一种基于tale组装的线粒体dna编辑系统

当前位置：首页 > 最新专利 > 一种基于tale组装的线粒体dna编辑系统

一种基于tale组装的线粒体dna编辑系统

文档序号：3343 发布日期：2021-09-17 浏览：57次英文

一种基于TALE组装的线粒体DNA编辑系统

技术领域

本发明属于基因编辑

技术领域

，尤其是一种基于TALE组装的线粒体DNA编辑系统。

背景技术

转录激活样效应因子(TALE)是二代基因编辑工具的核心模块，其主要由若干34个氨基酸的重复单元构成，并利用12和13位的氨基酸构成的两个重复可变残基(RVD,repeat-variable di-residue)特异性识别DNA序列。已报道多种方法可用于TALE模块的组装，但这些方法大都繁琐、耗时、费力且代价高昂，因此如何高效组装定制TALE成为其推广和应用的难点。

线粒体疾病是以线粒体功能异常为显著特征的一类重大疾病。线粒体疾病常由细胞核基因突变和线粒体DNA突变引起，且线粒体DNA突变通常引起更严重的人类疾病，如线粒体脑肌病，共济失调等。采用ZFN和TALEN加上线粒体定位信号(MTS)，可以实现对突变的线粒体DNA进行切割，导致发生双链断裂的线粒体DNA被降解掉，但是该方法不能用于构建线粒体DNA突变动物模型，以及用于线粒体DNA突变修复，具有很大局限性。由于CRISPR/Cas9的sgRNA无法进入线粒体，导致该技术无法用于线粒体DNA编辑。目前，细菌毒素蛋白的DddA功能域即DddA_tox具有双链DNA脱氨基酶活性，通过和TALE相连形成胞嘧啶碱基编辑器(DdCBE)，可以实现线粒体中定点C/G到T/A的突变。因此，通过构建RVD文库及线粒体DNA编辑工具载体，形成了一种基于TALE组装的线粒体DNA编辑系统。

发明内容

本发明的目的是针对现有技术存在的问题，提供一种基于TALE组装的线粒体DNA编辑系统。

本发明另一个目的是提供采用该线粒体DNA编辑系统的编辑方法。

本发明再有一个目的是提供该编辑方法在制备模拟人类疾病的线粒体DNA突变动物模型中的应用。

本发明的目的通过下列技术方案实现的：

一种基于TALE组装的线粒体DNA编辑系统，包括RVD文库、线粒体定位骨架载体、细胞核定位骨架载体，RVD文库包含至少192个RVD模块，包括：160个双RVD模块、16个单RVD模块及16个半RVD模块。

所述的双RVD模块识别2个DNA碱基，从位置1到10，共有10个位置顺序，可依次对应识别DNA 5’端到3’端的第1-20位置的核苷酸，每个位置上有16种组合，因此共有160个双RVD模块；单RVD模块识别1个DNA碱基，从位置7-10，共有4个位置顺序，可依次对应识别DNA5’端到3’端的第13、15、17和19位置的核苷酸，每个位置上有4种可能，因此共有16个单RVD模块；半RVD模块识别1个DNA碱基，从位置8-11，共有4个位置顺序，可依次对应识别DNA5’端到3’端的第14、16、18、20和21位置的核苷酸，每个位置上有4种可能，因此共有16个半RVD模块。

进一步的，所述的不同位置RVD模块的DNA序列两端含有Bsa I酶切位点，用以产生4个不同碱基序列的粘性末端，以决定前后RVD模块连接的顺序。

进一步的，RVD文库中的每个载体上含有四环素抗性元件用于克隆筛选。

所述的线粒体DNA编辑系统，其中：RVD文库中不同位置的双、单和半RVD载体序列，其在Bsa I限制性内切酶切割后产生具有位置特异性的粘性末端序列，可使RVD序列按位置顺序自动排列组装，可以组装识别14-21个碱基TALE。

所述的线粒体DNA编辑系统，其中：160个双RVD的氨基酸序列如Seq ID NO：1-160所示；16个单RVD的氨基酸序列如Seq ID NO：161-176所示；16个半RVD的氨基酸序列如SeqID NO：177-192所示；160个双RVD的核苷酸序列如Seq ID NO：203-362所示；16个单RVD的核苷酸序列如Seq ID NO：363-378所示；16个半RVD的核苷酸序列如Seq ID NO：379-394所示。

注：下文中RVD文库DNA序列5’端和3’端连接的大写字母的碱基为Bsa I识别位点及间隔序列，非RVD模块DNA序列本身(本身为小写字母的碱基)。

所述的线粒体DNA编辑系统，其中：所述线粒体定位骨架载体的主要元件从5’端到3’端依次为线粒体定位信号(MTS)、ccdb毒素基因、half DddA_tox、尿嘧啶糖基化酶抑制基因(UGI)、氨卞青霉素抗性元件；4个线粒体定位骨架载体其核苷酸序列如Seq ID NO：193-196所示。

所述的线粒体DNA编辑系统，其中，所述细胞核定位骨架的主要元件从5’端到3’端依次为细胞核定位信号(NLS)、ccdb毒素基因、half DddAtox、尿嘧啶糖基化酶抑制基因(UGI)、氨卞青霉素抗性元件；4个细胞核定位骨架其核苷酸序列如Seq ID NO：197-200所示。

进一步的，在DddA_tox第1333氨基酸位置和第1397氨基酸位置分割产生的4种halfDddA_tox，分别给half DddA_tox融合线粒体定位信号(MTS)或核定位信号(NLS)，因此有4个线粒体定位骨架载体和4个细胞核定位骨架载体。

进一步的，每个载体上的Bsa I酶切位点间含有ccdb毒素基因，两端的Bsa I酶切产生不同的粘性末端，用于特异性连接1号位置的双RVD模块和8-11号位置的半RVD模块。

进一步的，每个载体上在half DddA_tox之后含有1个尿嘧啶糖基化酶抑制基因UGI，用于提高线粒体DNA定点的C/G到T/A的突变效率。

一种上述基于TALE组装的线粒体DNA编辑系统的编辑方法，包括以下步骤：

步骤1、根据所要编辑位点的DNA序列，设计TALE序列，选择权利要求1所述的RVD模块与骨架载体，通过Golden Gate克隆法一步完成载体组装，形成胞嘧啶碱基编辑器(DdCBE)；组装完成的DdCBE载体经过转化DH5α感受态、单克隆PCR验证、Sanger测序等步骤后，可获得正确组装的DdCBE载体；

步骤2、将正确组装的MTS-DdCBE转染所要编辑物种的细胞，或NLS-DdCBE与含有编辑位点的T载体共同转染HEK293FT细胞，通过Sanger测序或高通量测序检测DdCBE编辑效率，筛选对线粒体DNA或T载体编辑效果最好的DdCBE组合；

步骤3、将编辑效果最好的DdCBE进行体外转录，注射1细胞期受精卵，然后将胚胎移植到受体动物输卵管，或通过体外发育获得F0代动物；通过Sanger测序及高通量测序检测F0代的编辑效率，筛选高编辑效率的F0代动物；

步骤4、将高编辑效率的雌性F0代动物与野生型雄性动物交配，获得的F1代动物通过Sanger测序及高通量测序检测编辑效率，高编辑效率的动物则存在模拟人类疾病的可能。

