1. A composite film with a dry oxygen absorption indicating function is characterized in that a film layer structure of the composite film sequentially comprises a PET layer or a PA layer, an adhesive layer, an aluminum foil layer, an adhesive layer, a PE corona composite layer, a PE dry oxygen absorption indicating layer and a PE heat sealing layer from outside to inside; the PE dry oxygen absorption indicating layer comprises, by weight, 30-70 parts of PE resin and 30-70 parts of a composite dry oxygen absorbent.

2. The composite film with dry oxygen absorption indication function according to claim 1, wherein the composite dry oxygen absorbent comprises calcium oxide, and the particle size of the composite dry oxygen absorbent is 150-250 nm.

3. The composite film with dry oxygen absorption indication function according to claim 2, wherein the composite dry oxygen absorbent further comprises nano reduced iron powder.

4. The composite film with dry oxygen absorption indication function according to claim 3, wherein the thickness ratio of the PE corona composite layer, the PE dry oxygen absorption indication layer and the PE heat sealing layer is 1: (2-4): 1.

5. the composite film with dry oxygen absorption indication function according to claim 4, wherein the thickness of the PET layer or PA layer is 10-30um, the thickness of the aluminum foil layer is 6-60um, and the thickness of the PE corona composite layer is 5-100 um.

6. The composite film with dry oxygen absorption indication function according to claim 5, wherein the adhesive layer is formed by polyurethane two-component glue.

7. The preparation method of the composite film with the dry oxygen absorption indicating function according to claim 6, characterized by comprising the following steps:

s1: preparing a composite dry oxygen absorbent master batch, namely firstly putting the calcium oxide powder, the nano reduced iron powder, the dispersing agent and the PE resin which are in parts by weight of the PE dry oxygen absorbent indicating layer in the claim 1 into an internal mixer for uniform mixing and granulation to prepare the composite dry oxygen absorbent master batch;

s2: the multilayer co-extrusion film blowing method comprises the steps of respectively adding raw materials of a PE corona composite layer, a PE composite drying oxygen absorbent layer and a PE heat sealing layer into different hoppers of an extruder, melting and plasticizing at the temperature of 180 ℃ and 230 ℃, and extruding through a die head; extruding and fusing multiple layers of molten raw materials at an extrusion opening of the die head, and simultaneously blowing up the film;

s3: sequentially compounding the multilayer PE film prepared in the step S2 with an aluminum foil layer and a PET layer/PA layer through an adhesive layer, cutting edges, and rolling to prepare a composite film with a dry oxygen absorption indication function;

s4: and (5) vacuumizing and packaging the composite film prepared in the step S3.

Background

In the pharmaceutical packaging industry, in order to ensure the safety of the pharmaceutical product and prolong the shelf life, the invasion of external oxygen and moisture needs to be blocked. Currently, aluminum foil is the most preferred barrier material for flexible packaging. However, some medicines are extremely sensitive to water, the packaging requirement cannot be met by a pure package with a barrier layer, and for the packaging of some medicines with high requirements, a small package with a desiccant is often placed in the package. The desiccant which is singly added in small packages needs to be added at the same time and is singly packaged by adopting a special packaging film, so that the production cost is high; secondly, in the process of medicine packaging, the independently packaged drying agents need to be additionally put in an independent process, so that the work load of medicine packaging is increased, and the independently packaged drying agents also have the risk of eating by mistake; in addition, in the medicine package, a high-barrier material is used, so that the propagation of microorganisms and the oxidation of contents caused by the permeation of gases such as oxygen can be prevented, and the shelf life of the medicine is prolonged.

Therefore, materials with the blocking function, the water absorption function and the oxygen absorption function are overlapped together, so that the packaging bag can absorb water molecules in the packaging bag, block external water vapor and absorb oxygen permeating into the packaging bag, oxidation and denaturation of packaged medicines are avoided, and the packaging bag is very meaningful.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide the composite film with the dry oxygen absorption indicating function, which can monitor the conditions of water vapor and oxygen in the packaging bag, reduce the packaging cost and procedures, effectively block the water vapor and prolong the shelf life of the packaged contents.

