

<170> SIPOSequenceListing 1.0

<210> 1

<211> 73093

<212> DNA

<213> 人工序列(Artificial Sequence)

<400> 1

actcagtgac cttcgctgat gtggctgtgt acttcaccca ggaagggtgg actttactga 60

accccataga aatgtgatgc tggaaaacta caagaacctg accacaacag gtaaggctgc 120

catcattcca gtacactctt agggaacgga catatatgtg ctgtaccttc tgtgttccaa 180

gatgggtgat gccaatctga acacaatgga aactagtaga cactcgtatc taaggaatga 240

gttttactcc agtatccttt ctgtaacaat gtgctttgag aactaacagc attatcatga 300

ctcttgtttg aaatacgcat tctcaagagt tcacctgtgg cacagtgaat gaaactttga 360

aatttgggcc tagttatttc tgttttaaca agcaatggac attattctct tggacactgt 420

catttggcaa ccactagttt agcggcttct ccatgagacc aaacatctct tttacgttta 480

cttcatttcc tattttaata acattctcag tactttgtaa atgttcgtat acgtctgaac 540

atgttttcat gggccagaga tactatctct ttttagacac agaaagaggg gttgtttgcc 600

tttttatcta tttaaaaaat aggaccacat tcattctaga gacttgatta gatataggac 660

ctgatccatg ggaagttttg tcgtgtttgg caggtacttt ttcattaatg tatctttcct 720

tatgaacaag atatcaggca ttcaaaccca atctgatatc ttggttaaaa aaaagaaaag 780

ttgaagactg gagagacgaa tcctccaagg tgagagatta taaagaactt cccacgtcag 840

ttaaatttca gtgtgttttg ggtttataag aaggaaactt agtgagatgt tttccttcag 900

aaggctgagg acattggttt ctaatgctct gtaacttcct caacatctta tacatactta 960

cttttcattt tatcagagtt tcctatgatc tcaaaaaata gccttctgtt tctttatttg 1020

ttatgtcttt ttttttcctt tgggctatgt tggtcttcat cgttgtatat aggctcttag 1080

ttgctgtgtg caggctttcc gtagttgcag cggtcagggg ttcctctact tttggtgtgc 1140

aggcttccat tgggtagttt ctcttgttgc agagaatgag ctccagggcc tcagactcac 1200

tagttgcatc actcgggctc gacagtgcag gctcattagt cgtggcacac aggcttggct 1260

gttccagagc acatgcattt ttagtttcag gaccagggat ctcacatgtg acctctgcac 1320

tgtagatgag ttcttaacta ctggaccacc aggaaagtcc cttagtttta tcatgttgat 1380

gtatactttt tatccagaac tttccctaat agtattctct tttcctcatt ttcacttttt 1440

cataagactc atcgtttaaa tcaagtacta aattttgact acatatatat atatatattc 1500

ttaatttttg tcataatcaa gctcctcttt tctgtcttgc ctttttaaaa ggtatgttta 1560

gtttagaaac ttattcacat gagccttatt gtttttaact gctttaacat ccacttcttt 1620

ttgcagtctt aaatttatta ttctctttta ctttagaatg ggaaatgcaa attaaatcca 1680

atgacttgaa aattcagcag gatactttgc gggaaaaaat atcaaatagg gtacaaatgg 1740

taagatcagt aagttcataa gaaatatttc ttattttcct ttcagttaac gttgggattt 1800

cattacaaga tgaacactag tggtagatat ttgagtggca tttattccaa agatagcagt 1860

gtctgtcaac aaattttgat tatgttcaat ttggggatat cctaacctga ggttcaaagt 1920

agatgcatca gaattcctca agaaatcatt ctcacgtatg taattagact ttgaattttg 1980

agaacaattc aatgaaattg cagtgaactg ttttaccatt agagtatatg gcatttcatt 2040

gtgtcagaag gatttcatca tttaacttga aagaaatcaa cagaatagga actatatgaa 2100

tgtaatgaag atgttaaaaa tcatcatcat cattgtaatg atgtttctgt ttggagatgg 2160

ataggatcgg ttaatgagtc tgagaaagct ttgaatcatc atccattcat ttttccacag 2220

acacaaagcc acaatggaca ggaactgtat gactgtgagc gaagcaagaa agacatcagt 2280

gaccactttt accttaggac acacaggagc actgaaaatg gaaggaattt ttatgaagat 2340

aatcagtatg gaaagaactt ccatactcta cacaacaaac cctttactgg ggaaaaatcc 2400

cccatgttta atcagtgtgg aaaagctgtc aggctgactc cagatgttac acatatgaaa 2460

acacacactg gagagaaacc ttttaaatgt gacacatgtg aaaaagcctt taggttgttc 2520

tcattgattc atgttcactg ttgatttcat gctggaataa aaccttacaa atgtaaggaa 2580

tgtggaaaga actttgctgt attctcaaac ctcactggac atatgaaaac tcacactaga 2640

aagcaaccct ataaacgtaa agaatgtggg aaagacttcc atcgatcctc agacctcact 2700

ggacatctga aaactcacac tggagagaaa ctctatgaat ataaggaatg tgggaagctt 2760

ttgggtcatt gtcatacctt catgttcaca gtagaattca tgctggaata aaaccttata 2820

aatgtcaaga atgtgggaaa acctttactt tcccctcttg ccttattgaa catatgaaaa 2880

cgcacactgg agagaagcct tttaagtgtg acgcatgtgg gaaagtcttt gcatcttctc 2940

gtaatcttct tagacattta cgatctcata cagggcagaa gactgctaaa tgtgccagat 3000

gtgggaaagc atttgcttga tcctcacaag ttactcaaca tatgagaaca cacactggag 3060

agaagccttg taagtgtaac acatgtggga aagcctttca gttttccagt aatcttctta 3120

gtcatttacg atctcatact gggcagaaga ctgctaaatg tgacagatgt gggaaagtct 3180

tcactcaagt ctcagttctt actagatata tgaaaacaca catgggagag aagcctttta 3240

agtatgacac atgtgggaaa accttcactc taccctcata ccctcatacc tcatacctac 3300

ctcatacctc atacctcaac atatgaaaac acacactgga gagaaggttt ataagtgtga 3360

catatgtggg aaggtcttca ctcgatgctc ataccttact aaacatatga aaagacacac 3420

tggagagaag ctttgtaagt gtgacacatg tggaaaggcc ttcactgaat gctcagccct 3480

tactcaacat gtgacaacac acatgggaga gaagcctttt aactgtgaca aatgtgggaa 3540

ggcctatact gattcctcaa gtcttactaa acagtttaga attcacactg gagagaagcc 3600

ttttaagtgt gacaaatatg ggaaagcctt tgctgtttcc tcacatctta ctgagcattt 3660

tagaactcac actggagaaa gccttttgaa tgatatacgt gggaaaatat ttaccacttc 3720

ttcgcctgtt gggcttccct ggtagctcag atggtaaagc atctgcctgc aaagcaggag 3780

acctgggttc aattcctggg ttgggaagat cccctggaga aggaaatggc aatccactcc 3840

agcactcttg cctggaaaat cccatggacg gacgagcctg ataggctaca gtccatgggg 3900

tcgcaaagag tcggacatga gtgagcgact tcactttcac ttttcgcctg ttactgcaca 3960

caagcgaagg cacactggag agaaaccata tttgtgtaag gaacgtaggt aaaccttttt 4020

tgctcctcaa tgcttacttg ctatatacaa tgacattgga aaagaagtca ctgaaatgtg 4080

acaaatgtgg taaagccctt gttgattcct cctatcatac ttagcatttt atttttaata 4140

tttgactgca tctgcagcaa atgagacctc agttctctga caaaggataa aacccatccc 4200

cctgcattgg aatgcagagt cttgacctct gaacaaccag agaagtccca tactaaacat 4260

ttttgaactc aacataaaag agaatccttt tgagtgtaat aaatttcagt aagactcgcc 4320

aattcttcac cttttcaaat aatgaatgaa ataccaatta gcgttaatct gggattgcct 4380

catgaccatt ttttgctgac acagtgaaac cttgaccagg ttcgacgcag aaactgaaat 4440

tcatctattt gtacttctga tgtggcacag aagggcagag gattaggcac agctctactt 4500

tgtacaacat tgaataaatt accccactac ctcacaagaa agagtaaaga caatttaata 4560

tttatacatc cagtattttt cctctgtcct gtaactcttc tatcgacatc ctaagaccac 4620

ttgtgaaaga gagggaaaaa atatggtttg ctttaaaatc ataaaaatat ggtatcttca 4680

tatgataatc ttgatacaga aaaagccttt gacaaaatcc agcacccatt tatgattaaa 4740

aactcttcaa aaaaatggtc atagaaagaa cctacctcaa tatagaaaag accatacaaa 4800

tacacctaca gcaaacatta ttctcatggt gaaaagctga aagcattccc tctaagatca 4860

ggacaagaca agggtgtcca ctttcaccac tattattcaa catagttctg gaagtcctag 4920

ctacagcaaa cagagaagaa aaaaaaataa aaaaatccag attggaaaag aagaagtaaa 4980

aatctcactg tttgcaggtg acatgataca gtacacagaa aaccctaaag atagtattag 5040

aaaattacta ggactaacca gtgaatttag caaagttgca agatacaaaa tcaatacaca 5100

gaaatcactt gcattttgta ctaacaatga aaaatcagag aaattaagga atcaatccca 5160

ttcaccactg aaacaaaaag aattaaatat ctaggaataa gcttacctaa ggagacaaaa 5220

gaactgtaca cagaaaatta taagacactg atgaaagaaa tcaaagatga cataacagat 5280

ggagatattc catgtttctg gataggaaga atcaatgttt gtgaaaatga ctatactacc 5340

aaatggaatc tacagattca atgtgatccc tatcaaacac catgactttt tcacagaact 5400

agaacaaaaa aagtcacaat tcgtatgaaa aaacaaagac cctgaatagc aaaacagtct 5460

tgagaaagaa gaatggagct agagaaatca accttcctga cttcagatta tactacaaag 5520

ctacagtcat caagacggta ctggcacaaa aacagaagta tagaccaatg gaacaagata 5580

gaaatcccag aaataaaccc atgcacctat gggtacctta ttttttgaca aaggaggcaa 5640

gaatatacaa tggggcaaag atagcctctt caataaatgc tgctgggaaa actggaccac 5700

tacatgtaaa agagtgaaat tagaacactt tctaacacca tacacaaaga taaactcaaa 5760

atggattaaa gacctaaatg taagataagg agctataaaa ctataaagga agatctacaa 5820

aactataagg caagatcctc tgacccacct cctagagtaa tggaaataaa aacaaaaata 5880

aagtgagacc tgattaaact taaaatcttt gcacagcaaa ggaaactata gcaaggtgaa 5940

aagacaaccc tcagaatggg agaaaataat agcaaatgaa acaactgaca aaggatttcc 6000

aaaatataca agcagctaat acaactcaat gccagaaaaa caaaaaaccc aatcaaaagg 6060

tgggggaaag acctaaacag gcatttctcc aaagaagaca taaagatggc taacaaacac 6120

atgaaaagat actcaacatc actcattatt agagatgcaa atcaaaatta taatgagata 6180

tcacctcaca ccactcagaa tgaccatcat caaaatgtct acaaacaata aattctggag 6240

agggtgtgcg aaaagggaat gctcttgccc tattggtggg aatctaaatt gatacagcac 6300

tatggaagat tgtatggaga ttccttaaaa aactaggaat aaagctacca atatgaccca 6360

gaaatcccac tcctaggcac ataccctgag gaaaccgaaa ctgaaaaaga cacatgtatc 6420

ccattgttca ttgcactatt tacaatagct acaacatgga agcaatctag atgttcatca 6480

atggacgaat ggatataaaa gttgtggtac atatacacaa tggacgtaaa aggagcacat 6540

ttgagtctta aaaggagcca taaaaggagc acatttgagt cagttttaat gaggtggatg 6600

aacctagaat ctattataca ggtgaagtga gtcagaaaga ggaagataaa tatcatattc 6660

taatggatat atatggaatc tagaaaaatg gtactgaata agttattttc agggcagcaa 6720

tggagaagca gacatagaga gtagatttat ggacatggag agacgggagg agaggtgata 6780

tgtatggaga gagtaacatg aaaacttaca ttaccatatg taaaatagat agccaatagg 6840

aattttttgt atgtctcagg aaacccaaac aggggctttg tatcaaccta gaggtatggg 6900

atggggaggg agatgggagg aggttcaaaa gagagatgat atatatatac ctatggctga 6960

ttcatgttga ggtttgacag aaaaccacaa aatttctgta aagcaaatta tttcttcaat 7020

aaaaaattaa attaattttt aaaaatcatg gtttgagttt attatcagga cattcaatag 7080

gatctatttt tttctctaag gctacgtgcc agactgagac tcaaattaga acaaagtgtg 7140

ggatttgaat atttctcaca gaataaaggg atacaaaagt gaggacagaa atttctcagt 7200

gatgcatcaa atactgaatg tgagaagatt ctgttatctt tacagatact catttatgta 7260

aagaaaactg agtcaagcac aaagcaaatc gctaatttac tacatagaga cctaatatct 7320

atcttttact atacaccgtg tcttctacac tcatccttag cactgactct aatgcctgat 7380

accttctccc cacatgctat gacttcagtt taacatttta ccattgccca catattttaa 7440

agaggcccaa tactctctcc catctctcta taattaaccc tactcagttg ccatttgatc 7500

aagaatactc agggcttcct gggtagctca gctggtaaag aatctgcctg caatgcagta 7560

gactccagtt ctatacctag gttgggaaga tcccctggag aaaggataag ctacccactc 7620

catattcttg ggctttctgg tggctcagat ggtaaaagaa tctgcctgca atgcaggagg 7680

acctgggttc gacccctggg ttgggaagat cgcctggagg agggcatggc aaccccactc 7740

cagtgttctt gcctggagaa tccacatgta caggagagcc tggtgggcta caatacaaca 7800

gggtcacaaa gagtctgact tgactgagtg actaagcaca gtttagcaac caggatactc 7860

atcataaaag agggaattgg gaaaagaagc agtacatgtc acatttatgg tataagcata 7920

atgagccttg gttttccatg catcatgttc tttttttttc tttttttctc caatggtttc 7980

tttttttaat ttttgttttt gctttatttt actttacaat actgtattgg ttttgccata 8040

cattgacatg aatccgccac gggtgtacat gagttcccaa tcctgaaacc cccctcccac 8100

cttcccaccc catatcatct ctctggatca tccccatgca ccagccccaa gaatcctgaa 8160

atcctgaatc gaacatagac tggtgattca tttcttacat gatagtatac atgtttcagt 8220

acaattctcc caaatcatcc caccctctcc ctcttcctca gagtccaaaa gtcccgttct 8280

atacatcttg tgtctctttt gctgtctcac atgcctcaat gttctataga ttcatctttg 8340

tcattatcct agaatcttat ctcatctact caactatgaa aataacttca gtttaagtaa 8400

tacatttttg ggcttcctgg gtggtgctag tggtaaagaa cctggctgct aatgcaggag 8460

acataagaga cgcgggttca atccctgagt ctggaagatc ccctgaagaa gggccatgga 8520

aacccactcc ggttactctt gctcggggaa tcccatggac agaggagcct ggcgggatac 8580

agcccaaaaa ggtcaataag agtcgaacac gactgaagtg acttagcaca catgcacagt 8640

tatacatttt gctgtggaat gaattatttt tgatgcccaa aacccagtgt cttcctctca 8700

tttaggatga ggttttctgt gtggtgggca gtatctgaga ttctctcact gatccaaact 8760

cctggttttc ctacccctgt gtatttccct gccattgagt gcaagatgta cataaagacc 8820

cacttccaac aacaagaatg tgaaagaaat gtcgggaagt cattcttagc tggaacagag 8880

caaaataatc tggctctctt cttggtgttt tctctctggc attcttggtg ccttgcatta 8940

ataaaatcca actgcctcac caggaggtca catgtcaagg aactgaagga attctctgga 9000

caatattcca tgaagaagtg aatcctacca acagcctcat gagtgagctt gagagtggat 9060

atctgctgat ctaactttgt gatacctgca gcctgactga catcttgatt gcaacattct 9120

gggagatgca ctgaaatatt taaagtatca gtgagtaaat tataagtaaa gatcaatagt 9180

