1. The method for loading the medicine core rod into the tube is characterized by comprising the following steps:

s1, immersing the thin-wall silicone rubber tube into an organic solution, and swelling for 1-2min to obtain a swollen thin-wall silicone rubber tube;

s2, placing the drug core rod into a thin-wall silicone rubber tube, standing and volatilizing the organic solution for 2-10 hours, and plugging two ends of the thin-wall silicone rubber tube by using an adhesive to obtain a semi-finished product;

s3, indirectly heating the semi-finished product by steam for 5-10min under the rated working pressure of 0.7MPa and the steam temperature of 95-105 ℃, extruding the semi-finished product, and cooling the semi-finished product for 5-10min at-5-0 ℃ to obtain the silicon rubber rod.

2. The method for loading the core rod into the tube according to claim 1, wherein in the method for loading the core rod into the tube S2, the core rod is cooled at-5 to 0 ℃ for 5 to 10min before being loaded into the thin-walled silicone rubber tube.

3. The method for loading the drug core rod into the tube according to claim 1, wherein the drug core rod has a weight of 143mg to 158mg, a length of 40 ± 1mm, and a diameter of 1.9 to 2.1 mm; the length of the thin-wall silicone rubber tube is 50 +/-1 mm, the outer diameter is 2.3-2.4mm, and the single-layer wall thickness is 0.16-0.18 mm.

4. The method for loading the drug core rod into the tube according to claim 1, wherein the distance between the drug core rod and the end part of the thin-wall silicon rubber tube is 5mm plus or minus 1 mm.

5. The method for loading the core rod into the tube according to claim 1, wherein the pressure of the extrusion semi-finished product in the method for loading the core rod into the tube S3 is 0.5-1.5 bar.

6. The method for loading the drug core rod into the tube according to claim 1, wherein the length of the adhesive at the two ends of the thin-wall silicone rubber tube is 1.8-2.2 mm.

7. The method for filling the tube into the flux-cored bar according to claim 1, wherein the organic solvent is prepared by mixing n-hexane and tetrahydrofuran according to a volume ratio of 1 (2-3).

8. The method for loading the medicine core rod into the tube according to claim 1, wherein the feed-liquid ratio of the thin-wall silicone rubber tube to the organic solvent is 1 (1.2-3).

Background

Subcutaneous implant contraception is one of the most effective, reversible methods of birth control. The long-acting antifertility drug embedded with the vitex negundo enters a blood circulation system through local capillary vessels, so that the gastrointestinal absorption process of the traditional preparation is avoided, the bioavailability of the drug is improved, and the side effect of the drug is reduced. For antifertility drugs, unplanned conception caused by forgetting to take the medicine can also be avoided.

The long-acting contraceptive implant is a preparation made of a bar-shaped silicon rubber material with the size similar to a match stem, each group of preparation has various types of six types, two types and a single type, each silicon rubber rod consists of a silicon rubber medicine core rod containing contraceptive medicine and a thin-wall silicon rubber tube sheathed outside the medicine core rod, the silicon rubber medicine core rod is implanted under the skin of women of child-bearing age, and the medicine in the medicine core rod can be uniformly and slowly released into the blood of a human body through the externally-coated thin-wall silicon rubber tube, so that the contraceptive effect is achieved.

In order to ensure the slow and uniform release of the drug and achieve the long-acting and high-efficiency contraceptive effect, the inner wall of the thin-wall silicon rubber tube must be in close contact with the drug core rod wrapped in the tube, so that an assembly and matching method of the drug core rod and the thin-wall silicon rubber tube is urgently needed at present, so that the thin-wall silicon rubber tube is in close contact with the drug core rod.

Disclosure of Invention

In order to improve the close contact between the thin-wall silicon rubber tube and the drug core rod and prolong the contraception effect of the long-acting contraception implant, the application provides a drug core rod tube loading method.

A method for loading a tube by a medicine core rod comprises the following steps:

s1, immersing the thin-wall silicone rubber tube into an organic solution, and swelling for 1-2min to obtain a swollen thin-wall silicone rubber tube;

s2, placing the drug core rod into a thin-wall silicone rubber tube, standing and volatilizing the organic solution for 2-10 hours, and plugging two ends of the thin-wall silicone rubber tube by using an adhesive to obtain a semi-finished product;

s3, indirectly heating the semi-finished product by steam for 5-10min under the rated working pressure of 0.7MPa and the steam temperature of 95-105 ℃, extruding the semi-finished product, and cooling the semi-finished product for 5-10min at-5-0 ℃ to obtain the silicon rubber rod.