所述的编辑方法在制备模拟人类疾病的线粒体DNA突变动物模型中的应用。

为了实现TALE的高效组装，相对于Kim Y等报道的含有424个载体的RVD文库(NatBiotechnol.2013Mar；31(3):251-8.)和Zhang等报道的含有256个载体的RVD文库(PLoSOne.2013Jun 20；8(6):e66459.)，本发明构建含有192个载体的RVD文库。相比于STAR方法需要几天时间(Methods Mol Biol.2018；1772:477-490.)，本发明只需要通过10轮的10分钟酶切加10分钟连接，共计4小时的反应就能完成组装。连接产物转化后经过12小时的菌落培养，进行PCR菌落鉴定并送测sanger测序，36小时之内就能得到经测序验证的正确载体。此外，相对于Mok BY等报道的TALE-DddA_tox(Nature.2020Jul；583(7817):631-637.)，本发明开发的一种基于TALE组装的线粒体DNA编辑系统，精简了骨架载体的数量，可以定制化快速构建线粒体DNA编辑载体，成功在动物上实现了线粒体DNA编辑。

本发明可以获得有益效果如下：

1)本发明精简了RVD模块文库，显著提高TALE组装效率。

2)本发明提出的TALE组装方法简化流程，操作简单，适合推广应用。

3)本发明提出的TALE组装方法在36小时之内可以获得经测序验证的正确载体。

4)本发明提出的TALE组装方法末位不受T碱基限制，可以是任意碱基。

5)本发明构建了线粒体定位骨架载体和细胞核定位骨架载体，对于有稳定细胞系的物种，直接将TALE连接到线粒体定位骨架载体，然后转染细胞系，筛选高效DdCBE对；对于没有稳定细胞系的物种，可以采用将TALE连接到细胞核定位骨架载体，然后和含有编辑位点的T载体共同转染HEK293FT细胞，筛选出高效的DdCBE对。高效的DdCBE对可用于制作线粒体DNA突变动物模型，以模拟人类疾病，并可潜在应用于人类线粒体DNA突变疾病的治疗。

附图说明

图1线粒体定位骨架载体

图1带有线粒体定位信号(MTS)的不同分割类型的DddA_tox，载体携带ccdb和UGI元件，ccdb位于两个Bsa I酶切位点之间，载体上带有氨卞青霉素抗性元件。

图2细胞核定位骨架载体。

图2带有细胞核定位信号(NLS)的不同分割类型的DddA_tox，载体携带ccdb和UGI元件，ccdb位于两个Bsa I酶切位点之间，载体上带有氨卞青霉素抗性元件

图3RVD文库示意图。

图3RVD文库载体示意图，左侧数字代表RVD的位置，双RVD模块位于1-10位，共160个载体；单RVD模块位于7-10位，共16个载体；半RVD模块位于8-11位，共16个载体。RVD两侧的DNA序列为Bsa I切割所产生的粘性末端DNA序列，每个RVD载体均带有四环素抗性。

图4人线粒体DNA G3733突变致病位点的保守性分析。

图4中箭头所指位置为编辑位点，灰色字母表示TALE识别位点，编辑位点的基因为nd1。G3733为人类线粒体DNA中的位置，G4247为斑马鱼线粒体DNA中的位置。

图5人线粒体DNA G8363突变致病位点的保守性分析。

图5中箭头所指位置为编辑位点，灰色字母表示TALE识别位点，编辑位点的基因为trnk。G8363为人类线粒体DNA中的位置，G8892为斑马鱼线粒体DNA中的位置。

图6DdCBE在T载体上编辑效果分析

图6左采用高通量测序分别分析T载体上G4247的编辑效率，图6右采用Sanger测序分析斑马鱼混合胚胎上G8892的编辑效率所用，DdCBE组合及方向如图X轴所示。

图7F0代斑马鱼线粒体DNA上G4247位点编辑效率分析。

图7左采用Sanger测序分析DdCBE在G4247位点的编辑效果，编辑位点采用箭头标出；图7右表示高通量测序分析DdCBE在F0代斑马鱼中G4247位点的编辑效率。

图8F0代斑马鱼线粒体DNA上G8892位点编辑效率分析。

图8左采用Sanger测序分析DdCBE在G8892位点的编辑效果，编辑位点采用箭头标出；图8右表示高通量测序分析DdCBE在F0代斑马鱼中G8892位点的编辑效率。

图9携带线粒体DNA突变的斑马鱼体型及运动轨迹分析。

图9左120日龄的线粒体DNA突变斑马鱼与野生型斑马鱼体型大小分析；图9右线粒体DNA突变斑马鱼与野生型斑马鱼运动轨迹分析。

图10携带线粒体DNA突变的斑马鱼运动能力分析。

图10左120日龄的线粒体DNA突变斑马鱼与野生型斑马鱼运动速度分析；图10右。120日龄的线粒体DNA突变斑马鱼与野生型斑马鱼运动距离分析。

图11携带线粒体DNA突变的斑马鱼线粒体结构分析。

采用透射电镜分析线粒体DNA突变斑马鱼与野生型斑马鱼肌肉组织中线粒体结构。

具体实施方式

以下通过实施例对本发明做详细说明，借此对如何应用本发明实现线粒体DNA的基因编辑充分理解并据以实施。

下面结合附图对本发明进一步说明。本发明提供一种基于高效组装TALE的线粒体DNA编辑系统。

其中，提供一种高效组装TALE的方法，该方法的使用需要一个含有192个载体的RVD文库，包括：160个双RVD模块、16个单RVD模块及16个半RVD模块。

其中，还提供一种匹配于RVD文库的线粒体DNA编辑系统，该系统包括：8个载体。

在本系统中，组装TALE的RVD文库及匹配于RVD文库的线粒体DNA编辑系统，通过在一个体系中的反应，可实现在36小时内完成组装。该系统高效且价格低廉，操作简单且易于推广，这是在本课题组长期研究和实践中所优化出来的重要创新。

实施例1

利用基于高效组装TALE的线粒体DNA编辑系统，实现斑马鱼线粒体DNA突变模型的构建，并模拟人类疾病模型。

(一)RVD模块的选择及TALE的组装

选择人类线粒体DNA(参考序列版本：NC_012920.1)上G3733和G8363的C/T to G/A的致病突变位点，根据保守性分析筛选相应的靶位点(图4和图5)。针对这2个致病突变位点，设计对应斑马鱼上G4247和G8892位点(参考序列版本:NC_002333.2)。根据DNA序列，在本发明RVD文库中选择相应位置的RVD，如：DNA序列的第1和第2个碱基为GT，选择RVD文库中1号位置识别GT序列的RVD模块；当第3和第4个碱基为AG时，则选择RVD文库中2号位置识别AG序列的RVD模块，并依次类推。当DNA序列长度为奇数时，选择识别最后一个碱基对应的半RVD模块。而当序列长度为偶数时，选择识别倒数第二个碱基对应的单RVD模块，并选择识别最后一个碱基对应的半RVD模块。

这里以G4247为例，如奇数个碱基序列G4247A-R15：AATAGAATAAGTCCT则挑选RVD模块为7个双RVD和1个半RVD；其RVD组合如下：AA1、TA2、GA3、AT4、AA5、GT6、CC7和hT8。如偶数个碱基序列G4247A-L16：GTAGCGCAAACAATTT则挑选RVD模块为7个双RVD和1个单RVD和1个半RVD；其RVD组合如下：GT1、AG2、CG3、CA4、AA5、CA6、AT7、pC8和hT9。