tttctaatat gccaatgtca atagagaaaa aaacttaaaa ctgaagactc atggtttggc 9240

agtggtttag ttgctaaatc atgtctgatt cttgtgaccc caagtgaaga ttcattaaaa 9300

ttagccaaaa aaaaaagaga gaagctatcc tttgagacaa atactaactg tgaaaatgga 9360

aagtatatca cattcttggt agagacctaa tactacatag atttcatgat tgatactact 9420

gatttgtaga tatcaaaata ataccattga gtggctaaat tggaggaggg agggtctgaa 9480

ttttatgtta agtacctgca agttagaagc aataagtaaa agtacaggtt aatttcctcc 9540

tgaggagaag aggggcccag atcattccta ggacattcat ttttctcctt tcctgttctg 9600

ttaatattat caagtctcca gagattggga taatgtggac cagcttgcta atgatgagtt 9660

ttggaagttg agccctaagg tcataccatt gtaaataact gggcagtgcc tctagctaat 9720

aatttgcctg ttctaatact gtgagtccac acctgtgtct cctcttcata ggaatctgca 9780

tcagaaggtc cagcctgagt ctgtctttca ctgcttcaac ctgaggagaa ggaccctgag 9840

actttatcac acaccaggca ggagagggtg agtgagtctg tgctccttgg tcatgctcca 9900

gcagagatgc agcccagccc ccgtaagtat tgagggagac agtgatcgaa ggacaaactg 9960

ttgggagcat tattccctcc acaagaggaa caaactgata ttttacttgg tagagaaatc 10020

tggagggcac cgatctgctc agttttcaaa tagagcactt aaaatctaca ttcgaggatc 10080

tgggctgggg tgtgagaact ctcattcaga gttctacttc caccaccact ggttctgact 10140

ctggctggaa atcccttccc accagaggag ctaatggact ctgtaacctt ccccctgaac 10200

acttcagttc attatgagag aagtgatgag gatgaagctg aggacaagga tgaagaatgt 10260

gacatcaacc ataacatcat gtactgttat gaccatagaa catcacagca tcatagatat 10320

ctggctctga agtgtttaca gtctggagga caagactaac aggtatataa aaaggcactc 10380

aacatcagtt aatatcagaa acacaggtcc aaaccagatc aaagatcacc tcataactgt 10440

taggatggct attaaaaaca atcaaaagaa aacaaatgct ggtgaggaag tggagagata 10500

agggaactgt tgtacattgt tggtgggaat gaatattggt accgtcgttg gagaaacaga 10560

atggatgttc tttaaaacgg tatttttcac agagctagaa caaataattt cacaatttgt 10620

atggaaatac cgaaaaactc aaatagccaa agcaatctta agaaagaaga atggaactgg 10680

aggaatcaac ctgcctgact tcaggctcta ctacaaagcc acagtcatca agacagtatg 10740

gtactggcac aaagacagaa atatacatca atggaacaaa atagaaagcc cagagataaa 10800

tccatacaca tatggacacc ttatcttcga caaaggaggc aagaatatac aatggagaaa 10860

agacaatctc tttcacaagt ggtgctggga aaactggtta accacttgta aaagaatgaa 10920

actagaatac tttctgacac catacacaaa aataaactca aaatggatta aaaatctaaa 10980

cggaagacca gaaactataa aactcctaga ggagaacata ggcaaaacac tctcagacat 11040

aaatcacagc aggatcctct atgacccacc tcccagaata ttggaaataa aagcaaaaat 11100

aaacaaatgg gacctgatta aacttataac cttctgcaca acaaggaaac tataagcaag 11160

gtgaaaagac agccttcaga atgggagaaa ataataccaa atgaagcagc tgacaaacaa 11220

ctaatctcaa aatatacaag caaatcctgc agctcaattc cagaaaaata aatgacccaa 11280

tcaaaaaatg ggccaaagaa ctaaatagac atttctccaa agaagacata cggatggcta 11340

acaaacgcat gaaaagatgc tcaacatcac tcattatcag agaaatgcaa atcaaaacca 11400

caatgaggta ccatttcatg ccagtcagaa tggctgagat ccaaaagtct atgagcaata 11460

aatgctggag agggtgtgga gaaaagggaa ccctcttaca ctgttggtgg gaatgcaaac 11520

tagtacaatt atggagaaca gtgtggatat tcctttaaaa actggaaata gaactgcctt 11580

atgacccagc aatcccactg ctgggcatac acactgagga aaccagaact gaaggagaca 11640

catgtacccc aatgttcatc gcagcactgt tgataatagc cagaacatgg aagcaaccta 11700

gatgttcatc agcagatgaa tggataagaa agctgtgata cagatacaca atggagtatt 11760

actcagccct taaaaagaat acatttgaat cagttctaat gaggtggatg aaactggagc 11820

ctattatacc aagtgaagta agccagaaag aagaacacca atacagtata ctaacacaca 11880

tatatatgga atttagaaag atggtaatga taaccctgta tgcgagacag caaaagagac 11940

acagatgtat agaacagtct tttgaactct gtgggagaag gcgaggatgg gatgatttgg 12000

gagaatggtg ttgaaacatg tataatatct attggatgaa tcgccagtcc agcttcgatg 12060

catgatactg gatgctttgg gctggtacac tgagacgacc cagagggatg gtacggggag 12120

ggaggagggc ggggggttca ggatggggaa cacgtatata cctgaggtag attcatgttg 12180

atgtatggca aaaccaatac aatattgtaa agtaattaac ctccaattaa aataaataat 12240

ttttttaaaa aaattttaac tgcaacaaat tgaaatagaa ctagaaacca gaaaccccac 12300

ttcagagtat tggccaagaa ataaaatcag accctcaaaa gtgagtattt gcattccctt 12360

gtctttgcaa tattatttga aatagtgaaa atatggatct gttgacagat aaataggtaa 12420

agaaaatgag atgtgtatat ataaacaatg ggatattatc tagccacaga aagaagaaaa 12480

tcctgccatt tttgacaaca tggatggacc tggaaaatac tgtgcttatt aaactatata 12540

taccagtcat agaaagtcaa atccactatg atctcagttc tgtgtggaag ctaagaaaat 12600

cacactcttg ttgtgaggat tggtggtaga aaaggtgagg aaatggtggt caaaatgcac 12660

aaacttttgt tacaaaatga gtaagtttgg ggatctaata tgcagcctga taactatagc 12720

taataattct ggttgtgttc ttgaaatctg ctgagagaga tctgcttaac tgttactaca 12780

cacacacaca caaacacaca catgcacgcg cgcacacaca cacacacatt cacagaagct 12840

atgtgaggta ccacatacat tatttaactt gactgtggta atcattccca atgtgtattg 12900

tattaaatca tcattttgta catcttttaa tgatctccat gcggcacaat tcaaatatat 12960

gaaattttgt caatcacttc agtaaactta agaaaataaa atcagtgaag tattattttt 13020

ctgccagtac agaatagagc ccccaaaggt aaagggtctc atccatcaaa catttaaatg 13080

agatggtatt gaaacaagta accctgttta agattaaaaa tttcaagagg atttcttttt 13140

tgttttttaa agaggatttc ttaaatttca ttattgtgtt atctttagca gtgctgtgta 13200

catgaacacc atctttatag tcaacaacac attagatcag gtacacttaa acaatattga 13260

tcgaaatttg aagtccacca aagtcaaaga tatgaaatat atatatacta aatgacttct 13320

aaaaaagctc tgatacttga ataatccctt atttcataaa ggagagaaga cagaaaaaca 13380

aaggatgata aaactctgag tatcatataa aatgagttct gattatgaac atcaccttta 13440

atttagaacc cagatgacat atctctgcat ttcatagaga tttataaata ttccaagtgg 13500

aggaaatatc tagaattgta tttgaataaa ataagattta tataaatgac ttaacttctt 13560

tatatttgca tttttacatg ctttcttaga agggaaaggg actctcattc tgtattatgt 13620

ctaaagaagt aggctgtctt taactgaggc catggatgta ttacctctaa tatccttcct 13680

ccctttcact tttcatgaag ctttataaca aatgtaagag agtatagaca gaagttaaaa 13740

acacagaaac caacaggaaa caattctaag aaaatagaat ttgtcacact gagaaatatt 13800

gctgaaggaa ctgggatgta taatctgaga aatgaattac ctgagtccaa aatatggaca 13860

cagtactgca tgaccattta tgtatttata tttttccagt cctcttttct tcttccgaag 13920

gtgtccaagc tacacagaac tggaaatcta acaagtgtct cagaattctt cctcctggga 13980

ctctcagatg atccagaact gcagcctttg ctctttatcc tcttcctgtc cgtgtacctg 14040

gtcaccatgc tggggaacct gctcatcatc ctggccacca cctctgaccc ccacccccga 14100

cccccacccc cacactccct tgtacttctt cctctccaac ctctccttgg ctgacattgg 14160

cttcagctcc accacggtcc ccaagatgat tgagaacatt caaactcaca gcagagtcat 14220

ctcctatgca ggctgcctga cacacatgtc tatttttata ctttttggat gtatggatgg 14280

tatgctgctg tctgtgatgt cctatgacag gtttgtggcc atctgtcacc cactgcacta 14340

cctggttatc atgaacccac acctctgttg ctccttagtt ttggtgtctt ttttttggta 14400

gccttatgga ctcccaggta cacaatctga ttgtgctgca acttacctgc ttcaaatttc 14460

taatttcttc tgtgaccctt ctctgctcct caagcttgcc tgttttgaca ttttcaccaa 14520

aaatatagtc atatatttta tcggtgccat ttttgctttt ctccctttct cagggatctt 14580

ttactcttac tataaaatta tctcctccat tttgagagtc ccatcatcag gtgggaggta 14640

caaagccttc tctacctgtg gctcacacct ggcagttgtt tgcttatttt atggaacagg 14700

tcttggtgcg tacctcagtt cagccatctc acaatctccc aggaaggatt cactggcctc 14760

agttatgtac actgtggtca cccccatgct gaaccccttc atctacagcc tgaggaacaa 14820

agacttcaaa agggccttgt gcaggttcct caacaaaaca atctaacttc catttggagt 14880

gtagattgga aaacgtagta aaattaacat ctagatctga aaattctacc tccctcatga 14940

catcagttgt agctcttagg gccttcttgc ctttccttgt tttacacctg aatattgctt 15000

ctttggatat gtttttgatg gggctaggag ggtcttctgg gattctgcag atgtcagaac 15060

tactgtgact gaatcttatt atacccaaga aggagtctag tttattatta ttatttatta 15120

ttgtggtgac ccacatacta gaaagatgaa caactccatt ttttacagat ttaaatagta 15180

tatttttttt tctaaagctg ttgtctattt tccagctgat tactatgttt taagtctgtg 15240

tatgcagtct acgtgtgagg atacatgtta tggcttctca gccttggctt ttaacaaaat 15300

aatctgggtg gggcgggggg cttacaaata ctgactattt tgcaacattg taattcaact 15360

atcctacaat aaaataaatt ttaaaaaata ctgtcaactg agactcactg ccaaagagtc 15420

tatttattct attcttattt atttttaaat gtattactta ttttaaagga ggaaaaatac 15480

ttcacaatgt taggttgtct tgaactgggg attttttaaa attccttata tctgttaatt 15540

tttgggcata acatgcagct tgtggggtct taattccaag accggggatt gaattcatgc 15600

ctcctgcatt caaagacaga atctaagcct ctgggccacc agggaagtcc cagcatgagg 15660

atttttaaac acactgaggc tggttctacc gtgtagccaa ggttgagaac ttctgatcta 15720

agtcagatct ttcagtcaaa tgtgaccttt atgtcatgtg tcctaactgc tcttggacaa 15780

atgtcccaga tcctaaagag atctgagctc atgggggaag atataaagag cctgctatag 15840

taacaggcaa catgcctgtg tgcatattca gtcagtaagt tgcacctgac tctctagtga 15900

tcccatggac tgtagcctgc caggctattc agtccatgat atttttcagg caagaatact 15960

ggagttgccc tttccttctc cgggggatct tcccgaccca aggatggaac ccacatctct 16020

tgaattggaa ggcatattct ttaccactgc acaacttgag aagccaaaca ggcaacatgg 16080

tttccccatt attgtcaata atgattcttc acatatagcc tctctacacc atagagtttg 16140

gtctctatgg cttatgtgct gtttctgaag ctattatctc tgctccaaac tcatgcttgt 16200

atacattgct ttggagtgtg actctggctt tggagtgtga ctctggaaat aaccgctcta 16260

ttttctattt tgtgttcatt ttacatacat tccatagtgg tcagtaaaat tctctttgcc 16320

ctaaattctc aactgttcct ttcatattcc tcaagccctt ggtggagtac aatctttctt 16380

cacccacaaa tgctatgcta ttgctttgtt cttttttttg cctgttagtc tttcagtatc 16440

ttttaaacca actccgtttc agttccattt agttcagtta ctcagtcgtg tctgactctt 16500

tgcaacccca cggactgcag cacgccagga ttccctgtcc atcaccaaca tccagagctt 16560

gctcaaactc atgtccattg agtcagtgat gccatccaac catctcatcc tctgccatcc 16620

ccttctcctc ctgccttcac tgtttcccag catcagggtc tttttcaatg agtcagttct 16680

tcacatcagg tggccaaagt attggagttt cagcttcagc atcagtcctt ccaatgaata 16740

gttaagactg atttccttta ggattgactg gtttgatatc cttgctgtcc aagggactct 16800

caagaatctt ctccaacgcc acatttcaaa ggtatcaatt ctttggtgct cagctttctt 16860

tatggtccaa ctctcacatc catacatggc tactggaaaa accatagctt ttggactata 16920

tggacctttg tcagcaaagt atgtctctgc tttttaatat gctgtctagg tttgtcacag 16980

ctcttcttcc aaagagcaag catcttttat catggctgca gtcaccatct gcagtgattt 17040

tggagcccag gaaaatagtt tatcactgtt tccattgttt ccccatctgc ttgccatgaa 17100

gtgatgggac tggatgccat aaccttcatt ttttgaatgt tgagttttaa gccaacctct 17160

tcactctcct ctgtcatttt catcaagagg ctctttatcc tcttcacttt ctgctctaag 17220

agcaatgtca tctgtatatc tgtggttatt gatactcctc ccagcaatct tgattccagc 17280

ttgtgcttca tccagcccag catttcacat agtatacttt gcatagaagt taaagaatca 17340

gggtgacaat atacagcctt aacatactcc tttaccaatt tggaaccagt ctgttgttcc 17400

atgtccagtt ctaactcttg cttcttgatc tgcatacaga tttctcagga ggctggtcag 17460

gtgttctggt attcccatct ctctaagaat tttccacagt ttgttgtcat ccacacagtc 17520

aaaggctttg gtgtagtcaa taaagcagta gtagatgttt ttctggaact ctcttgcttt 17580

ttctatgatc caacagatgt tggcaatttg atctctggtt cctctctgcc ttttctaaat 17640

ccagcttgaa catcaggaag ttcatgattc atgtactttt gaagcctggc taggagaatt 17700

ttgagcatta ttttgctagt gtgtgagatg agtgcaattg tgcagtagtt tgaacattct 17760

ttggcattgc ctttctttgg gattggaatg aaaactgacc ttttccagtc ctgtggccac 17820

tgctcaggtt tccaaatttg ctgcatattg agtgcagcac tttcatggca tcatctttta 17880

ggatttgaaa tagctcaact gatattccat cacctctact agctttgttc atagtgaact 17940

cccagtttaa attgccttaa ttaaaatgac taactggttt ttcctttctt ggctgaatct 18000

cagctaagta gcaagagaca taaaggtatg ctgtgaggta cctccaattg gaagattgca 18060

aaatgtgccc agggaataaa gcatatgtca agcgtatgtc ttagtttggg gtatgcacct 18120

gaaaaatagg cagtgatgtc ctagtccagt tgctgtgtgt ctctaatgat gcctgaggta 18180

cattgtcacc caagttttca cacttaattt atcttttttc acataatttt aggattgcaa 18240

agaactgtat tgtcaacaaa gagattttcc cctttactag aaatagcctg attaggactt 18300

cattactatg ctttcctgtc ttctgtcaca ggaaccctac gtcctagggt tcctattgtg 18360