By adopting the technical scheme, at the temperature, the thin-wall silicone rubber tube swells in the organic solvent, so that the inner diameter of the thin-wall silicone rubber tube is increased, the medicine core rod is conveniently arranged in the thin-wall silicone rubber tube, and the semi-finished product is obtained after the two ends of the thin-wall silicone rubber tube are plugged by the adhesive. The semi-finished product is heated indirectly by steam, the thin-wall silicon rubber tube is heated and expanded to generate deformation, then the semi-finished product is extruded, so that the inner wall of the thin-wall silicon rubber tube is in close contact with the drug core rod, at the moment, the semi-finished product is cooled rapidly, the deformation of the thin-wall silicon rubber tube is preserved, the thin-wall silicon rubber tube in the silicon rubber rod is promoted to be in close contact with the drug core rod, and the contraception effect of the long-acting contraception implant is favorably prolonged.

Preferably, in the method S2, before the flux core rod is loaded into the thin-wall silicone rubber tube, the flux core rod is cooled at-5-0 deg.C for 5-10 min.

By adopting the technical scheme, the medicine core rod is arranged in the thin-wall silicon rubber tube, and the volume change of the medicine core rod after the semi-finished product is indirectly heated, extruded and cooled by steam is reduced due to the volume shrinkage of the cooled medicine core rod, so that the close contact between the rubber tube and the medicine core rod is promoted, and the contraception effect of the long-acting contraception implant is prolonged.

Preferably, the weight of the medicine core rod is 143mg-158mg, the length is 40 +/-1 mm, and the diameter is 1.9-2.1 mm; the length of the thin-wall silicone rubber tube is 50 +/-1 mm, the diameter of the thin-wall silicone rubber tube is 2.3-2.4mm, and the thickness of a single-layer wall of the thin-wall silicone rubber tube is 0.16-0.18 mm.

By adopting the technical scheme, under the above conditions, the drug core rod is arranged in the thin-wall silicon rubber tube, the drug activity is strong, the dosage is small, and the steam indirect heating and cooling process of the semi-finished product is combined, so that the drug in the drug core rod can be slowly released, and the contraceptive effect of the long-acting contraceptive implant is improved.

Preferably, the distance between the medicine core rod and the end part of the thin-wall silicone rubber tube is 3-5 mm.

By adopting the technical scheme, the drug in the drug core rod can be released slowly, and the contraceptive effect of the long-acting contraceptive implant is improved.

Preferably, in the method S2, the drug core rod is put into a thin-walled silicone rubber tube, and then put into a stainless steel net to volatilize the organic solvent.

By adopting the technical scheme, the semi-finished product is extruded within the pressure range, so that the inner wall of the thin-wall silicon rubber tube is further promoted to be in close contact with the drug core rod under the condition of not damaging the semi-finished product, and the contraceptive effect of the long-acting contraceptive implant is prolonged.

Preferably, the pressure of the extruded semi-finished product ranges from 0.5 to 1.5kgf/cm²。

By adopting the technical scheme, the semi-finished product is extruded within the pressure range, so that the inner wall of the thin-wall silicon rubber tube is further promoted to be in close contact with the drug core rod under the condition of not damaging the semi-finished product, and the contraceptive effect of the long-acting contraceptive implant is prolonged.

Preferably, the length of the adhesive at the two ends of the thin-wall silicone rubber tube is 1.8-2.2 mm.

By adopting the technical scheme, the adhesive plugs the two ends of the thin-wall silicone rubber tube, so that the active ingredients can be effectively prevented from being directly released from the two ends.

Preferably, the organic solvent is formed by mixing n-hexane and tetrahydrofuran according to a volume ratio of 1 (2-3).

By adopting the technical scheme, the organic solution prepared from normal hexane and tetrahydrofuran can effectively promote the swelling of the thin-wall silicone rubber tube, so that the drug core rod can be conveniently put into the thin-wall silicone rubber tube for subsequent steam heating and cooling treatment, thereby further promoting the close contact between the rubber tube and the drug core rod and improving the contraceptive effect of the long-acting contraceptive implant.

Preferably, the material-liquid ratio of the thin-wall silicone rubber tube to the organic solvent is 1 (1.2-3).