将线粒体定位的骨架载体或细胞核定位的骨架载体(图1和2)，与选择好的RVD模块，其中RVD模块数量与TALE识别的DNA序列长度相关，并按照表1的体系添加到PCR管中，试剂来源在表中给出。在PCR仪中使用下述反应条件进行反应：37℃ 10min,16℃ 10min，10个循环；50℃ 5min；80℃ 5min；4℃ hold。由于Bsa I内切酶和T4连接酶的存在，在一个反应体系内可同时实现载体的酶切和连接。

表1：TALE文库组装的反应体系

成分	体积(μL)
		RVD模块(50ng/μL)	0.5each
骨架载体(100ng/μL)	1
		T4 Buffer(NEB)	1
T4 DNAligase(NEB)	0.5
		Bsa I(NEB)	0.5
加H<sub>2</sub>O补充至	10

在反应结束后，将产物转化DH5α并采用含有氨卞青霉素的固体LB培养板进行筛选，之后挑取单克隆并使用下述引物进行PCR鉴定，引物序列如Seq ID NO:201-202所示。根据RVD数量，判断阳性的克隆，如16个RVD大小应为1759bp，15个RVD大小应为1657bp。之后，使用上述引物进行正反测序，序列正确的阳性克隆提取质粒用于后续实验。

(二)在体外细胞中进行DdCBE编辑效率的检测

针对没有可用细胞系的动物斑马鱼，可先将图4和5中所示的编辑位点的序列克隆到T载体上。待HEK293FT细胞密度达到70-90％时，提前2小时换液，细胞计数后，取10⁵个细胞用于细胞电转染(仪器：Lonza 4D-nucleofector)。如图4和5所示，将识别左右两端DNA序列的DdCBE各400ng及50ng含有编辑位点的T载体混合，之后使用SF-Cell Line 4D-nucleofector X-kit电转染HEK293FT细胞。对于有可用细胞系的动物，可直接采用上述相同方法，将识别左右两端DNA序列的DdCBE各400ng电转染细胞。

电转染完成后，将细胞接入12孔板中并培养24小时，接着使用含有2μg/mL的嘌呤霉素进行细胞筛选，培养48小时后将细胞消化离心，并收取细胞用于检测DNA突变效率。

收取的细胞样品DNA提取方式如下：采用30μL的QuickExtract^TM DNA ExtractionSolution(Lucigen)重选细胞，之后65℃加热45min，接着涡旋离心并使用98℃加热2min。

采用2×Green Taq Mix(Vazyme)扩增T载体或线粒体DNA上含有编辑位点的目的片段，之后用于Sanger测序；或采用Phanta Super-Fidelity DNA polymerase(Vazyme)及高通量测序建库引物进行高通量测序分析编辑效率。高通量测序的编辑效果如图6所示。

(三)使用DdCBE构建线粒体DNA突变斑马鱼模型

根据体内编辑的Sanger测序及高通量测序结果，筛选编辑效率最高的G4247和G8892位点的DdCBE组合。将识别左右两侧DNA序列的DdCBE载体各10μg混合，之后使用Pme I(NEB)限制性内切酶使载体线性化。采用DNA Clean&ConcentratorTM-5试剂盒(ZymoResearch)回收DNA，之后按照说明书使用mMESSAGE mMACHINE T7 Ultra Kit(Life,AM1345)进行体外转录，转录的mRNA使用RNA Clean&ConcentratorTM-5(Zymo Research)进行回收，并分装冻于-80℃保存。

为了获得线粒体DNA突变的斑马鱼，在斑马鱼的1细胞期进行注射，RNA的注射浓度为100ng/μL。收取获得的F0代斑马鱼组织，提取DNA并采用(二)中所述方法进行Sanger测序及高通量测序，如图7和8所示结果，F0代斑马鱼编辑效果存在高低，G4247位点突变斑马鱼线粒体DNA上的编辑效率为6.36-23.48％，而G8892位点突变斑马鱼线粒体DNA上的编辑效率为5.78-88.32％。

(四)携带线粒体DNA突变的斑马鱼模拟人类疾病模型

首先选择具有较高编辑效率的G4247和G8892位点突变雌性斑马鱼与野生型雄性斑马鱼交配，获得F1代斑马鱼。如表2所示，可获得高于或低于F0代编辑效率的F1代斑马鱼。

表2：F1代斑马鱼编辑效率分析

为了验证携带线粒体突变的斑马鱼能否模拟人类疾病。选取编辑效率较高的G4247A的F1代斑马鱼进行表型分析，如图9-11的结果表明F1代斑马鱼运动机能受损，肌肉组织中线粒体脊结构被破坏。因此，采用基于高效组装TALE的线粒体DNA编辑系统编辑产生的线粒体DNA突变斑马鱼动物模型，可模拟人类线粒体DNA突变引起的线粒体疾病。

上述说明示出并描述了发明的实施例，总之，本发明提供了一种基于TALE组装的线粒体DNA编辑系统，包括一种快速组装TALE模块的方法和一种匹配于TALE组装的线粒体DNA编辑系统。实验证实，本发明的一种基于TALE组装的线粒体DNA编辑系统，使TALE模块的组装高效且价格低廉，操作简单且易于推广；同时，利用匹配与TALE模块高速组装方法的线粒体DNA编辑系统，能够成功实现线粒体DNA编辑。除斑马鱼外，本发明亦已成功用于构建小鼠、大鼠、猴等线粒体DNA突变动物模型，表明该方法具有很好的稳定性和可重复性。