ttctacaaga ttagtatcca tcgcgtctca gatgtgtcac acctgggttt tgtggaagta 18420

atcttggcca tccaaaagct gtgaaaaact agtttaattt actttgcatt ttgccactta 18480

ggaaaatcac tgactaactt tcttgttgag aaacttttat attaaagaaa acacttgaca 18540

cagactaaat tttaattagt ttggaggaag agatatcacc cagtaaaatt catgaaaatt 18600

acttgaatac tacatctgca tatccattta ggcaagccta agtgatagtg aaagaatatt 18660

ggaaaaaggc aaaggattgc tgcttttgtg tgtgggtggg tgggtgggtg gtttggtttc 18720

cagttcatgt tctgttaaat ttacacctcc tattttctta tagcatgcat gcatgttaag 18780

tctcctcagt tgtgtctgga tctttgcaac ccgatggact gtagcccacc aggttcctct 18840

gtccatggga ttttccaggc aagaatactg aagtgggttg tcatgccttt ctccagggga 18900

tcttcctcac ccagaaatcg aacccgcatc tcttatgtct cctattttgg caggcagctt 18960

atttaccact agagcctcag aagccccatt ttcttattaa atcatattaa attcttacag 19020

caaaaggaaa tttcaaaccc aaagttataa tagaaagcac acacctggat actaatccta 19080

gatgttctgc aacattcatg aaatattttt tcacaatata cacaattggt caaaggcgag 19140

aaaatacatt ctgtttctat gagaccaata atttatattc tatatataac aaataataca 19200

ttatacgtct ttcacagtat gacttatttg ttaccatgat gccctcaaat ttcacccata 19260

ttgtaccaaa tgacaggacc tgcttctttc tcataactga ataatattgt atgtactgaa 19320

tgtatatcac attttcttta tcccttatgc atccatggac actaggttgg tttcatcttt 19380

tgctctcgtg actgatgctg gaatgaacat ggccatgcag tcatttcttt gagagagtta 19440

tgtcatgccc tatggacaca cccagaagtg ggatcattgt agcatatggc agttctattt 19500

aacatttttg aggaacctcc gcactactgt ccatagtgct tatacagtcc catcagcagt 19560

gcatgaggat tccattttct acacattttt gccagcatgt tactttttgt ctttgtaata 19620

ataagcagtc taacaggtgt gaggtggaga tttgtcttcc tagtgttggg cctcaggctg 19680

aggtgtccaa tatatggtgc aaatctctca tccctacttc tcatagaggt taacccagcc 19740

cagtccctcc tcttctgtgt cccctcctga gggtatcaag tcactctcct ttcctaccca 19800

atttcatgtg gatcattctg ttttctttta atcttttttt aaaaattatt aaagtatagt 19860

tgatttataa tgttgtgcaa atctctactg tacagcaaag tgactgagtt atacacacat 19920

acacatttct ttctacattt tttaccatgt ggttcactct ttacagtctt ggtaaaagag 19980

tctctctgac agtttccagt tgttttcagt gagaatgact ccccatgtag atgcatttgt 20040

gttgttttcc tgcagggagc tgatctcagt gtccttttat tcccccatct tcacctcctc 20100

atagcaatgt atttaaattt atgcatgtgt gcgtttgctc agtcatatcc aactctttgc 20160

gaccccatgg acggtagccc accatgctcc gttatccatg ggattctcca ggcaggaata 20220

ctggagtggg ttgccatttc ctactccaaa atacatgtga gcatcttgca actcacgtgt 20280

tcccttatat taccaactgt gactgtgcgt gtgatacaaa acatcttttc aacttcctca 20340

tctataggag aatttcaaca aaatttctta actgagacag tggttgagac gagacaatca 20400

caggtactta tcagaacagt gtttggacac agtagtggat caagaagtgt acactatcat 20460

attcaccttg ttaataagcc agtattttgt ttcagctaaa aggtttttca ggtaatatat 20520

ttcatctgaa gcatcaactc ctggaagtca ttagcttgtg aaccagcaaa acacaaacaa 20580

actcttatgc tttccaacta tttttaacca catggaggtt aaagcactct agtttaaaag 20640

atggccttgg agagagtatc atggaagcag atacactacc atacgcaata tagatcccta 20700

atggaaatgt gctctatgac tcagggaact caaacttggg ctctataaca acctagaggg 20760

tggaaaagga agggaggtgg gagggaggtt cacaatggag gggatatatg tacacctatg 20820

gctaattcat gtagatgtat ggcagaaatc gaaacaatat tgtaaagcaa tcatcaagca 20880

atttaaaaaa ataaatgtaa ttaattttta aaagatgggc ttccccagtg gttcagtgat 20940

aagaaaccgc ctgccagtgc aggagacaaa ggtttgattt ctgggttgag aagatcccct 21000

ggataaggga atggcaaccc actctagtat tcttgcctgg ggaatcctat ggaaagagga 21060

gcctgatagg ctacagccct tggtgttgca gagttggaca tgacttagtg aataaacacc 21120

aataaccaca aattatttaa atgccccaac acccagtctc ttcctctcat atccacctgt 21180

gcatatcggc tatgtgatct ctcttaaaaa taccctgtca cttattcaca tacagttaaa 21240

taacattctt ctctccatat ccaatttgac ttggtttaaa gttttttcat gtcactggtg 21300

gctcagaggg taaagcatct gcctgcagtg tgggagacct gggttcgatc cctgggtcag 21360

gaagatcctc tgaagaagga aatggcaacc cactccagta ctcttgcctg gaaaatccca 21420

tggacggagg agcgtagtag gctacagtcc atggggtcgc aaagagtcgg acatgactga 21480

gagacttcag taatgacaaa tcaacctctg cattcatcag gagagcactc tccgtcagga 21540

agactgcatg gcaggactga gaaggttaca tcccaccact ctccacacac atcccacttt 21600

atccactagc aaaaaatggg taagccaaat ccacatttta ttaaagtctt caagagctga 21660

gaccacaagg aaaccaagag aaaacatacc caggtttgag tggatatcat tcgaatcagc 21720

agaaatcaga aacatgtgga acatatcatg cggaaacttg ttacatctgt tcacggagca 21780

gctacaggtt gtcctgatgc taatggaggg gctctcctag tataccataa accagcagtc 21840

tacttgagac tacatggcct gaagctatag agcagggtct gcagaagtac ccagtggaga 21900

ggaaggtcaa cccatttcta gtttgtttcc agggaatttt tgctgagatc atgttggtgc 21960

agtgaatcta ggaatatgct gcaaagcaga tgggcaagac atgactattg aagggtttgg 22020

agcacaaagt ccttatagag gatgaggcct gtgtggtgag caggacctta gatgctttca 22080

ctgatctcaa ctcctggttt tcattccact gtgtatttcc tcccatcaac tgtgagctat 22140

agtaaggaga tgaaagtacg ttatctgtag agacatttat taactctgaa aatggaaagt 22200

gtatcacatc attggtttac atctcttgcc acacagattt catgattgat acgatggatt 22260

ttcagctatc aaaaccacac tttgagtggc aaaattgagg ggggaaatgt gtaattttat 22320

gttaagatcc tgcaactttg aagtaaggaa caagagtaca tggaattacc tactaaagag 22380

aagagggaac cagacctttc caaggacatt cacttttctc cttttcctgt tctgttaata 22440

ttaacaagtc cccagagatg aggacaacat ggacctaatg atgagctttg tgcctcgagc 22500

tgtaaggtta tactatttta aataagtggc cagtgcctag agctctttag tttgccagtt 22560

ttgataccat gaatccacac ctatgtgccc atcctttata gcaatctgca tcagaaggtc 22620

cagcctgagt ctgtcttcct gctcaacctg aggagagact ctgagacttc atcacacacc 22680

aggcaggaga gggtgagtga gtctatgctc cttggtcatg ctccagcaga gatgcagccc 22740

agcccagtaa gtgctaggga gagagggatg gtgcagggaa tgttggaagc aatctatgca 22800

ggtttggaat aaagcacttt gaagttcata ttcttggttc tggttgagat gtgagaactc 22860

tcattcagag ttctgctttc accctcaatg gcctggctct ggctggcatc cctcccacta 22920

gagaagcaaa tgcacctctg taaacattcc ccttgttcag ttgtggttca gccactcagt 22980

tgtgtccaac tctttgtgga ctgcagcacg ccagtcttcc ctgtccttca ccatctccca 23040

gactttgctc aaactcatgt ccattgagtt gatgatgcca tccaaccatc tcatcctctg 23100

tcccccttcc cactaacact tcagttcatt acgggatcag tgatgaggat gaggacgagc 23160

atgatgagga tgatatgaac cataccatcc tgtcctgtta ttgaaggctt cctaggtgtc 23220

gggctctgaa gtataagttt tatatttcct tcttgagtac atctgcataa tttctctcca 23280

atcatatgta tacacattac tattatttta ataagaggaa agaagtgaaa tattttatgt 23340

aacatgtacc agtttatggg gctttcccgg tggcttagtg gtaaaaggat ctgcctgcca 23400

gtgcaggaga ctcaggatca agtcccgggt catgaagatc ccctggagaa ggaaatagca 23460

accgacccca gtgttcttgc ctgggaaatc acatggacag aggagcctgg cgggctacag 23520

tccttggtgt ctcaaagagt cagacacaac ttagggacta aacaatagca accagatcag 23580

gagttaaaga atgataaaat catgtttgaa gtcagtcatt ttggacagac tgattccaga 23640

tgcaaggtat gtgggcaatc ctctgccacc ccaaaccatc atgtcactca cttccctgtc 23700

agtcctggca gagactccct gctccctgct cactgttaca ggaacacttg tacttggttg 23760

gtgggaatga ataatgatac agccattgca gaaaacagaa tggaggttcc ttaaaaaaat 23820

taaaagctgc aactaattga aatagaacta ccataggatc tagcaaccca cttcagggta 23880

ggtgccaaag aaataaaatc agaacctcta agggatattt gcattccctt gtaatcatca 23940

tattacttga atagtgaaag tgtgtttatt gaagatgaat aggtaaaaga tgttgggtgt 24000

atatataaac aatgggatat tactcagcca taaaaaggac atcctgagat ttctgacaac 24060

atggaatgac ctggagaata ttatgcctat tttttaactc atttactata attggaggat 24120

aattacttta caatgttaca atggttcttg ccaaacatca ccaagaatca aaatttcaag 24180

agagttctta aattatatta tcatttactc attgacagat gattaataaa ggacaaaaat 24240

ggtatggacc taacagaagc agaaaatata atgaggtggc aagaatacac agaactatac 24300

aaaaaagatc ttcatgaccc agataatcag ataatcaccc agataatcac caaataatca 24360

tgacccagat aatcttcatg actcagatga tataatcact catctagagc cagacatcct 24420

ggaatgtaaa atcaaatggg ccttaggaag catcactatg aacaaagcta gtagaagtga 24480

tggaattcca attgagctat ttcaaatcct aaaagacaat gctgtgaaag tgctgcactc 24540

aatatgccag caaatttgga aaactcagca gtggccacag gactgaaaaa ggtcagtttt 24600

cattccaatc ccaaagaaag gtaatgccaa agaacactca aactactgca cagttgcact 24660

catctcatgc tggcaaaata atgctcaaaa ttctccaaac caggcttcaa cagtacatga 24720

accatgaact tccagatgtt caagctgaat ttagaaaagg caaagaggaa ccagagatca 24780

aattgccaac atctgttgga tcatagaaaa agcaagagag ttccagaaaa aaatatctac 24840

ttctgctttg ttgactacac caaagccttt gactgtgtgg atgacaacaa actgtggaaa 24900

attcttcaag agatgggaat accagaatgc ctgaccttcc tcttgagaaa catgtatgca 24960

ggtcaggaag caacagttag aactggacaa ggtacaacag actggttcca aataggaaaa 25020

ggagtacatc aaggctgtat attgtcaccc tacttattta acttctatgc agagtacatc 25080

atgagaaacg ctgggctgga tgaagcacaa actggaatca agattgccaa gagaaatatc 25140

aatcagctca gatatgcaga tgacatcacc cttatggcag aaagggaaga agaactaaag 25200

agtctcttga tgaaagtgaa agaggagagg gagaaagtgg gcttaaagct caacattcag 25260

aaaactaaga tcatggcatc cagtcccatc acttcatggc aaatagatgg aaaaacaatg 25320

gaaactgtga gattttattt tcaggggctc caaaatcaac gcagatggtg actgcagcca 25380

tgaaattaaa agatgcttgc ccctggaaaa aaaaaagcta agaccaacct agacagcata 25440

ttaaaaagca gagacattac tttgccaaca aaggtccctc tagtcaaggc tacggttttt 25500

ccagtagtca tgtatggatg tgagagttag actatcaagc aagctaatca ccaaagaatt 25560

gatgattttg aactgtggtg ttgaagaaga ctcttgagag tcccttggac tccaaggaga 25620

tccaaccagt ccatcctaaa ggagatcagt cctgagtgtt cattggaagg actgatgctg 25680

aagctgaaat tccaatactt tggccatctg atgcaaagag ctgactcttt tgaaaagacc 25740

ctgatgctgg aaaagattga aggtgggaga agtaggagac aacagaggat gagattgttg 25800

gatggaatca ccaactcaat ggacatgggt ttaggtaaac tccaggagtt ggtgatggac 25860

agggaggcct ggcatgctgc agtccatggg gtcgcaaaga gtcggacacg actgaactga 25920

actgaactga actgtatagc atagtgaacc cttctcaata ttctgtgaga ctaatttggg 25980

gaaaaaaatc taaaaaccag tggatatgta tgatgtataa ctgattcact ttcttgtaca 26040

cctgaaacta aaataccagt aaatcaactg tattccaata atttttaata atattcttta 26100

atatggcaat gtaattccat tagataaaaa ctcaaaaaca aagattcatt caaattagag 26160

ataaaaaatg taaatcttca tgatataaaa tgccattcta agcaaggagt aaagcaatga 26220

aaacaataat ttatacctag aggcaactaa ctgagaaaat ggaaagtgta tcacaccctg 26280

gtaaaaagtc ctaaaatgcc tagatttaat gataaataaa gagacttaca aatatcaaaa 26340

atcacacatt gtgtgattaa attgagaaaa aagtctgaat tttatgttat cctcctgcaa 26400

cttggaagta agaagtaaag cggagaggtg cacaaccacc tgaggagagg agggacattt 26460

ccaggacatt cacttttctc cttttccttt ctgtattaac aaatctccag agattgggat 26520

aacatggacc aactgactaa tgatgagctt tgggcattga gccctaaggt cataccatta 26580

aaaataattg gccagtgcct ccagctcttt agtttgcctg ttctaatatt gtgagtccac 26640

acctatgtct ccatcctttg taggaacctg catcagaagg tccagtctga atatgtcttc 26700

ctgcccatcc tgaggaggga ccctgagact tcatcacaca ccaggcagga gagggacagt 26760

gagtctgtgc tccttggtca tgctccagca gaaatgcagc ctagcccagt aagtgcagag 26820

ggagacagtg gttgacagcg ggactatttc agcattattt cctcctcaag agcaacaaat 26880

atgatagttt tcatagaaag gtaggaagac acccatctac atggttttgg aatagtgact 26940

tttgaaatat atgtatttgg ttctggttgg catatgagaa ctctcattca gagttctgca 27000

tacaccttac tggttctggt tctgactggc atccttccca tcagagcacc taatgggtct 27060

ctgtaaactt tctttcacac atttaaataa aatgaaatgg tgatgaacag atgatgaaaa 27120

tgaggaggat aaagctcatc ataacatcat gtactgttat tcaaggcttc ctaagtatca 27180

ggctctgagg cacgttttat gtttcttgct tgattctgtc tgcataatct ttcccaaatt 27240

attagtgcac acattattat tacttaaata agaggaaaga agcagagcat tttatgtcat 27300

atctaccact tcatgttaaa gtgttaaagc caagtctgaa gcctgtcaat ctgggcagac 27360

tgactccaga cacagagcat cagggcagac ttcccctttt cacccaaaca gtcctgtcac 27420

ttcctggcag agactccctg cttactgtgc ccttcccctt ggagttgtct ggagggcaca 27480

gtgttgggca ggtatcactt gccacatata ctataggaag aatgtctgag atcacagatg 27540