In order to achieve the purpose, the technical scheme of the invention is to design a composite film with a dry oxygen absorption indicating function, wherein a film layer structure of the composite film sequentially comprises a PET (polyethylene terephthalate) layer or a PA (polyamide) layer, an adhesive layer, an aluminum foil layer, an adhesive layer, a PE (polyethylene) corona composite layer, a PE dry oxygen absorption indicating layer and a PE heat sealing layer from outside to inside; the PE dry oxygen absorption indicating layer comprises, by weight, 30-70 parts of PE resin and 30-70 parts of a composite dry oxygen absorbent. According to the composite film, the aluminum foil layer is arranged, the PE dry oxygen absorption indicating layer is arranged on the outer side of the PE heat sealing layer, the composite dry oxygen absorption agent capable of developing color by absorbing water is added into the PE dry oxygen absorption indicating layer, and after the composite dry oxygen absorption agent absorbs water, the color of the packaging film changes, so that the conditions of water vapor and oxygen in the packaging bag can be monitored conveniently; in addition, the composite film is used for packaging medicines, moisture can be effectively blocked, moisture permeating from the outside can be continuously absorbed, the dryness of packaged contents is improved, the quality guarantee period of the packaged contents is prolonged, and the packaging cost can be reduced and the packaging process can be simplified by replacing a drying agent with the packaging film.

The preferable technical scheme is that the composite dry oxygen absorbent comprises calcium oxide, and the particle size of the composite dry oxygen absorbent is 150-250 nm. The calcium oxide is white, after being mixed with PE in the film making process, the calcium oxide is in an impurity state, and is in a light yellow color in the inner layer of the composite film after being reflected by light rays, and after the calcium oxide absorbs water, the whiteness is increased, so that the internal representation of the packaging film is white, and the water absorption effect of the composite film is further improved; and the calcium oxide has good water absorption effect, low cost and easy obtaining, and further reduces the manufacturing cost of the composite membrane.

The further preferable technical scheme is that the composite dry oxygen absorbent also comprises nano reduced iron powder. The PE dry oxygen absorption indicating layer is simultaneously added with the nano reduced iron powder, the nano reduced iron powder reacts with oxygen permeating from the outside or oxygen packaged in the PE dry oxygen absorption indicating layer to generate iron red ferric oxide, oxygen can be blocked from the outside, oxygen in the PE dry oxygen absorption indicating layer can be absorbed, and the possibility of oxidative denaturation of medicines is reduced.

The further preferred technical scheme is that the thickness ratio of the PE corona composite layer, the PE dry oxygen absorption indicating layer and the PE heat sealing layer is 1: (2-4): 1. the water absorption time of the PE dry oxygen absorption indicating layer is further controlled by controlling the thicknesses of the PE corona composite layer, the PE dry oxygen absorption indicating layer and the PE heat sealing layer, so that the composite film can be selected and regulated between long-acting water absorption and short-acting water absorption.

The further preferred technical scheme is that the thickness of the PET layer or the PA layer is 10-30um, the thickness of the aluminum foil layer is 6-60um, and the thickness of the PE corona composite layer is 5-100 um.

The preferable technical scheme is that the adhesive layer is formed by polyurethane bi-component glue. The PE corona composite layer, the PET layer or the PA layer are connected with the aluminum foil layer through the adhesive, and due to the fact that the surface of the aluminum foil is provided with a certain number of fine pores, the polyurethane bi-component glue is compounded on the surface of the aluminum foil, and the glue is filled in the pores of the aluminum foil, so that the strength of the aluminum foil is improved, and the blocking performance of the aluminum foil is also improved.