(一)RVD文库氨基酸序列

1)AA1

PEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPD

2)AA2

QVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

3)AA3

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

4)AA4

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVV

5)AA5

AIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVA

6)AA6

IASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAI

7)AA7

ASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

8)AA8

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

9)AA9

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

10)AA10

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIAS

11)AC1

PEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPA

12)AC2

QVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

13)AC3

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

14)AC4

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVV

15)AC5

AIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVA

16)AC6

IASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAI

17)AC7

ASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

18)AC8

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

19)AC9

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

20)AC10

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIAS

21)AG1

PEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPE

22)AG2

QVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

23)AG3

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

24)AG4

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVV

25)AG5

AIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVA

26)AG6

IASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAI

27)AG7

ASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

28)AG8

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

29)AG9

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

30)AG10

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

31)AT1

PEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPE

32)AT2

QVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

33)AT3

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

34)AT4

VAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVV

35)AT5

AIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVA

36)AT6

IASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAI

37)AT7

ASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

38)AT8

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

39)AT9

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

40)AT10

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

41)CA1

PEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPD

42)CA2

QVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

43)CA3

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

44)CA4

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVV

45)CA5

AIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVA

46)CA6

IASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAI

47)CA7

ASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

48)CA8

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

49)CA9

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

50)CA10

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIAS

51)CC1

PEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPA

52)CC2

QVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

53)CC3

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

54)CC4

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVV

55)CC5

AIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVA

56)CC6

IASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAI

57)CC7

ASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

58)CC8

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

59)CC9

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

60)CC10

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIAS

61)CG1

PEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPE

62)CG2

QVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

63)CG3

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

64)CG4

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVV

65)CG5

AIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVA

66)CG6

IASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAI

67)CG7

ASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

68)CG8

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

69)CG9

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

70)CG10

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

71)CT1

PEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPE

72)CT2

QVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

73)CT3

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

74)CT4

VAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVV

75)CT5

AIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVA

76)CT6

IASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAI

77)CT7

ASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

78)CT8

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

79)CT9

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

80)CT10

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

81)GA1

PEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPD

82)GA2

QVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

83)GA3

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

84)GA4

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVV

85)GA5

AIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVA

86)GA6

IASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAI

87)GA7

ASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

88)GA8

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

89)GA9

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

90)GA10

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIAS

91)GC1

PEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPA

92)GC2

QVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

93)GC3

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

94)GC4

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVV

95)GC5

AIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVA

96)GC6

IASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAI

97)GC7

ASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

98)GC8

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

99)GC9

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

100)GC10

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIAS

101)GG1

PEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPE

102)GG2

QVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

103)GG3

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

104)GG4

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVV

105)GG5

AIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVA

106)GG6

IASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAI

107)GG7

ASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

108)GG8

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

109)GG9

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

110)GG10

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

111)GT1

PEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPE

112)GT2

QVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

113)GT3

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

114)GT4

VAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVV

115)GT5

AIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVA

116)GT6

IASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAI

117)GT7

ASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

118)GT8

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

119)GT9

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

120)GT10

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

121)TA1

PEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPD

122)TA2

QVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

123)TA3

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQV

124)TA4

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVV

125)TA5

AIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVA

126)TA6

IASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAI

127)TA7

ASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

128)TA8

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

129)TA9

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

130)TA10

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIAS

131)TC1

PEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPA

132)TC2

QVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

133)TC3

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQV

134)TC4

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVV

135)TC5

AIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVA

136)TC6

IASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAI

137)TC7

ASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

138)TC8

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

139)TC9

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

140)TC10

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIAS

141)TG1

PEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPE

142)TG2

QVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

143)TG3

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQV

144)TG4

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVV

145)TG5

AIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVA

146)TG6

IASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAI

147)TG7

ASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

148)TG8

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

149)TG9

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

150)TG10

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

151)TT1

PEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPE

152)TT2

QVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

153)TT3

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQV

154)TT4

VAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVV

155)TT5

AIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVA

156)TT6

IASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAI

157)TT7

ASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

158)TT8

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

159)TT9

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

160)TT10

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

161)pA7

ASNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

162)pA8

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

163)pA9

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIA

164)pA10

SNIGGKQALETVQRLLPVLCQAHGLTPDQVVAIAS

165)pC7

ASHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

166)pC8

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

167)pC9

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIA

168)pC10

SHDGGKQALETVQRLLPVLCQAHGLTPAQVVAIAS

169)pG7

ASNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

170)pG8

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

171)pG9

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

172)pG10

SNNGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

173)pT7

ASNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

174)pT8

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

175)pT9

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIA

176)pT10

SNGGGKQALETVQRLLPVLCQAHGLTPEQVVAIAS

177)hA8

SNIGGRPALESIVAQLSRPDPALAA

178)hA9

SNIGGRPALESIVAQLSRPDPALAA

179)hA10

SNIGGRPALESIVAQLSRPDPALAA

180)hA11

GLGQILAAGRRWRALLPSYLALIRRWP

181)hC8

SHDGGRPALESIVAQLSRPDPALAA

182)hC9

SHDGGRPALESIVAQLSRPDPALAA

183)hC10

SHDGGRPALESIVAQLSRPDPALAA

184)hC11

GLGHMTAAGRRWRALLPSYLALIRRWP

185)hG8

SNNGGRPALESIVAQLSRPDPALAA

186)hG9

SNNGGRPALESIVAQLSRPDPALAA

187)hG10

SNNGGRPALESIVAQLSRPDPALAA

188)hG11

GLGQTMAAGRRWRALLPSYLALIRRWP

189)hT8

SNGGGRPALESIVAQLSRPDPALAA

190)hT9

SNGGGRPALESIVAQLSRPDPALAA

191)hT10

SNGGGRPALESIVAQLSRPDPALAA

192)hT11

GLGQMGAAGRRWRALLPSYLALIRRWP

(二)RVD文库DNA序列

1)AA1

GGTCTCGccccggagcaggtggtggccatcgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaggTGAGACC

2)AA2

GGTCTCGcaggttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagtggtTGAGACC

3)AA3

GGTCTCGtggtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagTGAGACC

4)AA4

GGTCTCGgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcaaTGAGACC

5)AA5

GGTCTCGgcaattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattTGAGACC

6)AA6

GGTCTCGgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgatagccTGAGACC

7)AA7

GGTCTCGagccagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcaagtTGAGACC

8)AA8

GGTCTCGaagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcttccTGAGACC

9)AA9

GGTCTCGttccaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcctctTGAGACC

10)AA10

GGTCTCGctctaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcgtcaTGAGACC

11)AC1

GGTCTCGccccggagcaggtggtggccatcgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaggTGAGACC

12)AC2

GGTCTCGcaggttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagtggtTGAGACC

13)AC3

GGTCTCGtggtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagTGAGACC

14)AC4

GGTCTCGgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcaaTGAGACC

15)AC5

GGTCTCGgcaattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattTGAGACC

16)AC6

GGTCTCGgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgatagccTGAGACC

17)AC7

GGTCTCGagccagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcaagtTGAGACC

18)AC8

GGTCTCGaagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcttccTGAGACC

19)AC9

GGTCTCGttccaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcctctTGAGACC

20)AC10

GGTCTCGctctaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcgtcaTGAGACC

21)AG1

GGTCTCGccccggagcaggtggtggccatcgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaggTGAGACC

22)AG2

GGTCTCGcaggttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagtggtTGAGACC

23)AG3

GGTCTCGtggtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagTGAGACC

24)AG4

GGTCTCGgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcaaTGAGACC

25)AG5

GGTCTCGgcaattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattTGAGACC

26)AG6

GGTCTCGgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgatagccTGAGACC

27)AG7

GGTCTCGagccagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcaagtTGAGACC

28)AG8

GGTCTCGaagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcttccTGAGACC

29)AG9

GGTCTCGttccaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcctctTGAGACC

30)AG10

GGTCTCGctctaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcgtcaTGAGACC

31)AT1

GGTCTCGccccggagcaggtggtggccatcgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaggTGAGACC

32)AT2

GGTCTCGcaggttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagtggtTGAGACC

33)AT3

GGTCTCGtggtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagTGAGACC

34)AT4

GGTCTCGgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcaaTGAGACC

35)AT5

GGTCTCGgcaattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattTGAGACC

36)AT6

GGTCTCGgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgatagccTGAGACC

37)AT7

GGTCTCGagccagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcaagtTGAGACC

38)AT8

GGTCTCGaagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcttccTGAGACC

39)AT9

GGTCTCGttccaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcctctTGAGACC

40)AT10

GGTCTCGctctaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcgtcaTGAGACC

41)CA1

GGTCTCGccccggagcaggtggtggccatcgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaggTGAGACC

42)CA2

GGTCTCGcaggttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagtggtTGAGACC

43)CA3

GGTCTCGtggtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagTGAGACC

44)CA4

GGTCTCGgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcaaTGAGACC

45)CA5

GGTCTCGgcaattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattTGAGACC

46)CA6

GGTCTCGgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgatagccTGAGACC

47)CA7

GGTCTCGagccagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcaagtTGAGACC

48)CA8

GGTCTCGaagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcttccTGAGACC

49)CA9

GGTCTCGttcccatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcctctTGAGACC

50)CA10

GGTCTCGctctcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcgtcaTGAGACC

51)CC1

GGTCTCGccccggagcaggtggtggccatcgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaggTGAGACC

52)CC2

GGTCTCGcaggttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagtggtTGAGACC

53)CC3

GGTCTCGtggtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagTGAGACC

54)CC4

GGTCTCGgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcaaTGAGACC

55)CC5

GGTCTCGgcaattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattTGAGACC

56)CC6

GGTCTCGgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgatagccTGAGACC

57)CC7

GGTCTCGagccagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcaagtTGAGACC

58)CC8

GGTCTCGaagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcttccTGAGACC

59)CC9

GGTCTCGttcccatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcctctTGAGACC

60)CC10

GGTCTCGctctcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcgtcaTGAGACC

61)CG1

GGTCTCGccccggagcaggtggtggccatcgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaggTGAGACC

62)CG2

GGTCTCGcaggttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagtggtTGAGACC

63)CG3

GGTCTCGtggtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagTGAGACC

64)CG4

GGTCTCGgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcaaTGAGACC

65)CG5

GGTCTCGgcaattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattTGAGACC

66)CG6

GGTCTCGgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgatagccTGAGACC

67)CG7

GGTCTCGagccagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcaagtTGAGACC

68)CG8

GGTCTCGaagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcttccTGAGACC

69)CG9

GGTCTCGttcccatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcctctTGAGACC

70)CG10

GGTCTCGctctcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcgtcaTGAGACC

71)CT1

GGTCTCGccccggagcaggtggtggccatcgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaggTGAGACC

72)CT2

GGTCTCGcaggttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagtggtTGAGACC

73)CT3

GGTCTCGtggtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagTGAGACC

74)CT4

GGTCTCGgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcaaTGAGACC

75)CT5

GGTCTCGgcaattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattTGAGACC

76)CT6

GGTCTCGgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgatagccTGAGACC

77)CT7

GGTCTCGagccagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcaagtTGAGACC

78)CT8

GGTCTCGaagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcttccTGAGACC

79)CT9

GGTCTCGttcccatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcctctTGAGACC

80)CT10

GGTCTCGctctcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcgtcaTGAGACC

81)GA1

GGTCTCGccccggagcaggtggtggccatcgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaggTGAGACC

82)GA2

GGTCTCGcaggttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagtggtTGAGACC

83)GA3

GGTCTCGtggtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagTGAGACC

84)GA4

GGTCTCGgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcaaTGAGACC

85)GA5

GGTCTCGgcaattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattTGAGACC

86)GA6

GGTCTCGgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgatagccTGAGACC

87)GA7

GGTCTCGagccagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcaagtTGAGACC

88)GA8

GGTCTCGaagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcttccTGAGACC

89)GA9

GGTCTCGttccaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcctctTGAGACC

90)GA10

GGTCTCGctctaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcgtcaTGAGACC

91)GC1

GGTCTCGccccggagcaggtggtggccatcgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaggTGAGACC

92)GC2

GGTCTCGcaggttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagtggtTGAGACC

93)GC3

GGTCTCGtggtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagTGAGACC

94)GC4

GGTCTCGgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcaaTGAGACC

95)GC5

GGTCTCGgcaattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattTGAGACC

96)GC6

GGTCTCGgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgatagccTGAGACC

97)GC7

GGTCTCGagccagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcaagtTGAGACC

98)GC8

GGTCTCGaagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcttccTGAGACC

99)GC9

GGTCTCGttccaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcctctTGAGACC

100)GC10

GGTCTCGctctaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcgtcaTGAGACC

101)GG1

GGTCTCGccccggagcaggtggtggccatcgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaggTGAGACC

102)GG2

GGTCTCGcaggttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagtggtTGAGACC

103)GG3

GGTCTCGtggtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagTGAGACC

104)GG4

GGTCTCGgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcaaTGAGACC

105)GG5

GGTCTCGgcaattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattTGAGACC

106)GG6

GGTCTCGgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgatagccTGAGACC

107)GG7

GGTCTCGagccagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcaagtTGAGACC

108)GG8

GGTCTCGaagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcttccTGAGACC

109)GG9

GGTCTCGttccaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcctctTGAGACC

110)GG10

GGTCTCGctctaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcgtcaTGAGACC

111)GT1

GGTCTCGccccggagcaggtggtggccatcgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaggTGAGACC

112)GT2

GGTCTCGcaggttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagtggtTGAGACC

113)GT3

GGTCTCGtggtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagTGAGACC

114)GT4

GGTCTCGgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcaaTGAGACC

115)GT5

GGTCTCGgcaattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattTGAGACC

116)GT6

GGTCTCGgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgatagccTGAGACC

117)GT7

GGTCTCGagccagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcaagtTGAGACC

118)GT8

GGTCTCGaagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcttccTGAGACC

119)GT9

GGTCTCGttccaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcctctTGAGACC

120)GT10

GGTCTCGctctaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcgtcaTGAGACC

121)TA1

GGTCTCGccccggagcaggtggtggccatcgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaggTGAGACC

122)TA2

GGTCTCGcaggttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagtggtTGAGACC

123)TA3

GGTCTCGtggtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagTGAGACC

124)TA4

GGTCTCGgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcaaTGAGACC

125)TA5

GGTCTCGgcaattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattTGAGACC

126)TA6

GGTCTCGgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgatagccTGAGACC

127)TA7

GGTCTCGagccagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcaagtTGAGACC

128)TA8

GGTCTCGaagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcttccTGAGACC

129)TA9

GGTCTCGttccaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcctctTGAGACC

130)TA10

GGTCTCGctctaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcgtcaTGAGACC

131)TC1

GGTCTCGccccggagcaggtggtggccatcgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaggTGAGACC

132)TC2

GGTCTCGcaggttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagtggtTGAGACC

133)TC3

GGTCTCGtggtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagTGAGACC

134)TC4

GGTCTCGgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcaaTGAGACC

135)TC5

GGTCTCGgcaattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattTGAGACC

136)TC6

GGTCTCGgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgatagccTGAGACC

137)TC7

GGTCTCGagccagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcaagtTGAGACC

138)TC8

GGTCTCGaagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcttccTGAGACC

139)TC9

GGTCTCGttccaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcctctTGAGACC

140)TC10

GGTCTCGctctaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcgtcaTGAGACC

141)TG1

GGTCTCGccccggagcaggtggtggccatcgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaggTGAGACC

142)TG2

GGTCTCGcaggttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagtggtTGAGACC

143)TG3

GGTCTCGtggtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagTGAGACC

144)TG4

GGTCTCGgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcaaTGAGACC

145)TG5

GGTCTCGgcaattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattTGAGACC

146)TG6

GGTCTCGgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgatagccTGAGACC

147)TG7

GGTCTCGagccagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcaagtTGAGACC

148)TG8

GGTCTCGaagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcttccTGAGACC

149)TG9

GGTCTCGttccaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcctctTGAGACC

150)TG10

GGTCTCGctctaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcgtcaTGAGACC

151)TT1

GGTCTCGccccggagcaggtggtggccatcgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaggTGAGACC

152)TT2

GGTCTCGcaggttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagtggtTGAGACC

153)TT3

GGTCTCGtggtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagTGAGACC

154)TT4

GGTCTCGgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcaaTGAGACC

155)TT5

GGTCTCGgcaattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattTGAGACC

156)TT6

GGTCTCGgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgatagccTGAGACC

157)TT7

GGTCTCGagccagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcaagtTGAGACC

158)TT8

GGTCTCGaagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcttccTGAGACC

159)TT9

GGTCTCGttccaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcctctTGAGACC

160)TT10

GGTCTCGctctaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgctagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcgtcaTGAGACC

161)pA7

GGTCTCGagccagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcaagtTGAGACC

162)pA8

GGTCTCGaagtaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcttccTGAGACC

163)pA9

GGTCTCGttccaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcctctTGAGACC

164)pA10

GGTCTCGctctaatattggtggcaaacaggctcttgagacggttcagcgcctccttccagttctctgtcaagcccacggactcaccccagatcaagttgtagcgattgcgtcaTGAGACC

165)pC7

GGTCTCGagccagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcaagtTGAGACC

166)pC8

GGTCTCGaagtcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcttccTGAGACC

167)pC9

GGTCTCGttcccatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcctctTGAGACC

168)pC10

GGTCTCGctctcatgacggtggcaaacaggctcttgaaaccgtccaacgccttctaccagttctctgtcaagcccacggactaaccccagcgcaagttgtagcgattgcgtcaTGAGACC

169)pG7

GGTCTCGagccagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcaagtTGAGACC

170)pG8

GGTCTCGaagtaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcttccTGAGACC

171)pG9

GGTCTCGttccaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcctctTGAGACC

172)pG10

GGTCTCGctctaacaatggtggcaaacaggctcttgaaaccgtacagcgcctactgccagttctctgtcaagcccacggtctgactccggagcaagttgtagcgattgcgtcaTGAGACC

173)pT7

GGTCTCGagccagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcaagtTGAGACC

174)pT8

GGTCTCGaagtaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcttccTGAGACC

175)pT9

GGTCTCGttccaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcctctTGAGACC

176)pT10

GGTCTCGctctaatgggggtggcaaacaggctcttgagactgttcagcgccttctaccagttctctgtcaagcccacggcctgacgcccgagcaagttgtagcgattgcgtcaTGAGACC

177)hA8

GGTCTCGaagtaatattggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

178)hA9

GGTCTCGttccaatattggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

179)hA10

GGTCTCGctctaatattggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

180)hA11

GGTCTCGgtcaaatattggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

181)hC8

GGTCTCGaagtcatgacggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

182)hC9

GGTCTCGttcccatgacggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

183)hC10

GGTCTCGctctcatgacggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

184)hC11

GGTCTCGgtcacatgacggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

185)hG8

GGTCTCGaagtaacaatggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

186)hG9

GGTCTCGttccaacaatggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

187)hG10

GGTCTCGctctaacaatggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

188)hG11

GGTCTCGgtcaaacaatggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

189)hT8

GGTCTCGaagtaatgggggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

190)hT9

GGTCTCGttccaatgggggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

191)hT10

GGTCTCGctctaatgggggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

192)hT11

GGTCTCGgtcaaatgggggcggcaggccggcgctggagagcattgttgcccagttatctcgccctgatccggcgttggccgcgTGAGACC

(三)定位骨架DNA序列

1)MTS-G1333N

atgttggggtttgtgggtcgggtggccgctgctccggcctccggggccttgcggagactcaccccttcagcgtcgctgcccccagctcagctcttactgcgggccgctccgacggcggtccatcctgtcagggactatgcggcgcaaacatctgagagcggcggaggcgggagccccggcgcggccgctgactacaaggatgacgacgataaaggtagcgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacagtggtccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccggctcctacgccctgggcccatatcagatctctgccccacagctgccagcatacaacggacagaccgtgggcacattctactatgtgaatgacgccggcggcctggagtctaaggtgtttagctccggcggctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

2)MTS-G1333C

atgttggggtttgtgggtcgggtggccgctgctccggcctccggggccttgcggagactcaccccttcagcgtcgctgcccccagctcagctcttactgcgggccgctccgacggcggtccatcctgtcagggactatgcggcgcaaacatctgagagcggcggaggcgggagccccggcgcggccgctgactacaaggatgacgacgataaaggtagcgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacagtggtccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccccaaccccctaccctaactatgccaatgcaggacacgtggagggacagagcgccctgttcatgcgggataacggcatctccgagggcctggtgttccacaacaatcccgagggcacctgcggcttttgcgtgaacatgaccgagacactgctgcccgagaatgccaagatgacagtggtgccacctgagggagcaatccctgtgaagagaggcgccaccggcgagacaaaggtgtttaccggcaactctaatagccctaagtccccaacaaagggcggctgctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

3)MTS-G1397N

atgttggggtttgtgggtcgggtggccgctgctccggcctccggggccttgcggagactcaccccttcagcgtcgctgcccccagctcagctcttactgcgggccgctccgacggcggtccatcctgtcagggactatgcggcgcaaacatctgagagcggcggaggcgggagccccggcgcggccgctgactacaaggatgacgacgataaaggtagcgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacagtggtccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccggctcctacgccctgggcccatatcagatctctgccccacagctgccagcatacaacggacagaccgtgggcacattctactatgtgaatgacgccggcggcctggagtctaaggtgtttagctccggcggcccaaccccctaccctaactatgccaatgcaggacacgtggagggacagagcgccctgttcatgcgggataacggcatctccgagggcctggtgttccacaacaatcccgagggcacctgcggcttttgcgtgaacatgaccgagacactgctgcccgagaatgccaagatgacagtggtgccacctgagggatctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

4）MTS-1397C

atgttggggtttgtgggtcgggtggccgctgctccggcctccggggccttgcggagactcaccccttcagcgtcgctgcccccagctcagctcttactgcgggccgctccgacggcggtccatcctgtcagggactatgcggcgcaaacatctgagagcggcggaggcgggagccccggcgcggccgctgactacaaggatgacgacgataaaggtagcgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacagtggtccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccgcaatccctgtgaagagaggcgccaccggcgagacaaaggtgtttaccggcaactctaatagccctaagtccccaacaaagggcggctgctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

5）NLS-G1333N

ccaaagaagaagcgtaaggtagactacaaagaccatgacggtgattataaagatcatgacatcgattacaaggatgacgatgacaagggtaccgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacggggcgccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccggctcctacgccctgggcccatatcagatctctgccccacagctgccagcatacaacggacagaccgtgggcacattctactatgtgaatgacgccggcggcctggagtctaaggtgtttagctccggcggctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

6）NLS-G1333C

ccaaagaagaagcgtaaggtagactacaaagaccatgacggtgattataaagatcatgacatcgattacaaggatgacgatgacaagggtaccgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacggggcgccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccccaaccccctaccctaactatgccaatgcaggacacgtggagggacagagcgccctgttcatgcgggataacggcatctccgagggcctggtgttccacaacaatcccgagggcacctgcggcttttgcgtgaacatgaccgagacactgctgcccgagaatgccaagatgacagtggtgccacctgagggagcaatccctgtgaagagaggcgccaccggcgagacaaaggtgtttaccggcaactctaatagccctaagtccccaacaaagggcggctgctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

7）NLS-G1397N

ccaaagaagaagcgtaaggtagactacaaagaccatgacggtgattataaagatcatgacatcgattacaaggatgacgatgacaagggtaccgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacggggcgccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccggctcctacgccctgggcccatatcagatctctgccccacagctgccagcatacaacggacagaccgtgggcacattctactatgtgaatgacgccggcggcctggagtctaaggtgtttagctccggcggcccaaccccctaccctaactatgccaatgcaggacacgtggagggacagagcgccctgttcatgcgggataacggcatctccgagggcctggtgttccacaacaatcccgagggcacctgcggcttttgcgtgaacatgaccgagacactgctgcccgagaatgccaagatgacagtggtgccacctgagggatctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