aagccataga aataactggc acctgatact ttagggtaga tctctgttga tgctgttctt 27600

tgatttcact tcacctgtcc actttctcct ctatagttag aatgagctaa gtcaatcatg 27660

aaggagacag aaaatcagtc ttagggccca gtcctattaa ggaaaatgaa aacatttaaa 27720

ataatgtact ccagatgtat ccatagttat acctctctac ctctgctgaa aactttcaga 27780

aagtctataa acaatgaaat ttagggcatg ggactcagag aagaaaaaca tttatttttg 27840

aatcctgttt gcttcactca ttcttagtgt actgtggggt aatttcttag aatctttgag 27900

atttaggatt atcaactgag ggattcctca ctaatacaga accactggat tgggactaag 27960

caaacaggct caccctcaat gcaataacta tgtgatggat gcaaaagaaa gggaaaaata 28020

catatttgat tttgttacta ataatgataa ggctatttgt catatcatca ggtttaaata 28080

tctctagatc tgatgttgtg gtttccttac atccctgaca ggacatttta gtttctacaa 28140

gtacattctt cctagactaa gagaactgag tgaggctcat ttatttctga ttccccaaaa 28200

cctgtatctt gttggtgcag aagagacacc aaggataaaa atgcccagtt aagtgttgaa 28260

taaactcttt ttttcatgga aacaacatgt gagcaatatg gtccacagag tggaccaatt 28320

atgtcagtgt tttcatcctt ttcagaaagt cccacaggtc tagagaaaag ttaaaacact 28380

ggttgtttct gtttcatggg cttcctttga gacttgttat tttccattta agagcatctg 28440

caacattcaa tcattgagaa gtcattgaag aaattttggt aaatatgggg agaaagagtt 28500

agaaaagaag aggacatgca cgttttattt cacgtgccta gccatatttt aggatttgat 28560

gttttctgtg ctccacctct gagataggaa aggctttgat ctctctgtca tatactccat 28620

gatacatcat tacattttgg gctttgcact taattaataa acatgcatgt gtactaagtc 28680

acttcagttg tgtccagcta tttgctaccc catggactgt ctcctgccag gcccctctgt 28740

caatggagtt ctccaggcaa gaatactgga gtgggttgcc aagccctcat ccaggggatc 28800

tttctgacct gcatctctta tgtctcctgc attggcaggc aggattttta ccactagcac 28860

ctcatggaaa gccctattaa taaacacatt atcccaataa tgattaaaaa tctttataca 28920

actgaccaaa tatttattgc ttccaactac cctctggtgc cacatgtatt ctagagtagg 28980

tgttagatct tcatgtccaa gaagagaagc acagagagcg tgagataatt gcacatattt 29040

cacttacaag gatgaaagac ccaggactct tatcactgat ctgctttttt ctgcaccagc 29100

tctcagtcat ctccactgta gctaatgtgt ttcttttcaa acctacttgg ctcccatagg 29160

tgataggaag gtagataatt acttcatcct cttttggttc agtgagaatc tgtgaatcat 29220

gggactgagg tcgcagttta cagaggtcat aatggcacta acatggatga ctgtaaggtt 29280

ttcagtgaat agtcatgcaa actgcagtcc agctttgaaa tttaaggttg agaagatttc 29340

ctatacaagg cgaaaatggc attggatgca gttgacagaa tattatattt gcactgaaac 29400

gagtacaggg aattagcttt cctggtggct cagacaacaa agaatctacc tgtgatgcag 29460

gaggcccagg tttgatccct gggttgggaa gattccctgc agaaggaagc ggcaacccac 29520

tccagtattc ttacgtggag cctggctcct ctgtatcctt acagaggagc ctggcgggct 29580

ccagtccatg gggtcgcatg gagtcagaca caactgagca cacacatacc aaactggtta 29640

tgcacccact gagagaactt aactaattac cactcacatg ttatgtacta atttccattt 29700

gtctgaaaca gagaaatgta cgagaatgtt cattggattg ttggaagcag gaactgatat 29760

aaataaaaat aacatatgca atgtaaacta aatatttatt taatatatca gttcagttca 29820

gttcagtcgc tcagtcatgt ccgactcttt gtgaccccat gaattgcagc atgccaggcc 29880

tccctgtccc tcaccaactc ctggagttca ctcagactca cgtccattga gtcagtcatg 29940

ccatccagcc atctcatcct ctgtcatccc cttctcctcc tgcccccaat ccctcccagc 30000

atcacagtct tttccaatga gtcaactctt cgcatgaggt ggccaaagta ctggagtttc 30060

agcttcagca tcattccttc caaagaaatc ccagggccaa tctccttcag aatggactgg 30120

ttggatctcc ttgcagtcca agggactctc aagagtcttc tccaacacca cagttcaaaa 30180

gcatcaattc ttcagcgctc agccttcttt acagtccaac tctcacatcc atacatgacc 30240

acaggaaaaa ccatagcctt gactagacag agcttagtcg gcaaagtaat gtctctgctt 30300

ttgaatatgc tatctaggtt ggtcataact tttcttccaa agagtaagtg tcttttaatt 30360

tcatggctgc agtcaccatc tgcagtgatt ttggagccca aaaaaataaa gtctgacact 30420

gtttccattg tttccccatc tatttcccat gaagtgatgg gaccagatgc catgatcttt 30480

gttttctgaa tgttgagctt taagccaact ttttcactct cctgtttcac tttcatcaag 30540

aggcttttta gttcctcttc actttctgcc ataagggtgg tgtcatctgc atatctgagg 30600

ttattgatta tttctcccag caatcttgat tccagcttgt gtttcttcca gtccagcgtt 30660

tctcatgatg tactctgcat agaagttaaa taagcagggt gacaatatac agccttgaca 30720

tactcctttt cctatttgga accagtctgt tgttccatgt ccagttcgaa ctgttgcttc 30780

ctgacctgca tacagatttc tcaagaggca gatcaggtgg tctggtattc ccatctctct 30840

cagaattttc cacagtttat tgtgatccac acagtcaaag gctttggcat agtcaataca 30900

gcagaaatag atgtttttct ggaactctct tgctttttca aaatatatca aattatatat 30960

tactgcactt aaatgtgtta aatttgttaa agtgaaatta atttatataa atttaccaac 31020

tgaagaaaat gctgtctctc cttatataat aatgtgtgtc agaaaattgt ttgatgtagt 31080

tgtatgtact tcacaagaga cttaaccaaa tggtgtggta atgaagtgca ttcagaggca 31140

gtatggatat tattttttta gggaagattt tttaaaagct ggttgtatgt gtgttagtca 31200

ctccatcttg tccaactctt tgcaccccca tggactgtag tccatgaggc tcctctatcc 31260

atggaattct ccaggcaaaa atactggagt gggttgccat ttccttctcc agggcatcta 31320

ccttacccag ggattgaacc caggtctcct gctttgcagg tggattcttt actgtctgag 31380

ctactacaga aaccctagaa gctggttatg ggtatgtaaa tgaatattga cattatgaaa 31440

acatttacaa gaaaacatat gtcaagttca tcacactggt tgctttgggg acgtgtatgc 31500

agggaagtgg gattgaactg aggttccaag agaagttaaa ttttatcatt aatgtttcaa 31560

atttctacaa tatgtgggat ctgaagaaat attattacat gtttatattt taagaataag 31620

tgtggtattc atgacagtat taatcaataa tattcatgga gacttttcta agtgttgggc 31680

aatattcatt ctgaggcagt gttgatcaag ccctggttca cagaagggag acagacactc 31740

atctatagag gtgctgaaat aggttctagg ctgaggtcag ggtaactaag catttttaaa 31800

taagcacatg taaataattg gtgaaatgga actgaaaatc actgctttaa tcaatataaa 31860

tgatttttta aaactttctt gcaatggtcc tattggtagg ttcaattact atcacaattt 31920

catagataag gaaactgctc agatgtgttt gcattattct atttaaatct ttttcacaac 31980

acactccctt gtcattgcaa tattttttga aatagaatat ggatatatgt ctgttgacag 32040

atgaacaggt aaagaaaatg tggagtgtat ataaacaatg ggatattact caggcatgag 32100

gggagataga gaggaatcaa catgaaccct gttaattttt tttgttctgt tacatttatg 32160

tttttaatta atttacttat tttaatggaa gataatttaa aaattgtgat ggtttttgcc 32220

atacatcgac atgaattggc caaaggtaca catgtacaac caacaaggac tttttgtata 32280

gtacagggaa ctctgctcaa tgttatgtgg tagtgtgaac ggaaggggat tttgagggag 32340

aatgggtaca tttatatgta tggctgagtt cctttgctgt ccgcctgaaa ctatcacaac 32400

attgttaact gactacaccc aatataaaat aagatttttt tttaataaga agtttttaaa 32460

aagagctgca gttgtgaggc ctagtggtgg agaaggtaga gaaatgttgg tcaaaggata 32520

taacttttgc taaaaaatga atatattctg gggatctaat atgcagtctg atgactataa 32580

ttaataattt catattgtgt tcttgaaatc tgctatgaga ggtttgttta ccttacacca 32640

caaacacgtg agcacaaata gaagttatgt aaggtgacat atacattaat tactttgatt 32700

gtggtagtca caatttgtat tgtagtaaat catcattttg tacaagtttt cataaactta 32760

tgtggcaaaa cccaaatata agcaattttg tcaatcactt caataaactg gaaaaaaaaa 32820

gaaaaacaat aaaggagtat tagttcacca gcaaagaatg gactccaaaa aatgtaaagt 32880

ggtctcacac attagacatt taactgagct ggtatgaaaa caaacactgt atacgattaa 32940

aaaaaaaaat ttcaagaacg tttctaaaat ttcattatca tttaatcatt gacaatgctc 33000

tgtatgctaa tgtcataatt atagtaatta attctgtatg atcacgtgcg ctgaattaaa 33060

ccatacagat caaattttta agtccaccaa agtcaaatga agtatatact aaatgatttt 33120

ttaaatgcaa ccctgataag tgagtaatca cttatttcat gaaggaggga agacaggaaa 33180

accaataata aaactctgaa tatcacttaa atatgttttc tgattgtaaa cattcatttt 33240

tagtttagaa tccagatgaa caatttcttc atttcataga gatgtaaaaa tattccaaat 33300

aaaggaaata actagaattt aatttaaata agatttatac aaatatgttt aatttctttg 33360

aattatattt tttcttaaag gaggaaggga atttctcttt ctgtattatt tctaaagaag 33420

taggctgtat ttaactgaga tcatagatat taattccaat gttcttgtcc cctttcactt 33480

ttatgtggag ttttataatc taagagtttg tagacagatg tgtctaacag aaaccaagga 33540

ggaaaaattc taagcaaata gaatttgtca tagtgagaaa tattgctgga ggaacaagag 33600

tgtataatct tagaaataaa ttgcttgaat ccaaaatatg gacacagtct caacgcccgt 33660

ttacttattt cctttgtttc cagccctgtt tcctttttcc aaaggtgtct gagatacaca 33720

gaactggaaa tttaacaagt gtctcagaat tcttcctcct gggcctctca gatgatgcag 33780

aactgcagcc tttgctctgt gtcctcttcc tgtccatgta cctggtcacc gtgttgggga 33840

acctgttcat catattagcc gtcacctctg acccctgcct ccacaccccc atgtacttct 33900

tcctctccaa cctgtcctcg gttgacatag gtttcatctc caccagagtc cccaaaatga 33960

ttgtggacat ccaatctcaa agcagagtca tctcctattc aggttgcctg actcagatgt 34020

ctatttttat cctttttgca cgtacggatt gtatgcttct tactgtgatg cctatgacag 34080

atttgtggcc atctgtcacc cactgcacta cattgtcatc atgaacccat gcctgttttg 34140

ctccttagtt ttggtgtcct tttgtgttag ccttttggac tcccaggtgc acaatgtgac 34200

tgtgttacaa cttacctgtt tcaaggatgt agaaatttct agtttcttct gtgacccttc 34260

tcaaccgctc aaccttgctt gttctgacac tttcaccaat aacatagtca gctatactat 34320

ccgtgccttg actggttttc tatctcagga aacattttct cttactataa aattcttgtc 34380

tccattctga gagtcccctc atcaggtggg atgtacaaag cctttgccac ctgtggttct 34440

catctggcag ttgtttgctt attttatgga acaggtcttg gtgtgtacct cagctcagcc 34500

atctcacaat ctcccaggaa ggatgcagca gcctcggtgg tgtacactgt ggtcaccccc 34560

atgctgaacc ccttcatcta cagcctgagg aacaaagaca tccaaagggc cctgtggagg 34620

ttcctggtag cacaaactca acttaggacc ttcgcaaccg atttgcatgt atactaaaaa 34680

atgtagcaaa actaaacctg gagatctaaa aattccacct ctctcatgac accattttta 34740

tagctcttat ggacttcatg tctctcctca ctttctacct gaatattact tctctttacg 34800

gtttatcccc ctgccagtgc aggagacaca agaaacacag gtccaatccc tgagtctgga 34860

agatccctgg aggaggaaat ggcaacccac tccagtattc ttgcctttga aatcccatgg 34920

acagagaagg ctggtggtct acagtctgca gggttgcaaa gagtcaaaca agactgagca 34980

catgcaaaca cacatggttt aacatgacag tggggaattc taagagtctt ttgtatcaaa 35040

atcactcctt gaatgaatct cattaatatc tatggagatt ctatatttta tctttggtag 35100

cccacgcatc ctcaaaagat gaataattct ccaggcaaga acactggact gggttgccat 35160

ttccttctcc aaggcatgaa agtgaaaagt gaaagtgaag tcgctcagtc atgtctgact 35220

cttcatgacc ccatggactg cagcccacca ggctctgcca tccatgggat tttccaggca 35280

agagtactgg agtggggtgc cattgccttc tccggtggag aagtttagaa gacttaaatc 35340

tgttccagag aaggctttga agagaagggg cttatttggt tttatgataa gagggaagag 35400

gtaagagaaa aataatattc aatatttcat gagtttcact ctgtgtcatt cacagaattg 35460

tggagccata cattgcttca tcagttcagt tcagttcagt tcagtcgctc agtagtgtcc 35520

aactctttgc aaccccatga actgcagcac gccagaggta cccaaatctg aagtccgtaa 35580

aaagcatggt tatggaaaaa tcagcaagaa gcaaatttcc ctgacaggta acgtgttgat 35640

tgctcgatct cttgggaatg tatggctcca caactctcag catgttaact gaagccttgc 35700

tgagcttcac aaaggtgcta ttgaagatct gccggaggcg aaggagctgt agcacctttt 35760

gaacctttgg gccacgctgt tgacacctct gatcctgacg acaaatgcca atttgggttc 35820

tgcaggtaca tagaagttgc cagctttttg ttccatccta gccattcgaa tttcagttct 35880

gtacatctgc atgtattcct tgcggtaatg cttagctttt tcatagacaa gcttcctcct 35940

tgcctttcaa agcatctttt gggcaaactt ctttctcagg tgcttaatct taagctctgt 36000

gaaattcttt tgctttttct taggggtttc aggcacagta ggaacctcct ttttttttct 36060

cttctgcaca tttcatggtt ccagctggaa aagaggtatc tcaaaatttg tgtgtgtgaa 36120

gagtaaatac gttggagcta taaagtttca aagagttccc tgcacagagt aacaaacagt 36180

tcaataaacc ataactattt cagtggaatc aaactattaa tatgcatata ttgctaacaa 36240

tgagctgtac gtattggtct catatttttt tttttttatc tttattggag tatagttact 36300

ttacaatgtt gtattagttt ctactataca gaaaaatgaa tcagttatac atgtacatac 36360

ttccttccca ttcaggtcac cacagtgcat taagtagagt tccctgtgct atacagtagg 36420

ttatctattt tatacacagt ataagtagta tatatgtgtc aatatcagtc tcccaattcc 36480

tcccacccca tcgtttcccc ttggtatcca tatatttgtt ctctacacct gtgtctctat 36540

ttctgctttg caaatatcta tactattttt ctagatttca tatatatgaa ttaatataca 36600

atatttgctt ttctctgact tacttcactt tgtatgacat tctctaggtc catcaatgaa 36660