The invention also discloses a preparation method of the composite membrane with the dry oxygen absorption indicating function, which comprises the following steps:

s1: preparing a composite dry oxygen absorbent master batch, firstly putting the calcium oxide powder, the nano reduced iron powder, the dispersing agent such as EBS (ethylene bis stearamide) and the PE resin which are in parts by weight of the PE dry oxygen absorbent indicating layer in the claim 1 into an internal mixer for uniform mixing and granulation to prepare the composite dry oxygen absorbent master batch;

s2: the multilayer co-extrusion film blowing method comprises the steps of respectively adding raw materials of a PE corona composite layer, a PE composite drying oxygen absorbent layer and a PE heat sealing layer into different hoppers of an extruder, melting and plasticizing at the temperature of 180 ℃ and 230 ℃, and extruding through a die head; extruding and fusing multiple layers of molten raw materials at an extrusion opening of the die head, and simultaneously blowing up the film;

s3: sequentially compounding the multilayer PE film prepared in the step S2 with an aluminum foil layer and a PET layer/PA layer through an adhesive layer, cutting edges, and rolling to prepare a composite film with a dry oxygen absorption indication function;

s4: and (5) vacuumizing and packaging the composite film prepared in the step S3.

In the preparation method, the calcium oxide, the nano reduced iron powder and the PE are mixed and granulated to prepare the composite dry oxygen absorbent master batch, and finally the master batch is blended with other components and extruded to form a film, so that the dispersibility of the composite dry oxygen absorbent in the whole PE dry oxygen absorption indicating layer is improved, and the water absorption and color development effects of the composite film are further improved.

The invention has the advantages and beneficial effects that: the composite film with the dry oxygen absorption indication function can monitor the conditions of water vapor and oxygen in the packaging bag, reduce the packaging cost and procedures, effectively reduce the water vapor and oxygen in the package, and prolong the shelf life of the packaged contents. According to the composite film, the aluminum foil layer is arranged, the PE dry oxygen absorption indicating layer is arranged on the outer side of the PE heat sealing layer, the composite dry oxygen absorption agent capable of developing color by absorbing water is added into the PE dry oxygen absorption indicating layer, and after the composite dry oxygen absorption agent absorbs water, the color of the packaging film changes, so that the water absorption condition in the packaging bag is monitored conveniently; in addition, the composite film is adopted to package the medicine, moisture can be effectively blocked, moisture permeating from the outside can be continuously absorbed, the dryness of the packaged content is improved, the quality guarantee period of the packaged content is prolonged, and the packaging cost can be reduced and the packaging process can be simplified by adopting the packaging film to replace a drying agent; the calcium oxide is white, after being mixed with PE in the film making process, the calcium oxide is in an impurity state, and is in a light yellow color in the inner layer of the composite film after being reflected by light rays, and after the calcium oxide absorbs water, the whiteness is increased, so that the internal representation of the packaging film is white, and the water absorption effect of the composite film is further improved; the calcium oxide has good water absorption effect, low cost and easy obtaining, and the manufacturing cost of the composite membrane is further reduced; the PE dry oxygen absorption indicating layer is simultaneously added with the nano reduced iron powder, the nano reduced iron powder reacts with oxygen permeating from the outside or oxygen packaged in the PE dry oxygen absorption indicating layer to generate iron red ferric oxide, oxygen can be blocked from the outside, the oxygen in the PE dry oxygen absorption indicating layer can be absorbed, and the possibility of oxidative denaturation of medicines is reduced; in the preparation method, the calcium oxide, the nano reduced iron powder and the PE are mixed and granulated to prepare the composite dry oxygen absorbent master batch, and finally the master batch is blended with other components and extruded to form a film, so that the dispersibility of the composite dry oxygen absorbent in a PE dry oxygen absorption indicating layer is improved, and the water absorption and oxygen absorption color development effects of the composite film are further improved.

Drawings

Fig. 1 is a schematic structural diagram of a composite film with a dry oxygen absorption indicating function according to the present invention.

In the figure: 1. a PET layer or a PA layer; 2. an adhesive layer; 3. an aluminum foil layer; 4. an adhesive layer; 5. PE corona composite layer; 6. PE dry oxygen absorption indicating layer; 7. and (4) a PE heat sealing layer.