8）NLS-1397C

ccaaagaagaagcgtaaggtagactacaaagaccatgacggtgattataaagatcatgacatcgattacaaggatgacgatgacaagggtaccgtggatctacgcacgctcggctacagccagcagcaacaggagaagatcaaaccgaaggttcgttcgacagtggcgcagcaccacgaggcactggtcggccatgggtttacacacgcgcacatcgttgcgctcagccaacacccggcagcgttagggaccgtcgctgtcaagtatcaggacatgatcgcagcgttgccagaggcgacacacgaagcgatcgttggcgtcggcaaacggggcgccggcgcacgcgctctggaggccttgctcacggtggcgggagagttgagaggtccaccgttacagttggacacaggccaacttctcaagattgcaaaacgtggcggcgtgaccgcagtggaggcagtgcatgcatggcgcaatgcactgacgggtgcccccctgaacctgaccccagagaccggcttactaaaagccagataacagtatgcgtatttgcgcgctgatttttgcggtataagaatatatactgatatgtatacccgaagtatgtcaaaaagaggtatgctatgaagcagcgtattacagtgacagttgacagcgacagctatcagttgctcaaggcatatatgatgtcaatatctccggtctggtaagcacaaccatgcagaatgaagcccgtcgtctgcgtgccgaacgctggaaagcggaaaatcaggaagggatggctgaggtcgcccggtttattgaaatgaacggctcttttgctgacgagaacaggggctggtgaaatgcagtttaaggtttacacctataaaagagagagccgttatcgtctgtttgtggatgtacagagtgatattattgacacgcccgggcgacggatggtgatccccctggccagtgcacgtctgctgtcagataaagtctcccgtgaactttacccggtggtgcatatcggggatgaaagctggcgcatgatgaccaccgatatggccagtgtgccggtgtccgttatcggggaagaagtggctgatctcagccaccgcgaaaatgacatcaaaaacgccattaacctgatgttctggggaatataaatgtcaggctcccttatacacagccagggtctctcgcgttgaccaacgaccacctcgtcgccttggcctgcctcggcggacgtcctgcgctggatgcagtgaaaaagggattgggaggctccgcaatccctgtgaagagaggcgccaccggcgagacaaaggtgtttaccggcaactctaatagccctaagtccccaacaaagggcggctgctctggaggcagcaccaacctgtctgacatcatcgagaaggagacaggcaagcagctggtcatccaggagagcatcctgatgctgcccgaagaagtcgaagaagtgatcggaaacaagcctgagagcgatatcctggtccataccgcctacgacgagagtaccgacgaaaatgtgatgctgctgacatccgacgccccagagtataagccctgggctctggtcatccaggattccaacggagagaacaaaatcaaaatgctg

（四）PCR扩增引物

1）上游引物

tgaccgcagtggaggcagtg

2）下游引物

Ttcactgcatccagcgcagg

序列表

<110> 南京医科大学

<120> 一种基于TALE组装的线粒体DNA编辑系统

<160> 394

<170> SIPOSequenceListing 1.0

<210> 1

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 1

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Asp

65 70

<210> 2

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 2

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Asp Gln Val

65 70

<210> 3

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 3

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val

<210> 4

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 4

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val Val

<210> 5

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 5

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Asp Gln Val Val Ala

<210> 6

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 6

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

50 55 60

Gln Val Val Ala Ile

<210> 7

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 7

Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

50 55 60

Val Val Ala Ile Ala

<210> 8

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 8

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 9

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 9

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 10

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 10

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 11

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 11

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Ala

65 70

<210> 12

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 12

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Ala Gln Val

65 70

<210> 13

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 13

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val

<210> 14

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 14

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val Val

<210> 15

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 15

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

20 25 30

Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Ala Gln Val Val Ala

<210> 16

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 16

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

20 25 30

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

50 55 60

Gln Val Val Ala Ile

<210> 17

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 17

Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val

20 25 30

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

50 55 60

Val Val Ala Ile Ala

<210> 18

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 18

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 19

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 19

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 20

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 20

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 21

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 21

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 22

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 22

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 23

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 23

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 24

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 24

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 25

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 25

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 26

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 26

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 27

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 27

Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 28

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 28

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 29

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 29

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 30

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 30

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 31

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 31

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 32

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 32

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 33

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 33

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 34

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 34

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 35

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 35

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 36

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 36

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 37

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 37

Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 38

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 38

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 39

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 39

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 40

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 40

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 41

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 41

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Asp

65 70

<210> 42

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 42

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Ala Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Asp Gln Val

65 70

<210> 43

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 43

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val

<210> 44

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 44

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val Val

<210> 45

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 45

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Asp Gln Val Val Ala

<210> 46

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 46

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

50 55 60

Gln Val Val Ala Ile

<210> 47

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 47

Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

50 55 60

Val Val Ala Ile Ala

<210> 48

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 48

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 49

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 49

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 50

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 50

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 51

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 51

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Ala

65 70

<210> 52

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 52

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Ala Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Ala Gln Val

65 70

<210> 53

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 53

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val

<210> 54

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 54

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val Val

<210> 55

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 55

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

20 25 30

Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Ala Gln Val Val Ala

<210> 56

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 56

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

20 25 30

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

50 55 60

Gln Val Val Ala Ile

<210> 57

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 57

Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val

20 25 30

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

50 55 60

Val Val Ala Ile Ala

<210> 58

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 58

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 59

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 59

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 60

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 60

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 61

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 61

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 62

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 62

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Ala Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 63

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 63

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 64

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 64

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 65

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 65

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 66

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 66

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 67

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 67

Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 68

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 68

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 69

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 69

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 70

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 70

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 71

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 71

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 72

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 72

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Ala Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 73