cactggggtg catgtgtctt tttcaattag gtcttatact ttattaaatg gattctttcc 36720

ttccctgtaa ccacactcct tccgtaagat aaggagttca tattctgtgg ataattggaa 36780

agatatctgg agcttgccta gaagatggca agtgaaggtc actccaaaat gctgtctcag 36840

tctcagctga ccctagcagt tccctgtcta accacaaata agcctgcttt ctctaactgg 36900

ttcttcagaa ttctttggtc actggaggca atatagtata gttataaaaa tcatgcactc 36960

tgaattcaga cgtagtttca ctacatgtat aacaccggcc aattatttga gctcatgtgt 37020

gctgtttcac tatttgtgtc aagtggataa gtatctgcct cataaacttt ttgtgacaat 37080

caaaaagatt aatatataga aatatcttga gtattaagat agtgaatgat acagagtgaa 37140

actcatgaaa tattaaatat tatttttctc ttacctcttc cctcttatca taaaaccaaa 37200

taagcccctt ctcttcaaag ccttctctga aacaatttaa gtcttctaca cttctccacc 37260

agagaaggca atggcacccc actccagtac tcttgcctgg aaaatcccat ggacggcaga 37320

gcctggtggg ctgcagtcca tggggttgtg aagagtcaga cacaactgag cgacttcact 37380

ttcacttttc actttcatgc cttggagaag gaaatggcaa cccagtccag tgttcttgcc 37440

tggagaatcc cagggatggg ggagccgggc gggctgctat ctatggggtc acacagagtc 37500

ggacacgact gaagtgactt agcagcagca gcagcaatag caaacttctc aacggtatgg 37560

gacatgggta tggccccatg gcatgtgaca tcttagttcc aatggtatta gttccctgac 37620

cagggatcaa acctacaccc ccatcattgg aggcacagag tcttaaccac tggaccacca 37680

gggaagtcct tgagaaggaa gtgtttctga tagcacagaa aggatgcagt cccaccccgg 37740

ccactgcagt agcacttcct atgtgcattt ctgatacact aaactaagga ccagaaagct 37800

taaatgactt ttttctaagg tcacagaggt aataagttga aaagtgaaga ctagaaatca 37860

ggtgtcttgg ttcccagacc agttttcttt tcattccaac aagaaaaccc tgtgacctta 37920

tgacaatagg caacataaag gtgtttctct gcatacatct caaatgcatc gcaactgata 37980

atagtagaat attctgatgg gatggttcta taagcaaact acacaaaaca taagacaagc 38040

agtgacataa gcatctatca caactagcta ggaaaatatg agaaaattaa acccaaattc 38100

agtagaagga ataagaccaa aaattaaaga attataagta gaataaaact gagagtttgt 38160

tcttcaaaaa caattaaaat atctaaatcc ctaccaagat gaagaaaagg gggactacat 38220

aaattaccaa gatcaggaat gaaaaaggag atattattat cattacagct tttagacatt 38280

aaaaataaat tataggactt tattaataac tttagaccga caaatttgga aagttatgga 38340

atggacagat acaatatagc aaaacaaaca caaattttat ataatctttg tctatttata 38400

cattcaatat aaatcaccac tggagtagga aatggcaacc cactccagaa tccttgcctg 38460

gaaaactcca tgaacagtgc cacctggcag gctacagtcc atggggttgc aaagagttgg 38520

acaaaactga gcattacaca cacacacaca aatttaccag taaaactatt ttacaaaagc 38580

ttcctgtcaa gaaaacccaa atatagattc cctggtgaac ttttccaaac atataagtaa 38640

tagatataga tagttcagat ttcatataaa gtcttcagaa cagtttccaa cttttatgag 38700

gcagcatgaa cctgatacaa agcatactga cataaaagaa attacaagac aaacctcatt 38760

aacacagaca cagaaatatt ttttcaaata gcattttgaa tctagcaaaa tgaataggtt 38820

aataagctaa tctataacat tcccaagtat ggtctattcc aggactacat gttgtcttac 38880

cacttgaaaa ccaaggaatg tagtaattct ccacgttaag agaccaagga attattttta 38940

aagaccctga catagacaga aaaggcacta gataaaatcc attatccatt catgattttt 39000

aaaactcttc ccatatatat atatatatat atatccttat gattgattat ggatgattta 39060

tgttattgta cagcagaaac caacacaacg ttataacgca attatcctcc aataaagatt 39120

tttttaagtt acaaggtatt ttttaaaaaa catcttcaca attgaggaat agatagtaga 39180

acagaattcc tttccttttt aaaagttatc tatgaaaaac ttataactat tattaactta 39240

atggcaaaat atggaacatt ttcccctaag atcaggaaga atgcaaagat gttcactttc 39300

atcatttcta tttattacta taaagaagaa aaagaaaggg taaaatttag aaatcaagac 39360

tttcttttat tggtcttgat aagattgtat acaatgaaaa cccaaaataa ctcataaacc 39420

atttaaataa ataattgaat ttataaatgt catggataaa agatcaatgt acaaaaggaa 39480

actgcaattc tatgtgctag cctccaaaat caaaaattaa attaaaatat ttacaaagga 39540

agacatacca caagcctaga aataaagtta ttcaagacct ctacaataga aactacaaaa 39600

aaaactgtta agaggaatta aagctgacct agataaatta acaattatat taggctcatc 39660

atagtgttgt aaaaacgtta attttattca tgttattcta taaagtcaat gcaattccaa 39720

gcagagtccc aaaagatttg tgaaaattgc taaggagatc ctaaaattaa tatagaatca 39780

agtgggaaat agagaaggca tgacaatctt gatgaataaa aaggttggaa ggctcttgct 39840

atcaagtatc taaaaatatt gcaaaattat gtaaagactg agaaatcatc ttcagcaatc 39900

aaaagagatg gtaacataat caaacctttc tgaaagattt cttgaactat ggctggctgg 39960

gaattcccag acttcatagt tccctcccac tgctaagatc agagtaagca tattgtgttg 40020

gctaatgtta ttattacatc tattactata ccctatctgc ccctgctgcc ttctcccttc 40080

accatataca tcatgaaatc aaccctgaat attcattgga aggaccatta ctgaaactga 40140

agttccaata ctttgaccac ctgatgcaga gggccaattc attggaaaac accctgatga 40200

tgggaaagat tgagagcagg agacgggggt gacagagaat gagatggttg gatggcatca 40260

ccaactcaat ggacatgagt ttgagcaaac tccaggagat agtgaaggac agggaaggct 40320

ggtgtgcttc agtccattgg gtcacaaaga ttctgacatg acttagcaac ggaataacaa 40380

gattcagtga gaagccaatc ctaaaccaac caaagaattg tatttctctg gccacaatga 40440

attggtaaca gttggcaagt aagccaatca gattgaactg taacaggtat attggaattg 40500

gtcagaatga tcatcactct cttctccctg acacatcaac ctggaaagaa agcagctagg 40560

atcttctgag ggccactgtg gagagaaaga gcccaccagg aagaatagtt agtgcagaaa 40620

gatgtacaat caaggaatgg agacagaatt catccagata acatcttttt agctccagga 40680

tccagccatc tctgcgatta gttataacca aggatttttc tgtaatcaaa ctatttaatt 40740

ctctttatag tttacaaaaa tgcaaagaat gaagacaagc cagagactgg gaaaaattat 40800

ctgcaataca gtttatatat agtatatacc tgcaatacag gtatatatag tatacataat 40860

ttacatatat ataatataca acagatgttt tatgtatatg tatgtaacta gatagagaca 40920

tacacataca tttaaaaagg ataagtaacc agaggaaggg cttcccaggt ggtatagtgc 40980

aaaagaatcc tcctgccaat gcaggagaca caggagacat gggttcaatc cctggctcag 41040

aagatcccct ggagaaggaa atggcaaccc acttcagtat tcttgcctgg gaaatcccat 41100

ggacagagga gcctggtgga ctacagtcca tgggatcata aagagttgga catgactgag 41160

tgactgatca tgcacaaaag tggcagtttt aagacatggc tcccaaattc ttttatagtc 41220

ctctcatgaa agtgaagttc atatttcctc ttttgaatca acttataatt ctaagtatga 41280

attgtagctg aaactattaa tacctgtttc taaaaacttt gttacccagc ctattgaaat 41340

gtcagtttca aaatggggcc aataaaaatt acaattttct ataacatttt tagatctcag 41400

ctatgtattc tcacatgctc ctacattcac tgccacaggt atagaactct tttcttatct 41460

ctgtggactc tacacaattt aatcttgatt tcacgcaacc agtttctcca gggactaggg 41520

gtggggaaaa cggggagata gtgatcaaag gatgcaaact gccagataaa agatgaataa 41580

attcttgaga tctaactata gtcagggctt acctgacttc cctggtagct cagacagcaa 41640

agaatccacc tacattgtag gagacctggg gtttatctct ggtcagtaag atcccctgga 41700

gaagggaaca gctaactcac tccagtattc ttgcctggag aattccatgg acagagggga 41760

ctagaggtta cagtccctgg cattgcaaag aactggacat gactgatcaa ctgagcacac 41820

acacacacac acacaaccat aggaaacctt tcaaacagaa aaggaaccaa aaatgggtga 41880

aatgcttcaa caggtatccc ccagaaagaa gacatccagg gagttgcctg gttgcctagt 41940

ggttaggtgc tgggaactgc cacgggagat cccacccatg acagggtcat gtggaagaga 42000

actgttaagc aaggcttcag aacttaaggg gctccctagg ctttctcgag catctacccc 42060

aaaaccagaa tctgtctgtt ttactgtttc atgactttca ccaactcctc tgacattaac 42120

agggggctaa ccctgaccac ctttctctgg aaaaaatcaa cttagggtta tagctaataa 42180

gtttcctgga catgagagga atatttcaaa tcaaactccc tctgttagca ttctagcttg 42240

cttggcaggt atatccagac tcttatagct acgcatgtga ttatgtacag cctcccaact 42300

gtgagaggca cagaaagcct aaaacataga gcctttaaaa gagttaaagt tattagagta 42360

atgctagtgc tgatgtagga tttcattttt gggccaatgc ttgttgctaa gttcccatat 42420

ctcttatcca ctgtgcacct gggaatgcat tagttaacat agtgagaatg caagaaaaac 42480

aagtgtagcc ttgaatttaa ccatatcgga cttttgagct aattggttct ttcttgtaac 42540

tcactgcacc tttgctctat gaaaaatgta actctgtttg gcattttctg aggctgacat 42600

agatttaaaa tataaagaaa aaacactttg agggaaaata agttttctgg ttgagcagcc 42660

tttatcaaaa gagggtcata aaatgttcac aggcctccaa ggccagaaga tactgtatac 42720

aacatctttt gtggaaaagg tatacagaaa aatcctggtt ttgataaggg caaaactgct 42780

ggaatgtttg ggctgactct gtatgacctt gcctctttca tttcccttta tgtaaaggca 42840

aggtataaaa gtaccttttg aaaaataaag cttttggggc ctcgcagaag cttggtcacc 42900

ccgtgttttt tcttctttta tctttctttc tctctctctc tctctccctc tccctctctt 42960

tttcaggctg atcccttgga gcatgggggc tccctgcgtt cacttatctg cccaggtttc 43020

taagacctga acgggaagac attctgcatc ttcactccct cgggagactg ggagggcacc 43080

tgtggcctct gtgaacaggg caaacttctt gtcttgaagt tttattggtt ctctatgtaa 43140

accaaggaat atcagcctct ttctctcctc tattttctta tctacaacat tctttcctta 43200

tctctctcta aatcaatcgc cgacgctgtt tctccttcgg gtttccctgg atcctgcggg 43260

gcctggaccc cagcagttag gattccaggc tttcactatc atggcccagg ttcaatctct 43320

ggtcagggaa ctaaaaacct gcaagtcaca cagccaaaaa acaaaacaaa aaaaaacaaa 43380

ccagatatcc aaataatcaa taagcatata aaagaagtat tcaccattgt tacatatcag 43440

gtaaatgcaa attaaaacca gaaacaagat aatagtacat tctgtgttga acagctaaaa 43500

ttagaaagtg ctaatcaggc atgtggaaca gttaggacct tcattcattg cttttaggat 43560

tgtaagtgga attgcttttg aaaaactgga atacctacct agacataaag tctatcctat 43620

gattcagtaa tttcattctt atattcaaag tatgtaacaa gagacataag ttcatagtct 43680

gccaaaacag caattaagag gcaaattaga cattgaaaaa agaagccaaa tatgtaactg 43740

tacatattgt atcttaacat ttacatgaag atcaaaaaca agcaaactta ataaattaca 43800

atcaaagcca aaattgtgga gcgacatatt ttaatttttt tttttttttt tttttttggc 43860

tgcactaagt cttagttgca gtatgcagga tctttagttg tggcatgtga gatctagctc 43920

cctgaccagg gatcaaaccc cagctccctg cactggcagg cagattatta gctactggac 43980

caccaggaaa gtccccagag gaattattga gaaagcagat aaatgaactt tctgaaatcc 44040

tggaaaagtt ctgtttgtca cagtatttag tgtaaaattt catcaagctg tacacttaag 44100

attagcacac tttggaccat gtagatgaca acaaccctga tccaaactgg agccaactct 44160

atgcagtcaa cagatgtgcc aaagggcctg taatatcagc aaaattacaa tgcaagaact 44220

tgccagaaaa atccaagaag ctttgtatgg ccatgatggg gaaatttacg gaggggtcta 44280

tggagtggct gcctctgaga taatgaaagt caagcacttt gtgttctgct ttgagccagt 44340

attgatcagt gagtccaata attaggcaaa aagctggaaa ctgaagcttg gcaggccccc 44400

atgcatctgt ctccctgtct cattgccccc aaactcagaa taatggtttc ttccctctgc 44460

cttccaattc tcacacaaac tcttacttta gacaactcaa acctggaact agataaagaa 44520

ctgactctgg gaagtgcagt cccagccacg tccaaagtac tacaacataa gacagcccaa 44580

ccaactttac ttgtagcttt cctgttgcaa ggtctctttt ataaaagttc aaaatactgg 44640

gtccaattcc cagtcataag caaggataaa gaacaaaata caaaaataac ataacagatg 44700

agactcttct atcaaggctt ttgcacttat tgatttccac tggattactt attagatagg 44760

gaaagctttt aatggtaaaa actaataatg tttttgtgtg aaaaaaaaaa aagagagaga 44820

gagagaggtg gggggcgggg aatagtgggt aggcaatttc cagtttccac catactagat 44880

caaaatgaaa ttaccattta ccaaagaaac tacaaatact tgaatgtcga taccacaatg 44940

actgcacact tagagaacaa agagaattaa ctggtagcta ataataataa taaaagatca 45000

ctcatgccta tatattaaaa aaatacttta aatgcctgat gggtccagaa aactctgtaa 45060

tagaaacaac atttacatct gaaccctaat aaaatcaccc cataataaaa cataagtggc 45120

tagagctgaa aggtattaga ggaaatttat caccttaaac attcatatca gaaaattaaa 45180

ccggaaatca atgatcaagc agtagcccac tttaaggatg aggcactaat ctttgctttg 45240

agtatgaatt ttcttagaac acaataaatg atggtcatgg aggtattatc acatgattta 45300

cataacagag tttctctcag ttataggttt ttccaaaaga tgggtgacaa tttcttacat 45360

tcatagggtg tcttcacagt gtgagatctc acatgctccc taagctttga aaaagcatta 45420

aagacattcc ctcattcctt actttatata ttttctctgg tgtgagtttt cacatgtctt 45480

cgaaagtaag caggacaaac aaaggctttc ccacattcct tacattcata gggcttctca 45540

ccagtgtggc ttcttacatg tcttcgaaag gatgaaggac aactgaaagc tttcccacat 45600

tccagacatt caaagggttt ctctccagtg tgcatccttg tatggacagt caggtatgaa 45660

gaatggcgaa aggctttccc acattcctta cattcatagg gtttctcccc agtgtgtgtt 45720

ctcatgtgga tcctaagggc tgaggggtaa atgaaggctt ttccacattt cttacattca 45780

tagggtttct ctccagtgtg agttcttata tgtaccgtca ggtgggatga gctgatgaag 45840