Detailed Description

The following description of the embodiments of the present invention will be made with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.

Example 1

As shown in fig. 1, the invention is a composite film with a dry oxygen inhalation indicating function, and the film layer structure of the composite film sequentially comprises a PET layer or a PA layer 1, an adhesive layer 2, an aluminum foil layer 3, an adhesive layer 4, a PE corona composite layer 5, a PE dry oxygen inhalation indicating layer 6, and a PE heat sealing layer 7 from outside to inside; the PE dry oxygen absorption indicating layer comprises 50 parts of PE and 50 parts of calcium oxide in parts by weight.

The thickness on PET layer or PA layer is 20um, and the aluminium foil layer thickness is 30um, and the thickness of PE corona composite layer is 50um, the thickness 17um on the dry oxygen uptake instruction layer of PE, thickness between the PE heat-seal layer is 17 um.

The adhesive layer is formed by polyurethane bi-component glue, the polyurethane bi-component glue comprises a main agent and a curing agent, and the mixing mass ratio of the main agent to the curing agent is 20: 1; the main agent is Adcote 502S glue of Dows company, and the curing agent is Catalyst F curing agent. Or the polyurethane bi-component glue comprises a main agent and a curing agent, wherein the mixing mass ratio of the main agent to the curing agent is 50: 1; the main agent is UK 3640 glue of Hangao company, and the curing agent is UK 6800 curing agent.

A preparation method of a composite film with a dry oxygen absorption indicating function comprises the following steps: the multilayer co-extrusion film blowing method comprises the steps of respectively adding raw materials of a PE corona composite layer, a PE composite drying oxygen absorbent layer and a PE heat sealing layer into different hoppers of an extruder, melting and plasticizing at the temperature of 180 ℃ and 230 ℃, and extruding through a die head; extruding and fusing multiple layers of molten raw materials at an extrusion opening of the die head, and simultaneously blowing up the film; and (3) sequentially compounding the prepared multilayer co-extrusion blown film with an aluminum foil layer and a PET (polyethylene terephthalate) layer/PA (polyamide) layer through an adhesive layer, cutting edges, rolling, vacuumizing and packaging to prepare the composite film with the dry oxygen absorption indication function.

Example 2

Example 2 differs from example 1 in that the PE dry oxygen absorbing indicator layer comprises 50 parts by weight of PE and 40 parts by weight of calcium oxide.

Example 3

Example 3 differs from example 2 in that the PE dry oxygen absorbing indicator layer comprises, in parts by weight, 50 parts of PE, 60 parts of calcium oxide

Example 4

Example 4 is different from example 1 in that the composite dry oxygen absorbent includes 25 parts of calcium oxide and 25 parts of nano reduced iron powder.

Example 5

The difference between the embodiment 5 and the embodiment 4 is that the calcium oxide powder, the nanometer reduced iron powder and 20 parts of PE particles are uniformly mixed and granulated to prepare the composite dry oxygen absorbent master batch, and then the raw materials of the PE corona composite layer, the PE composite dry oxygen absorbent layer and the PE heat sealing layer are respectively added into different hoppers of an extruder, melted and plasticized at the temperature of 180 ℃ and 230 ℃ and extruded through a die head; extruding and fusing multiple layers of molten raw materials at an extrusion opening of the die head, and simultaneously blowing up the film; the obtained multilayer PE film is sequentially compounded with an aluminum foil layer and a PET layer/PA layer through an adhesive layer, and the composite film with the dry oxygen absorption indication function is prepared through edge cutting, rolling and vacuum packaging.

Example 6

Example 6 differs from example 5 in that the PE dry oxygen absorbing indicator layer has a thickness of 12um and the PE heat seal layer has a thickness of 12 um.

Example 7

Example 7 differs from example 5 in that the PE dry oxygen absorbing indicator layer is 25um and the PE heat seal layer is 25 um.

The composite membranes prepared in the above embodiments are subjected to performance detection, and the detection results are as follows:

the foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the technical principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.