By adopting the technical scheme, the thin-wall silicone rubber tube is fully dissolved in the organic solvent, and the swelling of the thin-wall silicone rubber tube can be effectively promoted, so that the close contact between the rubber tube and the drug core rod is further promoted, and the contraception effect of the long-acting contraception implant is favorably prolonged.

In summary, the present application has the following beneficial effects:

1. according to the application, the drug core rod is arranged in the thin-wall silicon rubber tube swelled by the organic solvent, and after steam indirect heating, extrusion and cooling treatment, the thin-wall silicon rubber tube is heated and expanded, the thin-wall silicon rubber tube is extruded to be in close contact with the drug core rod, and cooling promotes the thin-wall silicon rubber tube in the silicon rubber rod to be in close contact with the drug core rod, so that the contraceptive effect of the long-acting contraceptive implant agent is prolonged;

2. the specifications of the drug core rod and the thin-wall silicon rubber tube are controlled, after the drug core rod is arranged in the thin-wall silicon rubber tube, the drug activity is strong, the dosage is small, and then the indirect steam heating and cooling process of a semi-finished product is combined, so that the drug in the drug core rod can be slowly released, and the contraceptive effect of the long-acting contraceptive implant can be effectively prolonged;

3. the organic solution prepared from n-hexane and tetrahydrofuran can effectively promote the swelling of the thin-wall silicone rubber tube, so that the drug core rod can be conveniently loaded into the thin-wall silicone rubber tube for subsequent steam heating and cooling treatment, thereby further promoting the close contact between the rubber tube and the drug core rod and improving the contraceptive effect of the long-acting contraceptive implant.

Drawings

FIG. 1 is a schematic view showing the overall structure of a stainless steel net according to an embodiment of the present application;

FIG. 2 is a schematic sectional view of the stainless steel net according to the embodiment of the present application.

Reference numerals: 1. a stainless steel mesh body; 2. an end cap; 3. a pressure head; 4. and a cylinder.

Detailed Description

The present application will be described in further detail with reference to the following drawings and examples.

The raw materials used in the examples of the present application are commercially available except for the following specific descriptions.

The CAS number of n-hexane is 110-54-3;

tetrahydrofuran CAS number 109-99-9;

the thin-wall silicone rubber tube is adopted from Shenzhen Qiyu silicone rubber Co., Ltd;

the adhesive is human fibrin adhesive, and is obtained from Hualan bioengineering GmbH; the electric heating steam generator is NBS-AH in model and is obtained from Wuhan Beeher Cisco technologies, Inc.;

the model of the medical freezer is YCD-265, which is collected from the medical technology Limited of Jintai medical science;

the NORGREN Nonguan cylinder has model number of RA/8250/M/400, and is obtained from swan electromechanical technology, Inc. in Shanghai.

Examples

Example 1

A method for loading a tube by a medicine core rod comprises the following steps:

s1, immersing the 1 thin-wall silicone rubber tube into 1.0mL of organic solvent, and swelling for 1min to obtain a swollen thin-wall silicone rubber tube;

s2, clamping a medicine core rod on a workbench by using tweezers, putting the medicine core rod and a thin-wall silicone rubber tube into a thin-wall silicone rubber tube, putting the medicine core rod and the thin-wall silicone rubber tube into a stainless steel screen, standing for volatilizing an organic solvent for 2 hours, injecting an adhesive into two ends of the thin-wall silicone rubber tube by using an injector, sealing and plugging, wherein the length of the medical adhesive at the two ends of the thin-wall silicone rubber tube is 1.6mm, and thus obtaining a semi-finished product;

s3, sealing the semi-finished product, indirectly heating the semi-finished product for 5min by using steam of an electric heating steam generator under the rated working pressure of 0.7MPa and the steam temperature of 95 ℃, taking out the semi-finished product and placing the semi-finished product in a stainless steel screen mesh, closing an end cover and the stainless steel screen mesh, opening an air cylinder, driving a pressure head by the air cylinder to extrude the semi-finished product for one time, wherein the pressure applied by the pressure head to the semi-finished product is 0.2kgf/cm²And putting the semi-finished product into a stainless steel plate, sealing the stainless steel plate, putting the sealed stainless steel plate into a medical freezer, and cooling for 5min at the temperature of minus 5 ℃ to obtain the silicon rubber rod.