gctttcccac attccttaca ttcataaggc ttttctccac tgtgagttct taagtgttca 45900

gtgagggatg aggaacgact gaaggctttc ccacattcct tacattcata ctgcaccttt 45960

ccaatgtgat ctttcacgtg tgctcgaaag gacgaagggc aactgaaggc ttttccacat 46020

tctttacatt catacggttt ctctctactc tgatttttca catgtgtatt cagggaagtg 46080

ggaagataga aggctttccc acattctagg cactcatagg gtttttcccc tgtgtgtttt 46140

ctcatgtgga tgctcaagga ggatggacaa ttgtaggctt tcccacattc cttacattta 46200

tagggtttct cgcctgtatg tgttctaacg tgtacagtga gcttcgagga ctcactgaag 46260

gctttcccac actcttgaca ttcataaggc ttttctccag tatggattct tatatgtatg 46320

ataaggtgag aggaggaact gaaggccttc ccacactcct tacactcata tggcttatct 46380

ccactgtgaa ttcttttgtg tttggagagt gaggaggaac agctaaaggc tttcccacac 46440

tccttacatt cataaggctt atctccactg tgaattcttt tgtgttctgt gagggatgaa 46500

gaacagctaa aggttttccc acattccctg cattcgcaac ttgtctttcc tgcatgaatc 46560

ttcatatgtg cccgaaagaa ggaagaacaa ctgaaggctt tggtacattc cttacattca 46620

tagggtttct cttcagtggg agttttcata tgcttcttaa aacaagcaaa aaaatggaaa 46680

cctttcccac attcgttaca ctgatagggt ttgctaccag tgtgagacct aatgtgattc 46740

ttcagggata aatgatctat gaaggccttt ttacacacac ggcactcata ggctcttact 46800

ccggtagtac tcttgagtat attaaggtgt gaaatttggc tgaaggttag gccacactga 46860

ttttcttcat tatgttcgta gatgttctca accccatgaa ttctttcaaa aataaaaagc 46920

acattattag tggcaagtaa atttttacca ttttcagtgc ctatgtgtat ttttctggcc 46980

tgtccaatga taagatgaaa gtactcacat tgtgctctaa gatagacaat attatgactg 47040

agtttttgag ttatgagatt tttctgatgg ttgctcaatg atttatgtgt taaacatgga 47100

agggctcaag tctcacttgt gaaaaaaata tcttatgaaa agtctttagg aaattacaat 47160

ttttgactaa gtttagattt ttcttttttt taattctgtg atattttaag attctttcct 47220

gagacactac ttttctctta tatgaatggc acttacctca aacgtttctt gtggttttca 47280

ttctgataat caatatcatg gtattcccag attttatgta aaatggacag tgaggaatca 47340

ctccttttga atcctactac atcctgttca ttggatattt ttccataagt atcttgtgga 47400

gcaactgatt cattaatttt aagttgaatc tcgaaacctg aaacaaagta gcaaaggcac 47460

ccatgagcaa aggactttgg cagtacagct ggttcaggac tttggtaata agcacacggc 47520

cgaaatagtg aagtgattag gaataatccc atgaagatgg aaactgatgg tagcatagat 47580

aagatattac taggagacta aaacaaaaag aaatggaatg aaacacacat gaccaaatac 47640

tacattacga agacaaaatg tggtctttcc caagaacaag gaacaggtga gaggactgaa 47700

gaaaagtcaa aatagtaatc aaggacttcc ctggtggcac agcggataag aatccacttg 47760

ccaatgtagg ggacactggt tcaatccctg gtccaggaag attccacatg ccacagagca 47820

actaagccag tgtgcagtaa ctactaagcc cacaagctac aaatactaag cccaagcact 47880

gcaactagag ggcagtcctc actctctgca actagagaaa agcccatgca aagcaatgaa 47940

gatccagcac agtaaaaaat gaaatttttt taaataaata aaatagtaat ctaagatatc 48000

tgtggaagct cagcttcctc agacaaaaca aagcttcatt ttgatcttat gttatttttc 48060

ccaaatgtaa tatcccccaa ccacatcagg tattcttgct ttactgatgc tccccctgga 48120

cagacagtct tctctccact gtctctaggt cctcctcttg tttccactgt aagatcacat 48180

acggtttgtg tagtggatac cctgttcaca tagaaaggta tatcgtgagg gaaaacagtg 48240

agttaccaca tatatttcta tgaaacagag caaaaactgc tcttctaata ctctaaagca 48300

agtgataggg atagaatagg atagttatac aggataggat agttatgcag aagtcccagt 48360

agtggattag agataacgag ggaaacctag agaactttga gagaccagtg gaagttcagt 48420

tcagttcagt tcagttcagt cgctcagctg tgtccgactc tttgcaacct ttgaatcaca 48480

acacgccagg cctccctgtc catcaccaac tcctggagtt cactcaaact catgtccatc 48540

aagttggtga tgccatccag ccatctcatc ctctgtcatc cccttctcct cctgccccca 48600

atccctccca gcatcacagt cttttccaat gagtcaactc ttcacatgag gtggccaaaa 48660

tactggagct tcagctttag catcattctt tccaaagaaa tcccagggct gatctccttc 48720

ggaatggact ggttggatct ccttgcagtc caagggactc tcaagagtct tctccaacac 48780

cacagttcaa aagcatcaat tctttctttc actcagcttt ctttatagcc caactctcac 48840

gtccatacat gaccactgga aaaatcatag ccttgactag atggaccttt gttggcaaac 48900

taatatctct gcttttcaat atactatcta ggttggttat aatttccttc caaggagtaa 48960

gcatctttta atttcatggc tgcaatcacc atctgcagtg attttggagc caaaaaaaaa 49020

taaagtctga cactgtttcc actgtttccc catctatttc gcataaagtg atgggagcag 49080

atgccatgat cttcgttttc tgaatgttga gctttaagcc aaccttttca ctctcctctt 49140

tcactttcat caagaggctt tttagttcct cttcactttc tgccatacag gtggtatcat 49200

acaggtttga ccacacaggg tcagacattc ttgtgcctga tacaaaggag gaactagtga 49260

tgtaagcctg aaatcaactc aaagaaggca gtcctttccc cccacacaca ctttcctttg 49320

acaataaaat tatagcccac ttaatcctca gtgcagggct ccctcatcta tccacttaca 49380

tctcttgcaa gcatcttata ctaataaatc taccttttgc ctatcagttt gcttcttgct 49440

gttcctttcg cactgagata caaagactct gaccatcatt aagtccagaa accaggtatg 49500

tgatctcagt tggaagacca tgggttttgg ccaggctgaa gttgcagcct catgagttca 49560

agtcccaaac tggattttgg ccaagttcga atcctggcac atgagctcaa actctggcac 49620

acgggttcaa gtcccaatct gaagtgaact ttttcaccgg tgtgagttta actgcaacaa 49680

aatatctaat ttatctttta aggggatggg gcagtctgat gaatagaact gatctgatat 49740

tcacacatag acctcgatat tattagaagc tggtccagta ctcacaggca ggatatgttg 49800

ttctcctgtt gaagacaaat aatctccgaa taccaatctt aggcaaggtt actctaatac 49860

catgttaaaa tgaaacaaaa taaggctact tcatgattta gcctaggggc aaagtattac 49920

tagaatttcc cctgctttct gtcagcatcc aatctaaaat gaacacctgt gaactagggt 49980

gacagtggcc ctcaaagatt cctatctaaa tagaacaatg gaacagaata gagagtctag 50040

aaatagaccc acataaatat agtcaactta cctttgacaa aggttcaaag gcaatacaga 50100

aatacagcaa ttcagaaata cagtagagaa aaaaataagt ctttccaaca aatggtgcta 50160

aaacaactac tagacattaa ggtacatttt taaaaatatc ttgacataga cttgcaaaaa 50220

attaactcaa aattcacagg gaggcataca gggctttggg ataactgggg tccatcaata 50280

gagagtaaaa aattagctca aaatggatca caaatctaaa tgtaaaacgt aaaactatgg 50340

aattcctaag agacaacagg gaaaaaaagt agatgcccta agatctagtg atttgctaga 50400

tatgtgaaaa ataatcaagg aaaacttcac taaatggagt tgagaggcca gaagaggaag 50460

ttttcatcta attctttaca acattaatta cagggagaat tgtccatcag agaccccaac 50520

aagaatcaca aattataatc ctaacaggaa aagatgtaca tcacatctcc tatcagaaat 50580

cactactcca gcaactcagc catcatcacc atgaactctc acctttatcc agtggacttt 50640

catccaaaac aacctctctc aatttcctcc gttttctcta taaaattaca ttcttctcca 50700

ttgttccgtg gacttgccta tggcttttgt tatagctttc ttatctcaaa ttgcaattcc 50760

cttgctattc ccaagtaaac tatttttttg ttggtaaaat aactttttat ttttaaagcc 50820

aataagtaac ctgaaaagca caattcatga aagaaagaac tgataagttg gtcttcatta 50880

atattaaaaa tttttgctct gagtaaaaca ctgtcaagaa aatgaaaaga catgccacat 50940

acttggagaa aatatttgca aaagacatgt gtgataaaga actattatcc aaaatatata 51000

cagaagtctt aaaactcaac aataagaaaa taacttgatt ttttttaaat aggccaaagt 51060

aagaatatac aatggagaaa aagtctcttc agcaagtggt gttgggaaca ctagacagtt 51120

tcatgtgatc aaggaaacaa caacacaccc tcacatcata cacaaaacta tacttggcca 51180

gaagccagca cgggagatcc catccatgac aaggtcatgt gaaggagcct gacaagcaag 51240

gcttcaggac tggagggacc ccctggacct gctcgagcat ctaccccaaa accaaaatct 51300

tactatttat gcctttcacc aactcttttg acattaacag ggggttatcc ccgaccacct 51360

ttttctggaa aaagtcaact ttgggctcta gttgataaat ctcctgggca taaaaggagt 51420

atttcaattt aaaccccctg ttagcattct agcttacttg gcaggtttat ccagactctt 51480

gcaacaatgt tgagccaatg cttgctgcca aattcccaca tcccttatcc attgtgttcc 51540

tgggagtgca tacagttaag atggagaaaa aacaagtagt agccttagca ttagcaatat 51600

tagactttga gttaataagt tctttctttg ctgtaaccta ctgaatcttt gctccataaa 51660

aacgtaactc tgtactttaa gggtgacgcg ggctaaggaa tttaacaaaa aacatttcaa 51720

gggaaagtaa gtgttttagc tgaccaacct ttatcaaaaa ggggtcataa aatttcaaca 51780

ggcctctggg caagaagata atgtacaaaa aataagaccc ttgtttatga aatggtatgc 51840

aggaagaaac ctggtatcga taaaagttaa aactgatgga atgttgagct gactctgcat 51900

ttttcacttt gctcaatgta taactcaggg tataaaagtt ccctctgaaa acaaagtgac 51960

gggccttgct caccaaagct tggtctcccc gtgtcattct ttctctctct ttccctttcc 52020

ttttcaggtt gatcccctgg agcgcagggg ccctctgagt tcactttctt gcctgggctt 52080

ctaagaccca ctcgagaagg tgcccaaggt ggggcacctt cagctacttg agagggcgcc 52140

tgtggcttat gtgaacagag caagtcccgt gctggggctt tattggcttt ctgcgtaaac 52200

caaggaatat caacctcttt ctctcctcta ttttcaggac tggaaaaggt cagttttcat 52260

gccaattcca aagaaaggca atgcaaaaga atgttcaaac tactgcacaa ttgcactcat 52320

ctcacatgct agtaaagtca tgctcaaaat tctccaagcc aggcttcagc agtacatgaa 52380

ctgtgaactc cctgacgttc aagctggttt tagaaaaggc agaggaacca gagatcaaat 52440

tgccaacatc cgctggatca tggaaaaagc aagagagttc cagaaacaca tctatttctg 52500

ctttattgac tatgccaaag cctttgactg tgtggatcac aataaactgt ggaaaattct 52560

gagacagatg ggaacaagac cacctgacca gcctcttgag aaatctgtat gcaggccagg 52620

aagcaacagt tcgaactgga catggaacaa cagactggtt ccaaatagga aaaggagtac 52680

gtcaaggctg tatattgtca ccctgcttat ttaacttcta tgcagagtac atcatgagaa 52740

acgctggact ggaagaagca caagctggaa tcaagattgc caggagaaat ttcaataacc 52800

tcagatatgc agatgacacc actcttatgg cagaaagtga agaggagcta aaaagcctct 52860

tgatgaaagt gaaacaggag agtgaaaaag ttggcttaaa gctcaacatt cagaaaacga 52920

agatcatggc atccggtccc atcactttat gggaaataga tggggaaaca gcggaaacag 52980

tgtcagactt tatttttggg ggctccaaaa tcactgcaaa tggtgactgc agccatgaaa 53040

ttaaaagacg cttactcttt ggaagaaaag ttatgaccat cctaggcagt atattcaaaa 53100

gcagagacat tactttgcca actaagctcc atctagtcaa ggctatggtt tttccagtgg 53160

tcatgtatgg atgtgagagt tggactgtga agaaggctga gcgccgaaga attgatgctt 53220

ttaaactgtg gtgttggaca agactcttga gagtcccttg gactgcaagg agatccaacc 53280

agtccattct gaaggagatc agccctggga tttctttgga aggaatgatg ctaaagctga 53340

agctccagta ctttggccac ctcatgcgaa gagttgactc attggaaaag actgtgatgc 53400

tgggagggat tgggggcaag agaagaaggg gacgaccgag gatgagatgg ctggatggca 53460

tcacggactc gatggacgtg agtctgagtg aactccggga gttggtgatg gacagggatg 53520

cctggcgtgc tgcgattcat ggggtcacaa agagtcagac atgactgagc gactgaactg 53580

aactgaactg aactgaatat aaacttgaga tttaccttaa taatgatgtg tcaatatagg 53640

ttcatcaact gtaatgaata tactactctg gcagaggcag tgcatttatg ggaaatcttt 53700

gtacttgcca gttaattttg ctgtgagcat acaaactgct ctaaaaaaaa aatagtgtac 53760

tggaaaaaaa aaatccatgt ccactgagaa ttcagaacat tactttattt ggaaatagat 53820

atttgcagaa gtaatcaagt taacatgaag ttatactcga tttgggtaag ccctaaatgc 53880

aatggctcat gtccttacaa ggacagaaag atgtagagac aaaggacaaa ggccctatga 53940

agatggaggc agagattaga gtgatatggc taccaaccaa ggactgccag caacaaccaa 54000

aagctaggaa gaggcaagga ggggttttct cctgagcctt cagaaggatc atgacacctt 54060

gatttcagac tttcaatctc ttgaaattta gaagagtaaa tttcacactt ccttggcagt 54120

acaggtggta cagaagacgc ctgccaaggc aggagacaca ggttcgatcc ctggtgcagg 54180

aagattccac atgccacgga gcaattaagc ccatgcacca caactactga agccctcgca 54240

ccctacaact accaaagccc tcgcacctaa agcatgggct ccccaacaac agaacccacc 54300

actgtgagaa gcccatgcac cccaacaaag agtagcccca ctcactgcaa ctagagaaag 54360

cccaagtgca gcaaagacct agcacagcct aaataaataa aatagttgtc tagctacaga 54420

ataaaactga ggagtagagg tagaggaagt ttttttttaa agtaaaagaa taagtttctg 54480

ttgttcctaa ctacccagtt tgtggcactt tgttatgaaa ggcctaggaa aatagaacag 54540

cctgttgtca tggacctacc cctaaatcat tcaacctaag tatataaatc ctataatatt 54600

tactttctaa cacactgcat tgttccccat gacatgtgtt tctccctcac tgccccaagg 54660

aataaaccca acttgttaaa ctggtggtct ttgggtacag ggaattaata gcagtaaaat 54720

tctcaaaagg tctcaaacca ccaattctct ccctgtcccc caaagtgacc cctgaagcct 54780

gtgcccacac catacacact taataagcct ccttgaggat tctgaccaca aaaaaaaagg 54840

aaaaacaggt tcaatatata tgtttatttt ctttcttttc ctcatgttaa tttcatattt 54900

atcttctcca ttactgaagc gttttgaata caatgacatc ttattgtcta tagtatatat 54960

tcaaaagggt ttgatacaaa ttcatcctca aaaaaaaaat gcttaaacaa tgaaagaatg 55020