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 73

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 74

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 74

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 75

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 75

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 76

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 76

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 77

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 77

Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 78

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 78

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 79

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 79

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 80

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 80

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 81

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 81

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Asp

65 70

<210> 82

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 82

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Asp Gln Val

65 70

<210> 83

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 83

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val

<210> 84

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 84

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val Val

<210> 85

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 85

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Asp Gln Val Val Ala

<210> 86

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 86

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

50 55 60

Gln Val Val Ala Ile

<210> 87

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 87

Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

50 55 60

Val Val Ala Ile Ala

<210> 88

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 88

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 89

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 89

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 90

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 90

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 91

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 91

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Ala

65 70

<210> 92

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 92

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Ala Gln Val

65 70

<210> 93

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 93

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val

<210> 94

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 94

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val Val

<210> 95

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 95

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Ala Gln Val Val Ala

<210> 96

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 96

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

50 55 60

Gln Val Val Ala Ile

<210> 97

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 97

Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

50 55 60

Val Val Ala Ile Ala

<210> 98

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 98

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 99

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 99

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 100

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 100

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 101

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 101

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 102

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 102

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 103

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 103

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 104

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 104

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 105

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 105

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 106

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 106

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 107

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 107

Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 108

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 108

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 109

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 109

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 110

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 110

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 111

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 111

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 112

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 112

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 113

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 113

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 114

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 114

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 115

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 115

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 116

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 116

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 117

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 117

Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 118

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 118

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 119

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 119

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 120

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 120

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 121

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 121

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Asp

65 70

<210> 122

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 122

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Asp Gln Val

65 70

<210> 123

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 123

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val

<210> 124

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 124

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Asp Gln Val Val

<210> 125

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 125

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Asp Gln Val Val Ala

<210> 126

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 126

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp

50 55 60

Gln Val Val Ala Ile

<210> 127

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 127

Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln

50 55 60

Val Val Ala Ile Ala

<210> 128

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 128

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 129

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 129

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala

<210> 130

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 130

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 131

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 131

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Ala

65 70

<210> 132

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 132

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Ala Gln Val

65 70

<210> 133

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 133

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val

<210> 134

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 134

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Ala Gln Val Val

<210> 135

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 135

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Ala Gln Val Val Ala

<210> 136

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 136

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala

50 55 60

Gln Val Val Ala Ile

<210> 137

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 137

Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln

50 55 60

Val Val Ala Ile Ala

<210> 138

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 138

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 139

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 139

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala

<210> 140

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 140

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 141

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 141

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 142

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 142

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 143

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 143

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 144

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 144

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 145

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 145

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 146

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 146

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 147

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 147

Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 148

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 148

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 149

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 149

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 150

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 150

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 151

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 151

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

1 5 10 15

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

20 25 30

Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys

35 40 45

Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala

50 55 60

His Gly Leu Thr Pro Glu

65 70

<210> 152

<211> 70

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 152

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

1 5 10 15

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

20 25 30

Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala

35 40 45

Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly

50 55 60

Leu Thr Pro Glu Gln Val

65 70

<210> 153

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 153

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val

<210> 154

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 154

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

1 5 10 15

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

20 25 30

Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu

35 40 45

Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr

50 55 60

Pro Glu Gln Val Val

<210> 155

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 155

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

1 5 10 15

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

20 25 30

Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr

35 40 45

Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro

50 55 60

Glu Gln Val Val Ala

<210> 156

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 156

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

1 5 10 15

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

20 25 30

Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val

35 40 45

Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu

50 55 60

Gln Val Val Ala Ile

<210> 157

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 157

Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln

35 40 45

Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln

50 55 60

Val Val Ala Ile Ala

<210> 158

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 158

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 159

<211> 68

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 159

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala

<210> 160

<211> 69

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 160

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg

35 40 45

Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val

50 55 60

Val Ala Ile Ala Ser

<210> 161

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 161

Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val

20 25 30

Ala Ile Ala

<210> 162

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 162

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala

<210> 163

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 163

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala

<210> 164

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 164

Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Asp Gln Val Val Ala

20 25 30

Ile Ala Ser

<210> 165

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 165

Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val

20 25 30

Ala Ile Ala

<210> 166

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 166

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala

<210> 167

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 167

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala

<210> 168

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 168

Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Ala Gln Val Val Ala

20 25 30

Ile Ala Ser

<210> 169

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 169

Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala

<210> 170

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 170

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala

<210> 171

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 171

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala

<210> 172

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 172

Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser

<210> 173

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 173

Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu

1 5 10 15

Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val

20 25 30

Ala Ile Ala

<210> 174

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 174

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala

<210> 175

<211> 34

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 175

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala

<210> 176

<211> 35

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 176

Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu

1 5 10 15

Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala

20 25 30

Ile Ala Ser

<210> 177

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 177

Ser Asn Ile Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 178

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 178

Ser Asn Ile Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 179

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 179

Ser Asn Ile Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 180

<211> 27

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 180

Gly Leu Gly Gln Ile Leu Ala Ala Gly Arg Arg Trp Arg Ala Leu Leu

1 5 10 15

Pro Ser Tyr Leu Ala Leu Ile Arg Arg Trp Pro

20 25

<210> 181

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 181

Ser His Asp Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 182

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 182

Ser His Asp Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 183

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 183

Ser His Asp Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 184

<211> 27

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 184

Gly Leu Gly His Met Thr Ala Ala Gly Arg Arg Trp Arg Ala Leu Leu

1 5 10 15

Pro Ser Tyr Leu Ala Leu Ile Arg Arg Trp Pro

20 25

<210> 185

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 185

Ser Asn Asn Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 186

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 186

Ser Asn Asn Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 187

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 187

Ser Asn Asn Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 188

<211> 27

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 188

Gly Leu Gly Gln Thr Met Ala Ala Gly Arg Arg Trp Arg Ala Leu Leu

1 5 10 15

Pro Ser Tyr Leu Ala Leu Ile Arg Arg Trp Pro

20 25

<210> 189

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 189

Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 190

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 190

Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 191

<211> 25

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 191

Ser Asn Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu

1 5 10 15

Ser Arg Pro Asp Pro Ala Leu Ala Ala

20 25

<210> 192

<211> 27

<212> PRT

<213> 人工序列(Artificial Sequence)

<400> 192

Gly Leu Gly Gln Met Gly Ala Ala Gly Arg Arg Trp Arg Ala Leu Leu

1 5 10 15

Pro Ser Tyr Leu Ala Leu Ile Arg Arg Trp Pro

20 25

<210> 193

<211> 1792

<212> DNA

<213> 人工序列(Artificial Sequence)

<400> 193

atgttggggt ttgtgggtcg ggtggccgct gctccggcct ccggggcctt gcggagactc 60

accccttcag cgtcgctgcc cccagctcag ctcttactgc gggccgctcc gacggcggtc 120

catcctgtca gggactatgc ggcgcaaaca tctgagagcg gcggaggcgg gagccccggc 180

gcggccgctg actacaagga tgacgacgat aaaggtagcg tggatctacg cacgctcggc 240

tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac 300

cacgaggcac tggtcggcca tgggtttaca cacgcgcaca tcgttgcgct cagccaacac 360

ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag 420

gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag 480

gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa 540

cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc 600

aatgcactga cgggtgcccc cctgaacctg accccagaga ccggcttact aaaagccaga 660

taacagtatg cgtatttgcg cgctgatttt tgcggtataa gaatatatac tgatatgtat 720

acccgaagta tgtcaaaaag aggtatgcta tgaagcagcg tattacagtg acagttgaca 780

gcgacagcta tcagttgctc aaggcatata tgatgtcaat atctccggtc tggtaagcac 840

aaccatgcag aatgaagccc gtcgtctgcg tgccgaacgc tggaaagcgg aaaatcagga 900

agggatggct gaggtcgccc ggtttattga aatgaacggc tcttttgctg acgagaacag 960

gggctggtga aatgcagttt aaggtttaca cctataaaag agagagccgt tatcgtctgt 1020

ttgtggatgt acagagtgat attattgaca cgcccgggcg acggatggtg atccccctgg 1080

ccagtgcacg tctgctgtca gataaagtct cccgtgaact ttacccggtg gtgcatatcg 1140

gggatgaaag ctggcgcatg atgaccaccg atatggccag tgtgccggtg tccgttatcg 1200

gggaagaagt ggctgatctc agccaccgcg aaaatgacat caaaaacgcc attaacctga 1260

tgttctgggg aatataaatg tcaggctccc ttatacacag ccagggtctc tcgcgttgac 1320

caacgaccac ctcgtcgcct tggcctgcct cggcggacgt cctgcgctgg atgcagtgaa 1380

aaagggattg ggaggctccg gctcctacgc cctgggccca tatcagatct ctgccccaca 1440

gctgccagca tacaacggac agaccgtggg cacattctac tatgtgaatg acgccggcgg 1500

cctggagtct aaggtgttta gctccggcgg ctctggaggc agcaccaacc tgtctgacat 1560

catcgagaag gagacaggca agcagctggt catccaggag agcatcctga tgctgcccga 1620

agaagtcgaa gaagtgatcg gaaacaagcc tgagagcgat atcctggtcc ataccgccta 1680

cgacgagagt accgacgaaa atgtgatgct gctgacatcc gacgccccag agtataagcc 1740

ctgggctctg gtcatccagg attccaacgg agagaacaaa atcaaaatgc tg 1792

<210> 194

<211> 1942

<212> DNA

<213> 人工序列(Artificial Sequence)

<400> 194