Referring to fig. 1 and 2, the stainless steel mesh includes a stainless steel mesh body 1, an end cover 2 is hinged to the top of the stainless steel mesh body 1, a pressure head 3 is arranged on one side of the end cover 2 close to the stainless steel mesh body 1, an air cylinder 4 is fixedly arranged on the end cover 2, and an output end of the air cylinder 4 penetrates through the end cover 2 and is fixedly arranged with the pressure head 3;

the organic solvent is n-hexane;

the weight of the medicine core rod is 142mg, the length is 40 +/-1 mm, and the diameter of the medicine core is 1.8 mm;

the length of the thin-wall silicone rubber tube is 50 +/-1 mm, the diameter of the thin-wall silicone rubber tube is 2.2mm, and the thickness of a single-layer wall of the thin-wall silicone rubber tube is 0.15 mm;

the medicine core rod is arranged in the thin-wall silicon rubber tube, the distance between one end of the medicine core rod and the thin-wall silicon rubber tube is 2mm, and the distance between the other end of the medicine core rod and the thin-wall silicon rubber tube is 8 mm.

Example 2

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 1, wherein in the method for loading the drug core rod into the tube S1, the swelling time is 1.5 min; in S2, standing and volatilizing n-hexane for 6 h; in S3, the steam temperature is 100 deg.C, the heating time is 7.5min, the temperature in the medical refrigerator is-2.5 deg.C, and the cooling time is 7.5 min.

Example 3

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 1, wherein in the method for loading the drug core rod into the tube S1, the swelling time is 2 min; in S2, standing and volatilizing n-hexane for 10 hours; in S3, the steam temperature is 105 deg.C, the heating time is 10min, the temperature in the medical refrigerator is 0 deg.C, and the cooling time is 10 min.

Example 4

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 2, in the method for loading the drug core rod into the tube S2, before loading the drug core rod into a thin-wall silicon rubber tube, the drug core rod is cooled for 5min at the temperature of minus 5 ℃ in a medical freezer.

Example 5

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 2, in the method for loading the drug core rod into the tube S2, before loading the drug core rod into a thin-wall silicon rubber tube, the drug core rod is cooled for 7.5min in a medical freezer at the temperature of minus 2.5 ℃.

Example 6

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 2, in the method for loading the drug core rod into the tube S2, before loading the drug core rod into a thin-wall silicon rubber tube, the drug core rod is cooled for 10min at 0 ℃ in a medical freezer.

Example 7

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 2, in the method for loading the drug core rod into the tube S2, before loading the drug core rod into a thin-wall silicon rubber tube, the drug core rod is cooled for 3min in a medical freezer at minus 7.5 ℃.

Example 8

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 2, in the method for loading the drug core rod into the tube S2, before loading the drug core rod into a thin-wall silicon rubber tube, the drug core rod is cooled for 12min at 2.5 ℃ in a medical freezer.

Example 9

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 5 is that the weight of the drug core rod is 143mg, the diameter of the drug core is 1.9mm, the outer diameter of the thin-wall silicon rubber tube is 2.3mm, and the single-layer wall thickness is 0.16 mm.

Example 10

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 5 is that the weight of the drug core rod is 150.5mg, the diameter of the drug core is 2.0mm, the outer diameter of the thin-wall silicon rubber tube is 2.35mm, and the single-layer wall thickness is 0.17 mm.

Example 11

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 5 is that the weight of the drug core rod is 158mg, the diameter of the drug core is 2.1mm, the outer diameter of the thin-wall silicon rubber tube is 2.4mm, and the single-layer wall thickness is 0.18 mm.

Example 12

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 5 is that the weight of the drug core rod is 159mg, the diameter of the drug core is 2.2mm, the outer diameter of the thin-wall silicon rubber tube is 2.5mm, and the single-layer wall thickness is 0.19 mm.

Example 13

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 10 is that the distance between the drug core rod and the end part of the thin-wall silicon rubber tube is 5 +/-1 mm.

Example 14

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 13, wherein the pressure of the extruded semi-finished product is 0.5 bar.

Example 15

A method for loading a drug core rod into a tube, which is different from the method in the embodiment 13, wherein the pressure of the extruded semi-finished product is 1.0 bar.

Example 16

A method for loading a flux-cored bar into a tube, which is different from the method in the embodiment 13, wherein the pressure for extruding the semi-finished product is 1.5 bar.