actgaataaa gaaaaataat gctttcagta ccctgagaga aagtgaatac tttacaaccc 55080

tgagaaaatg aaaactctgc atttagtgcc agtggcaaaa tgggtaagga aactttcact 55140

aattcttttg cttgttttat attggtgaaa tactttaaca atacacatgt ttattttcat 55200

ggtgaagcca ctagattcca ctagctcctt ggggtcagtg accatgtctg tcttatttaa 55260

caatttattc cagtttctca acccaaatcc tagaacaagg gcaatttata agataaacct 55320

gttttctaaa taacataaca ttggaggaat gttaccatcc ttacctaatg aggccaggtt 55380

ccgaaagttt tccagcatca catctctgta gaggtttctc tgagtgagat tcagcagagc 55440

ccactcctct tgggtaaagt ccacagccac atcctcaaag accactgtgt cctaaaacat 55500

tccacatact ttgttcagaa aggtaccaac tcccccagca tgtgcaggag ggtgaatgag 55560

gctgacagta ctggggaact gagaatcaac tcacaggaag ttcaaaagat tcttttctcc 55620

caaatatcta ccctaggatt cagtcatcag atctttctca ttctatctaa gcatcctgac 55680

tgatcaaatt ctgtctcata gatttaacaa caatttttaa acactaaatt tatctttcca 55740

ctgtttgatg gtgaccagtt ccactcttac aataatcaaa aacatccaga acatattgca 55800

gaaacgagag aaatgctcta aaaatgaaat aatttccaca ttgaaagaag caaaaatccc 55860

ttgttagagg gacttccctg gaggttcagg gcttaagact gtgctttcca acgcagggga 55920

tgtgggttca atccttggtt gagggcctaa aatcccacat gccttggggc caaaaaacca 55980

aaacagaaaa cagaaaaaac aactgtaaca aaacattata ctgtaaaata gaaaaactat 56040

tgtaacgaaa aaaaactatt taaaaaaaat atccttgtta cagaaacaag ttcacctgct 56100

gccttattcc ccaccacagc aatcagcaca acacaaaaca ctaatataaa atttggatga 56160

ggtttaaatc cccaagagac aaggaccttt tctttttctt ttttccctcc atacacctgg 56220

agcccagaag tcagtgagaa gcacaatatt caacccaggc ccacagtcag tcatattttc 56280

ttacactcta ggcccaggag ctgtaaatta tagaacatga actaaaatca gcctatcacc 56340

tgtttatatt aattaaagtt ttactggaac acaataaaac atttatttat acactgtata 56400

tggctgcttt cacactaaaa tggcagaact gatgggaaat ccctgtcagt ccagtggtta 56460

ggactccacg ttttcactgc tgagggcaca ggttcaattc ctggtcaggg aaataagatc 56520

ccacaagctg cccaaaacaa acaaacaaaa aacaataaaa tgccagaact gagtaaaata 56580

gaaactaagg cctaaaatgc ttactatgtg acccaatgta ggaataggtt gttgatctct 56640

gctctaaatt taggatataa ataacctgat ggaatttaaa tattcttttg gagaattatt 56700

agctcttact tacctgtatc acatttctct gtaactcagc agctattctc tcttcctcca 56760

tgttaccttc atgaagaaag acagagtatt gagatgttac agctgagaca ggagaaagaa 56820

gacatgagaa tctgggtgtc cccacagtct ccacaatcaa gactgggttc agcagcacat 56880

ctgttatgag tgatcattct cctcaaaaca cacacacaca cacgcaaagc ccctgcatac 56940

ccaagcaaac acacactgat cttgtgagaa aatggagcaa gaaaaaaaaa ataataatag 57000

taacttactt acaaaacaga gactcacaga catagagaag gacattatgg ttgccagggg 57060

gaaggacagg ggaaagggat aattagggag tttagaatgg acatgtacac actcctatat 57120

ttaaagtgga taaccaacaa gggcctactg tgtagcacat ggaactctgt tcaatgttat 57180

gtggaggcct ggatgggagg agagtttagg gaagaatgga tacatgtata tgtatggctg 57240

agtgtcttag ttgctcacct gaaactatca caacactgtt aattagctac atcccaatcc 57300

aaaataaaaa gttttttttc tttaaagttg gagcaatttt atctcctcca gagctagaaa 57360

cagtcctctc actcttgtag atcattaagg aaaaaaaaag gtttaagagt ccattttgta 57420

agtgagtcag ccggagtcta aaaaatttgg ctgtcaatct gcccatgata atgaaaacat 57480

taaagatata agagcatgcc ttcagtagta agaatataca ttccatctca aaggaaagtg 57540

tgacttgtac accagatctc caggggttcc agacccaata tttatttctg cactgcctgg 57600

ccagccaaca tgcattacta ctcaatctct aactatgaga tcttcctcct ccgagggctg 57660

caaggtctcc aaaacctggt ttttgagaaa cagcacaact gactgaattt tacatgcagg 57720

tggcagagat gacatctcat gttaaatttt gcctgtacag gagatatagt cacagcataa 57780

caagaacacc tgaaatgaag ttggcatatg tgtcatctct gacagtagca tccacagcac 57840

tagtgcatga atttcaaata gtgaaaacac agcagtctct ctcacttcag tggaccatat 57900

atgtattgta gagccaatag aaacttcagt cacttagaca tgtgctcagt gttatccaat 57960

tagaaagcta agggagggtg tgtatttacc ttcaaagcta aatgcccaaa gagtgtgttt 58020

ctgaacatat accttataat atagttgtca gtgaggcccc tacgccctaa cattactggg 58080

gtctagccta gaatgctgtt gggcacacta tggagagtaa acaaataaag tattcccttc 58140

aactgtttta tctttgagct ccttctcttt ttttattaac ttatttttaa ttggagggaa 58200

gacttttcag agtcccttgg acaggaagga gatcaaacca gtcaatccta aaggaaatca 58260

accctgaata ctcattggaa ggattgaggc tgaaccttcg atactttggc catctgatgc 58320

aaagaaccaa ctcattggaa aagactctga ggctgagaaa gattcagagc aagaggagaa 58380

ggggatgaca gaagatggat gtcagctgga tggcatcatt gactcaatgg acatgagttt 58440

gagcaaactc tgggagacag tgagggtcag ggaagcctgg catgctgcag ttggacacaa 58500

cttagcaact gaatgcttcc ctggtagctc agctggtaac gatctgcctg caatgcaggg 58560

gagacctggg ttcgatccct gggatgggaa gatgcgctgg agaaggaaat ggctacccac 58620

tccagtattc tggcctggag gattccatgg actgtacagt ccatggggtc acaaagagct 58680

ggacacgact gagcgacttt cactttcact agtgactgaa caacaaatgc tttacaatgt 58740

tatgttggtt tattctatat atcaatgtga atcagctacg aattacatat attccctccc 58800

tcttgagtct ccctctcacc catgtccatc ccaccctcta ggttgtaaca cagcagcaag 58860

ctgagctccc tgtgctatac agcactttct actatccgtt gtacacatgg tagcatatat 58920

atgtcaatgc tactctcgca attcatccca ccgtctcctt cctccactgt atccacaagt 58980

ccattctcta catctgcatc tctattcctg cccttgagct ccttctcttg actaagccct 59040

atgtcttcaa caaggatgct ccccttaagg tccctacctc ctgctccttc atctcatatt 59100

tatttaggta atatttgccc tgtccaacta tgtgcagtca taggagacac agcactaaac 59160

aaaacagaaa aaccctaaag tacttgagtc ttataattgt tttaaggagg accagtaaat 59220

taccaaaata ttatcaggtg atggtatatg ctatataaaa atatatcacg ttatagagat 59280

aaggagatac acgcacattt atctttagca agtcagaacc acttatgtga cagggtagaa 59340

gcaggaaatt aaaacaactg ttttaggatt tccctggtgg tccagtggtt aagaatctgc 59400

aggggacagg ggtttgatcc ctagtccaga aagattttac atgccacagg gcaactaagc 59460

tgtgcaccac aactactgag ccagcactct agggccctca taccgcaact actaagctca 59520

cacgctgcaa ctactgaagt ccacacacct agagtgtgtg ctctgcaata agaagccaac 59580

gccatgagaa gcccacgcac tgcaaagaag agtagccccc actcgctaca actaaagaaa 59640

acccatgctt ggcaatggag acccagtgca gccaaaaata actttttaag aataaataaa 59700

tagaacaact gtttcaaata acacaaaaaa tcaatggctg gtgtggcaca tacatttatg 59760

cacaactgac cctcaaacaa ttgcaggggt tggggtacca agcctccagc aatggaaaat 59820

ctgagtttaa ctcatagtca gccctcagta tccaaggatt caatcaatgg cccatcctgt 59880

atttaatagt gaaaaaaaaa aatctgcata taagtggaca catgcatttc aaacctatgt 59940

tgttcaaggg ttaattgtat ttataaatat catcagttcc tatagaagaa atattagtaa 60000

ttataggtta accattgatg tataatggca gaaaaagaac cacataaagg tgtaaatata 60060

tatatatgac aaaattaatg atattttttg gagaaggaaa tggaaaccca ctccagtact 60120

cttgcctgga gaatcccatg gacagaggag cctggcaggc tacagtccac agggtcgcaa 60180

gagtcagaca ctacttagtg actaaaccac cacccatgat atttttaaaa acttagaaaa 60240

actaaaatgg caatactacc caaagcaacc tacagattta ttgccatccc tatcaaatta 60300

cccatgacat ttttcacaga actagaatac taaaattttt atgaaatcat aaaagaccca 60360

gaattgccaa agcaatcctg aggaaaaaga atgaagcaaa aggcataacc atcccaggct 60420

tcagactact acagaactac agtaatcaaa acagtgtggt atttgcacac acacacacac 60480

acacacaaaa aaaaaaaaaa aacaggcaca cagatcaatg gaacagaata gagagcccag 60540

aaacaaatcc atactcctgt ggtcaattaa tcgtcaacaa aggaggcaag aatatacaat 60600

gggtaaaaga taatctcttc agcaagtggg tgctgggaaa gctggacagc tgcatgtaaa 60660

tcaaagaaat tagaacacac tctctcccat gggaaaaagg gaatcctact acctgttggt 60720

aggaatgtaa actggtacaa ccattgtgga gaacagtatg taaggttcct taaaaaacta 60780

aacacagaac taccgtatga tgcaaaaatc ccactcccgg gcatatatct ggagaaaagc 60840

aattcaaaaa gatacacgca tccctatgtt caaagcagca ctattcacca cagcacaaca 60900

gtgaagtcag gtaaacaacc taaatatcca tcagtggagg aatgaataaa gatgtgatac 60960

atatataaaa tggaacacta ctcagccatt taaaaaaaga aaggaataat gctatttgca 61020

gcaaaacggg tacatccaga aattatcaca ctaagtgaag taagccagaa agtgaaagac 61080

aaataccata tgatatcact tatatatgga atctaaaatg tggtgcgaac aagccaatct 61140

acaaaatgga aaaagactca acggatatag agaacagatt tgtggttacc aaaggggaga 61200

ggagacagga cagggatgga ctaggagtat ggaattagta gatgcaaact atagaatgga 61260

taaacaacaa agtcctattg catagcaatg ggaattatat tcaatatcct gggatagact 61320

ataatgaaaa agaatatact acataaaaaa agactaaata ttacatgtga taaatataat 61380

tcacatcaat agaaaaagat catatgactt atccccttca atagaaaata gtgacttatg 61440

tctatcaata cccattgatg ataataattt aacccactag gactagaagg aaataggctt 61500

taattagaaa atatatatat tatctacaaa cacctatagc aaacatccta tttaataatg 61560

aaatgacaga attccctctg ggatcaggaa caaggcaagg atgcaattta tatgcttttc 61620

tacattgaac tgaaagtcct gggaaatgca ctaaataaac aaaaatgtaa gacacaagga 61680

ataaaaaaga aaacgctaaa actggcatat gatcacactt ccggtgtgaa aatttttaaa 61740

aatctatgga taattgatca acattcagag cagcaactgg caaacagggg ttaaaaagat 61800

actaagtaat cagttcacta gtatgtacct gaatataatg tagcaaacta actcccacaa 61860

tcaaagaaaa agaaaaaaca ggttaaaatc tatctcttgc acctagaaag gagatgcaga 61920

cggagttaag caaacgtcac cccgcactca ccgaacaaac cgaaatccac agacaggcgc 61980

agaaacgagg tggaggctca ggtcctcgtg acccgaatgg caaggatgct tgtcctttcc 62040

gaaaggagag cagaggatgc ttttggaggc cgattaagca cgagaatggc ccttcaactc 62100

ttgcctgcag ccgattcacc gcgactgctg gaccctcaca gagttcctga ttcagtgagt 62160

ttgggaccag ccgcggctgc tacagacccc gggaggggcg gggagcccaa gcggcagcct 62220

tttgaccaca gatcccaagg ccgagttccc cacctcccga gcaccagact ttgggccgcc 62280

tgggtcgaac tggatgggaa aatttctatc agatttagac agagatgcaa gaagacaagg 62340

ccgcccgctc gcgcacgcgc agaagcgtgc tgctgcttcc ggtttccgag ccacgtacag 62400

cgtaaggggc ggggtctcgg gagctgggaa atttgggatg gcggttgcag cttccgccat 62460

tgcaagcgga gaagtgctag tttcctccag ggaaagacgc gtcggggtct tggagccggg 62520

taagccgagg acttggcgtt ggatgacgct ggagcaggac caggcctgtg gcggggcttg 62580

gttgactagg cctgtggggc ggagctggga cgcgaccagg cctaggggcg tggcttagtt 62640

gaatattccc atgtgggatc ttagtttccc aatcagggat tgaacctctg ttgcctgcat 62700

tgcaagacag aaattaacca catgcttaac cactggacca ccagagaagt cccgaggtgg 62760

taggtttttg ctgagcccgt gtataacttt cctccctgcc accgtggcta ctttgttcag 62820

gagcccactg gggagacgag cagctggaaa aggaggctta ctggtatcca cagaaccagt 62880

tattctattg tcatagtcac tctgcagata cagaatggaa cccccacccc aaactttatt 62940

tgcatgtcaa gatattatgc cacacacata caccaagagg gtgtgaatat gtttaaaact 63000

tacattacaa atggcccttg ggtcagcaag gtaaaataac tctgcttgtg agttgccatc 63060

aaacatccag ttttttaaga cacttgagac atattctcca ccattaattt ctctcagtct 63120

tccatggacc tttcttgaag caataaaaag ttctcaatgg tgggatttac caaccatatg 63180

tttccacctt ctctcccact ccgtcttttt ctcccaacct tgcctgtctc tctgctgctg 63240

ctgctaagtc acttcagtcg tgtccgactc tgtgcgaccc cagagatggc agcccaccag 63300

gctcccccgt ccctgggatt ctccaagcaa gaacactgga ctgggttgcc atttccttct 63360

ccaatgcatg aaagtgaaaa gtgaaagaga agtcgctcag tcgtgtccga ctatttgtga 63420

ccccatggac tgcagcctac caggctcccc cgtccatggg attttccagg caagagtact 63480

ggagtggggt gccattgcct tctccggcct gtctctctgg gaccgttaat actcaacaca 63540

tctttctcag ttcttcatcc ccactaatct atttagatgg gaacttttga ctcaatgaag 63600

agccactatt aggttcacac ctgaaagatt ttttttccct tttttaatct ctcaggctct 63660

gatgtcctaa tatactaatt tatgttggct tcccttaaag accctccact catgtttctc 63720

cgactcacta attagttcag ttttctgatt tacttttctc aataactgac ttctcatcta 63780

cagatgtggg ggaaagaaag attatagacc catatgaatc agtataaacc ccacaatgcc 63840

tctgcaattg cacagttctg gcaacccact ccagaattct tgcctgggaa atcgcatggt 63900

cagaagggcc tggtgggcta tataccatgg gatcgcaaaa gagtcagacg tgacttatca 63960

actaaacaac aacaatctca aagaactaga ggcactatga tctattgttg gagatttcat 64020

agtcaagagc ttactcattc cttgtactaa tctctgaaac actcctatcc tcttaaaaaa 64080

atataagggg aattattttg tggggaaaaa aaagggttat aaattctatc atgtgcccac 64140

atttcctgtg gccccccaac ccaactgcca ttctggcttc ttttcttctg aaatcagcat 64200

actttacagt agtaggtctc tgttcagctt tctctagtat tcctctacat cctgactcca 64260

aatacctttt cactttagta tgacaaaaca atacacctgg aagtatgatg tcacaaggct 64320

tcactaacat cccctcctac ttcttccagt ttctcaacca taatctccaa gcctttcaac 64380

ctccctattc ttctactttg agtctaggtg gtggtgttgt tgtccagttg ctcagtcctg 64440

tccaacccca tgaactgcag catgccaggc ttccctgtcc ttcaccagct cccagagctt 64500

ggtcaaactc atgcccattg agttggtaat gccatccaac catctcatcc tctgctgaac 64560

ttttatattc acctgatcta acctcccctc aagagaaata tttttatctc tggaaaactt 64620

tgttatctaa agatatacag tttctgggaa ttccctggtg atccagtggt tagggataag 64680

tgctttcatt gcagggggcc tggattcaat ccctggtcat ggaactaaga tcttgcaagc 64740

ctcccagcca aaaataaaga aataagacac aaagtttctg aggataaatt ataattaaat 64800

cagatttagt aggttaattg tatagttcat gatgtaacac tgagaaacaa gtcctcacac 64860

caaactgagt aacagctatt aaaaattccc tttcctgggg acttccccag tggtccagtg 64920

gttaagaatc tcccttccaa tgcaggggat gctggctcat ccctggtgag ggaactaaga 64980

tcacacatgc tgcagggcag ctaagcctgt gcgccaatac taagatccaa tgcagcaaag 65040

taaatacatc aatataaagt aaaataaatt tttaaaaatt ccgtttcctt ttgctgaaag 65100

acaacttagt tcagttcagt tcagttcagt tcatttgctc agttgtgtcc aactctttgc 65160

gaccccatga attgcagcat gccaggccac cctgtccatc accgacaact cctgaagtcc 65220

acccaaaccc atgtccatcg agtcagtgat gccatccaac catctcatcc tctgtcgtcc 65280

ccttctcctc ctgacttcaa tctttcccag catcagggtc ttttacagtg agtcagctct 65340

ttgcatcagg tggccaaaat attggagttt cagcttcaac atcagtcctt ccaatgaaca 65400

cccaggactg atgtccttta ggatggactg gttggatctc cttgcagttc aaggggctct 65460

caagagtctt ctccaacacc acagtttaaa agcatcaatt cttcggcgct cagctttctt 65520

atagtctcac tgtcgcatcc atacatgacc acagaaaaag ccatagcctt gactagacag 65580

acttttgttg gcaaagtaat gtctctgctt tttaatatgc tgtctagatt ggtcataact 65640

ttccttccaa agagtaagcg tcttttaatt tcatggctgc agtcaccatc tgcactgatt 65700

ttggagccca aaaaaataaa gtcagccact gtttccccat ctatttcccc atgaagtgat 65760

gggaccggat gccatgatct tcgttttctg aatgttgagc tttaagccaa ctttttcact 65820

ctcccctttt actttcatca agaggctttt tagttcctca tcactttctg ccataagggt 65880

ggtgtcatct gcatatctga ggttattgat atttctccca gtaatcttga ttccagcttg 65940

tgtttcttcc agcccagagt ttctcatgat gtactctgca tataagttaa ataagcaggg 66000

tgacaatata catccttgat gtactccttt tcctatttgg aaccagtctg ttgttccatg 66060

tccagttcta actgttgctt cctgacctgc atacaggttt ctcaagaggt agatcacgtg 66120

gtctggtatc cccatctctt tcagaatttt ccacagttta ttgtgatcca catagtcaaa 66180

ggctttggca tagtcgataa agcagaaata gatgtttttc tggaactctc ttgctttttc 66240

catgatccag cggatgttgg caatttgatc tctggttcct ctgccttttc taaatccagc 66300

ttgaacatct ggaagttcac ggtacacgta tttaggattc ctaaagctta ttgtgaactg 66360

tgcactgtcg ccttaattat ctgcctccat gatatgacta ttcaattatg cacccaaatt 66420

tgaaagcaat tgtcatttat gtaagatgca tgaactactg aggaaagcaa acctccgagc 66480

caatcttggg ccacagcccc gccatgcggg tccggatcct gcgcctcagt gcctctcagc 66540

ggaaggaaaa gggtataact cccggatccg ggactttaga agcagtggcc tctagggccc 66600

gcccaacctc cgaggcccca gcccttaggc tgcacgcggg cactggaagt gcgcctgcgc 66660

gtttgtattt gcgcgtgggc aacgcggaag gtctgttatt tgtgtgcccc ggctccggtg 66720

tgaggtgaaa ttttcgtttc tctcgtctcg tctctgtgtg gtcaagcagg aggggaacag 66780

acccaagagg aggcttgaag tccaaggaca gtggcctcga gggctgacct ggccgccctg 66840

gcttcccgcc ggtgctgcgg ggcggcggcc cctcctccga gagctcggac ccactcggcc 66900

cgcaggagtc ccggcggcag tcccgggagg aggcgggccg ggccggccta ctctccatcc 66960

gcgtggctcc cgatttcaca agcctccaga gcagcctttg ggtccttcct ccgcagggaa 67020

aagaaatagc atctctgtcc ttctcgactc cccgggtccc ggtgggctct cggtggcttt 67080

actccggccg tggttgtcga tcattgaagt ttggtaagtc atattccgtt ggaaagagaa 67140

gaaacctttg taggttatta gggagcacgt gtgtttgatc ttaataagag taggagtgaa 67200

ggcattcata taaataataa atttaccata tgagagcccc gtaaagcccc aaaccttcaa 67260

aatatagaag cctctgggaa ggaagccaat cgaggctgtt ttccgttagt agctgccgtt 67320

ggaattgaat ttacgtaaga tgagttttga cgggtagatt tttattctag gtattcatat 67380

agaatttctc tttctttttt tttcgcccgt gctgcacggc tggagggatc ttagttcccc 67440

caccaggagg tgaaccctgg cccacgggat tgacagtgcg gagtcctaac cactggacca 67500

ccaagaaatt ccctcatctt gaaattttta tcttaagaaa atttgtggtc aataaaagga 67560

atatccatga atctaagttc actaatttaa gattttgtct gtcattttat atatatataa 67620

aatgatgaac catttaatgg taaattgcag acattgactt ctaagaatga ggacagtttc 67680

ctactaagaa caaaactccg ttgtacatcc aagaaaatca aaatttctcc agttttccaa 67740

aagtatattt tatagttgtc tggttttgga gggagctgga ttcaaataag gtttgcacct 67800

tgcatttagg ttttacatct gttttaccga aaacatttgc cagtattttt ggttcctgca 67860

gtccaggaga tttatatgga aaaatgttgg cattcccata tggtgatgtt ttcctttaat 67920

ttcatgtaat tgtgtatctc ataaagtgga cattgagtct agggtgtgtg tgctgtcgtg 67980

tctgtgtctt ttgcgtcctc atggactgta gcccaccagg ctcctctgtc cataggattt 68040

tccaggcaag actactggag tgggttgcca ttccctcctc caggggatcc tcttgaccca 68100

ggggtcaaac ccaggtcacc tgcctttgca ggcaggttct ttaccactga gtcacctggt 68160

acagccagta gtatctaata caaatgtaat gtgatttaaa aaattttagt agtcaaatta 68220

ggagaaaata tacatgtgaa gttattttta ataatatgtc atagctaacc caatttaccc 68280

agttattaat atataactgt tggtgaaatt aatgaccaat gtagcttata gaaagttatt 68340

agtgagaaat tttacatttc ttttgtacca agttgttgga ctctgatatg tattttacac 68400

ctaagctcac ctcagtatgg atgctaaatt tttattagaa attcctgatc tgtatttagc 68460

tttcagaaaa ttgactgttg aaaaaaaata tttggggaaa cccagattgc tccaaacata 68520

ctgaaagatt tttttagtaa ctgaacagtt ttatttctaa aatttaatta aaagtgagta 68580

aaatgacaaa ttcagcccct cagtctcact agccatattt cgtactcaca atagccgcat 68640

agagcaagac aatgactact gcgttagact gcaggtttaa agacttgaaa atttcccagg 68700

tgatgtgtac ttcatgttct atcacctcag gaggcacata aatgcaagtc gtccactgtg 68760

tattaggagt gcaacgcgtt tagttaaggt acccatctct gtctcgcaca gtcacatctt 68820

tcttggtggt aatctgtagg tgataagctt cccaggtggc tcggtggtaa agaatctgtc 68880

cacagtgcag gaatgctggt ttgatccctt tgtcaggaag atcccctgga gaagaaaatg 68940

acaacccact ccaggattct tgtctgggaa atcccatgaa cagaagagcc tgatgggcta 69000

atctgtgggg tcacaaaaga gttggacatg actcagcaac taaaccacaa caatctgagg 69060

gtgataactt ggcaacaggg gagtaatctg ttgcccagcc ctttcaccca gtggttttag 69120

catcacttgt tgctctttac ttctacctat ttttacactg gggtcttgaa aagtgcttgt 69180

tgttgttgtt gtttctaatt ctctttcttt ttttccaaat ttttccattc tcttgctgtc 69240

agtcttttgt aaacaagagc tttctctccc cacgtaccct gccttctcta tttgtttttt 69300

ccctttcacg gtttcacaac atattcccct gtttctcttt catttatcat attataaaca 69360

gatgctgtta tttgatgctc aggctctccc aaacttggtc aagagtagtc cttttaattt 69420

gattcatgtg tcctttcaac acatccctat aagtctttga gcgtcaattc ccaggtcact 69480

ttgaacttga ctgttgctgc ttagtcactt gagtcatatc caactctgtg tgaccctatg 69540

gactgtagcc tgccaggctc ctctgtccat ggaattctgc aggcaagagt actggagtgg 69600

gttgccatgc cctcctccag ggtatcttcc caacccaggg atcaaaccca ggtctcctgg 69660

ctgcattgca ggcagattct ttactgctga ggcaccagag aagccccaaa cttgactgtt 69720

aagagaccat aatcagtgat ttctccaaga agcctgtttc cttgtagaca ccaaggtctg 69780

tatgatacat ggattcagtg ttcctggggt ttaattgtgt ctaggccttt cagtggatat 69840

ctaaaatcga tattttcagg acttttctgg tggtccagtg cttaagacgc catgctgcca 69900

ctgcaggggg cacaagttcg atccctggtt ggggagctaa gatcctacat gccacacaaa 69960

gtggccaaaa atgtaaataa gtaagttttt taaaaaatat ttttaaaaaa cttacttatt 70020

tacattggat tcgtgtcaat gatggcaaaa ccaatacagt attgtaaagt aaaataaagt 70080

aaaaataaaa attgttttta aataaataaa taggcagtcc aagagaaaaa gaaagaagaa 70140

aagaaaaaaa atatttataa ctttatatcc tcctttccat ataaattata ttgtgaacgt 70200

actcttatat tattattctt caaaaaccca attaaaatat atcttttctt acatcatatg 70260

ttcatactca tattcctagt aaaaattttg ggcaacccag acctgctaag ttaatcgttt 70320

cctgcacact atttcgtgat cactgtccag tcatattgga gaattaacaa taatcttagg 70380

agttcaggct tttgagacag agtaacctcg aatcaggctc tggctcacca cttcctaagc 70440

ggtgatcttg gaccaattac tactgctgtt tgcgcatgaa ttgcctcaac tattgaatga 70500

cagtaagaat aacttgataa tcatatgagc tttcagtgtt tccagtacat aatgggtcct 70560

cagtaaatga caattattta tattcatgtc gtctacagtt tctaatgact ttcacataat 70620

atataatggc cgtcttctac agagcgatga ctaataaatg atgcttgatg acaaatcagt 70680

aatgcctact gcttaaagat tgatggcatg aggcaagact cccactacta cttaatcgga 70740

attgaactgt cttgaagaga cttcgggaat aacatgtata aggcagattt cactgtcaga 70800

ttcacagatg ccagcccttg attttttccc ttgtggcaag tacttgctga tgctcctttc 70860

agagacagtt ctttactggc ctgtgagcag aatgtctttg tggtctgggt ctacatagtc 70920

ctgcttctgg gctgtctagg agggtgctta agtatataac aatatcctgt tgtgtaaatc 70980

ctgggacttg gggagagaag ggtaagtctg cccatttttg tgagagaagt tctgcttaat 71040

tacatgatga attatcactg ttagccaaaa aaaaaataaa aaataaacaa ttttacctgt 71100

ctagacttta tctgtaaaat gaaattacat tattaaactt tttttccttt ttagcaaaat 71160

ccatttctaa tttcaggtga ggcagattgt agggcatttt atggcagcag tgtgtatgtg 71220

tttacttaga attagtgtgg ggtgtttcca ggcttgtgag tatggaaact gtgggcagcc 71280

tgaattctca ggttttgttt cttctcctta aggctttctc gggaattttt ctgtctttat 71340

gaagagaagt cagaagggga aaggactctg actggatgtc tgacaaatta ttttcaagtg 71400

agtaggaaat ttattctatt cttttagaaa agcacgtttc ttccttccag gtagatgtgt 71460

ttccttctag tgaaacagag ttttttattc caacagaacc tgcttaggga ctgagtccaa 71520

gttaaatttc ctcagatctt agggcctttc atttacataa gagaatgata ccatcatccc 71580

agtatttact aattcaatcc gatcatccat gctggttctg tgccctcatt ttgctataat 71640

agacagagag ctgacatgtg attctgagaa tttgtgctgt cactggagga gtgatgcatt 71700

tccagcattt attgtctata atgtgctcag aactattgct aatcctatca ctagagaaaa 71760

ttaagaccag aagaggtcac aatctagttg tggtgagata catcgttagg agagagagag 71820

gtactcttaa gctacacaat tggatgagat cactatgaat atgtccaggt agaggggaga 71880

aggggcttga ggactatcaa gccccagggt tgatggtggg agaacacgaa acctgtctag 71940

gctttgggtc tcccttcctc tttttcaagt gcacaactga tggagatggc aactgcctga 72000

tgccaggatg tttgtgatgg tgtaggatct cgtgaccttt gaggtcacag actttacagt 72060

acaatggctt cctcttgaaa aatgaagatc tgtccgttgt actgacttta ttttttctag 72120

gataaaaggc ttaggactta attgtgtata taagcttgag cttgggtttt aggcaaaaga 72180

tagggagtct attttgtgag agagagagag agagaatgtg aatatgtgtg cgttttagtt 72240

ttattttgaa gtttactggt ttgataaagt tgacatgaac attttgttgt ttctcaagtt 72300

atacctgaga gtatttggta tccctgaaga gcagactctc ggccccttat ttatggaagt 72360

atttgtcatc ccttacatgt tagtcttata tcaggcatct tcctctcaga gcagggcacc 72420

agttatgcag acctcgtctg atctttcagg tagaactaag aggaaagctg aagaaaatgg 72480

aaagttttcc aagagggggg aaaaggctaa ttatttattt atttggctgt gctgggtctt 72540

cattgctgtt cgcagctttc tctagttgtg acaagtgggg actgctcctt gttgtggcgc 72600

acaggcttct cattttggta gcctctcttg ttgtagagca caggctctag gctttcgggc 72660

tcagcagttg tggcacgtgg gctaagtttt tccacagcaa gtgggatctt ctcggaccag 72720

ggaccgaacc cacatcccct gcattggcag gtggattctt atctactgta ccaccaggga 72780

agtccaaact tttcttctct ttaacttttc cctcaccttt ggaaactttc tttcggcctg 72840

acagtagaat ctgtcccatt tttgaatttt aattttgtgt ttaagtcagt gtttgaaagt 72900

aaatacacat tggccttcat ttttaacacc ttccttccat ttattttcca ataacataat 72960

ttttggacat aacataatct gtaataacat aatctgtaat cttatttcag attgggagat 73020

ttgtctcaat accagaaggt cagcacctca gtggaatatt ttgaatggga aaaaatccaa 73080

cgtggtagac atg 73093

<210> 2

<211> 21

<212> DNA

<213> 人工序列(Artificial Sequence)

<400> 2

ggtcagcacc tcagtggaat a 21

<210> 3

<211> 21

<212> DNA

<213> 人工序列(Artificial Sequence)

<400> 3

ggtcagcacc tcagtggaat a 21

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