Example 17

A method for loading a flux-cored bar into a tube, which is different from the method in the embodiment 13, wherein the pressure for extruding the semi-finished product is 1.6 bar.

Example 18

A method for loading a drug core rod into a tube, which is different from the embodiment 15 in that the length of the adhesive at the two ends of the thin-wall silicon rubber tube is 1.8 mm.

Example 19

A method for loading a drug core rod into a tube, which is different from the embodiment 15 in that the length of the adhesive at the two ends of the thin-wall silicon rubber tube is 2.0 mm.

Example 20

A method for loading a drug core rod into a tube, which is different from the embodiment 15 in that the length of the adhesive at the two ends of the thin-wall silicon rubber tube is 2.2 mm.

Example 21

The difference between the method for loading the drug core rod into the tube and the method in the embodiment 15 is that the length of the adhesive at the two ends of the thin-wall silicon rubber tube is 2.4 mm.

Example 22

A method for filling a tube into a medicine core rod, which is different from the embodiment 19 in that an organic solvent is formed by mixing n-hexane and tetrahydrofuran according to the volume ratio of 1:2.

Example 23

A method for filling a tube into a medicine core rod, which is different from the embodiment 19 in that an organic solvent is formed by mixing n-hexane and tetrahydrofuran according to the volume ratio of 1: 2.5.

Example 24

A method for filling a tube into a medicine core rod, which is different from the embodiment 19 in that an organic solvent is formed by mixing n-hexane and tetrahydrofuran according to the volume ratio of 1:3.

Example 25

A method for filling a tube into a medicine core rod, which is different from the embodiment 19 in that an organic solvent is formed by mixing n-hexane and tetrahydrofuran according to the volume ratio of 1: 4.

Example 26

A method for loading a medicine core rod into a tube, which is different from the embodiment 23 in that the material-liquid ratio of a thin-wall silicon rubber tube to an organic solvent is 1: 1.2.

Example 27

A method for loading a medicine core rod into a tube, which is different from the embodiment 23 in that the material-liquid ratio of a thin-wall silicon rubber tube to an organic solvent is 1: 2.1.

Example 28

A method for loading a medicine core rod into a tube, which is different from the embodiment 23 in that the material-liquid ratio of a thin-wall silicon rubber tube to an organic solvent is 1:3.

Example 29

A method for loading a medicine core rod into a tube, which is different from the embodiment 23 in that the material-liquid ratio of a thin-wall silicon rubber tube to an organic solvent is 1: 3.2.

Comparative example

Comparative example 1

A method for loading a core rod into a tube is different from that of example 1 in that in the process S3 for loading the core rod, indirect heating is not performed through steam.

Comparative example 2

A method for loading a core rod into a tube, which is different from the method in example 1, in that a semi-finished product is not extruded in the process of loading the core rod into the tube S3.

Comparative example 3

A method for loading a core rod into a tube, which is different from that of example 1, in that in the process of loading the core rod into the tube S3, the semi-finished product is not cooled.

Comparative example 4

A method for loading a flux core rod into a tube is different from the method in the embodiment 1 in that in the process S3 for loading the flux core rod, steam is not used for indirect heating, and a semi-finished product is not extruded.

Comparative example 5

A method for loading a core rod into a tube is different from that of the embodiment 1 in that in the process S3 for loading the core rod into the tube, steam is not used for indirect heating, and a semi-finished product is not cooled.

Comparative example 6

A method for loading a core rod into a tube is different from that of example 1 in that a semi-finished product is not extruded and the semi-finished product is not cooled in a process S3 for loading the core rod into the tube.

Comparative example 7

A method for loading a core rod into a tube is different from that of the embodiment 1 in that in the process S3 for loading the core rod, the intermediate product is not heated indirectly by steam, the intermediate product is not extruded, and the intermediate product is not cooled.

Performance test

The silicone rubber bars obtained in examples 1 to 29 and comparative examples 1 to 7 were used as test objects, respectively, and the quality standards were as shown in Table 1.

10 parts of each test object are respectively placed in a stainless steel screen mesh at the temperature of 22 ℃ and the relative humidity of 50 percent RH, the air intake is 400m³And under the ventilation condition of/h, observing the position relation change of the medicine core rod and the thin-wall silicon rubber tube when the silicon rubber rod is in 5h and 12h, grading the silicon rubber rod according to the standard of the table 2, and taking an average value of the grading result and recording the average value into the table 3.

TABLE 1 Silicone rubber stick quality standards

TABLE 2 Silicone rubber Bar Scoring standards

TABLE 3 Silicone rubber stick Performance testing

As can be seen from the test data in table 3: the silicone rubber bars prepared in examples 1-29 of the present application meet the standards for microbial limits; at 5h and 12h, the silicone rubber rod scores are both greater than or equal to 1.9, which indicates that the silicone rubber rod prepared by the method of examples 1-29 of the application, the thin-wall silicone rubber tube and the drug core rod are in close contact, which is beneficial to prolonging the contraceptive effect of the long-acting contraceptive implant. Among them, the silicone rubber stick obtained in example 27 of the present application is most preferable.

As is apparent from Table 3, example 1 is different from comparative examples 1 to 7 in the presence or absence of the operation of steam indirect heating, pressing of the semifinished product, and cooling of the semifinished product. In the silicone rubber rod prepared in example 1 of the present application, the silicone rubber rod is 2 in 5 hours, and 1.9 in 12 hours; the silicone rubber bars obtained in comparative examples 1 to 7 had a silicone rubber bar equal to 2 at 5h and less than or equal to 1 at 12 h. Therefore, in the process of loading the medicine core rod, after the steam is indirectly heated, the semi-finished product is extruded and cooled, the thin-wall silicon rubber tube can be promoted to be in close contact with the medicine core rod, and the contraception effect of the long-acting contraception implant can be prolonged.

As can be seen from Table 3, example 1 differs from examples 4-8 in whether the core rod was subjected to a cooling operation before being loaded into the thin-walled silicone rubber tube. In the silicone rubber rod prepared in example 1 of the present application, the silicone rubber rod is 2 in 5 hours, and 1.9 in 12 hours; the silicone rubber bars obtained in examples 4-8 were all equal to 2 at 5h and 2 at 12 h. Therefore, in the process of loading the medicine core rod into the tube, the medicine core rod is cooled for 5-10min at the temperature of-5-0 ℃ before being loaded into the thin-wall silicon rubber tube, so that the thin-wall silicon rubber tube can be promoted to be in close contact with the medicine core rod, and the contraception effect of the long-acting contraception implant can be prolonged.

As is clear from table 3, example 1 is different from examples 9 to 12 in the weight and diameter of the cored bar and the outer diameter and single-layer thickness of the thin silicone rubber tube. In the silicone rubber rod prepared in example 1 of the present application, the silicone rubber rod is 2 in 5 hours, and 1.9 in 12 hours; the silicone rubber bars obtained in examples 9-12 were all equal to 2 at 5h and 2 at 12 h. Therefore, in the process of loading the medicine core rod, the weight of the medicine core rod is 143-158 mg, the diameter is 1.9-2.1mm, the outer diameter of the thin-wall silicon rubber tube is 2.3-2.4mm, and the single-layer wall thickness is 0.16-0.18mm, so that the close contact between the thin-wall silicon rubber tube and the medicine core rod can be promoted, and the contraceptive effect of the long-acting contraceptive implant can be prolonged.

As is apparent from Table 3, example 1 is different from examples 14 to 17 in that the pressing force for pressing the semifinished product is different. In the silicone rubber rod prepared in example 1 of the present application, the silicone rubber rod is 2 in 5 hours, and 1.9 in 12 hours; the silicone rubber bars obtained in examples 14-17 were all equal to 2 at 5h and 2 at 12 h. Therefore, in the process of loading the medicine core rod, the pressure of the extruded semi-finished product is 0.5-1.5bar, so that the thin-wall silicon rubber tube can be promoted to be in close contact with the medicine core rod, and the contraceptive effect of the long-acting contraceptive implant can be prolonged.

As can be seen from Table 3, example 1 differs from examples 18 to 21 in that the lengths of the adhesive at both ends of the thin-walled silicone rubber tube are different. In the silicone rubber rod prepared in example 1 of the present application, the silicone rubber rod is 2 in 5 hours, and 1.9 in 12 hours; the silicone rubber rods obtained in examples 18-21 were all equal to 2 at 5h and 2 at 12 h. Therefore, in the process of loading the medicine core rod, when the length of the adhesive at the two ends of the thin-wall silicon rubber tube is 1.8-2.2mm, the thin-wall silicon rubber tube can be promoted to be in close contact with the medicine core rod, and the contraceptive effect of the long-acting contraceptive implant can be prolonged.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.