1. The utility model provides an early type 2 diabetes hair follicle tissue protein molecular marker is with detect reagent box, includes shell (1), backup pad (2), baffle (3), fixed block (4) and reagent pipe (23), its characterized in that: standing groove (18) have been seted up to shell (1) one side outer wall, shell (1) inner wall one side laminating is fixed with heat preservation cotton (11), spout (13) have all been seted up to shell (1) inner wall both sides symmetry, shell (1) inside is provided with backup pad (2), connecting plate (22) are installed to backup pad (2) upper end outer wall one side.

2. The detection kit for the early type 2 diabetes mellitus hair follicle tissue protein molecular marker according to claim 1, characterized in that: screw holes (19) are formed in the outer wall of one side of the shell (1) and are distributed in parallel at equal intervals, and the screw holes (19) are distributed at the upper end and the lower end of the placing groove (18);

the novel fixing baffle plate is characterized in that a baffle plate (3) is arranged inside the placing groove (18), movable holes (31) which are distributed in parallel at equal intervals are formed in the outer wall of one side of the baffle plate (3), bolts (32) are arranged inside the movable holes (31), the bolts (32) penetrate through the movable holes (31) to be meshed with the screw holes (19), and the purpose of fixing the baffle plate (3) is achieved through the meshing force between the bolts (32) and the screw holes (19).

3. The detection kit for the early type 2 diabetes mellitus hair follicle tissue protein molecular marker according to claim 1, characterized in that: the outer wall of the lower end of the supporting plate (2) is provided with first springs (12) distributed in a rectangular array, the supporting plate (2) is elastically connected with the lower end of the inner wall of the shell (1) through the first springs (12), and the first springs (12) achieve the purpose of pushing the supporting plate (2) and the connecting plate (22) to move;

the outer walls of two sides of the supporting plate (2) are symmetrically provided with sliding blocks (21), the sliding blocks (21) are slidably arranged in the sliding grooves (13), and the sliding blocks (21) and the sliding grooves (13) ensure the vertical movement stability of the supporting plate (2) and the connecting plate (22);

backup pad (2) and connecting plate (22) are inside all to set up equidistance parallel distribution's spacing groove (25), reagent pipe (23) have been placed to spacing groove (25) inside, end cap (24) are installed to reagent pipe (23) upper end outer wall one side joint, end cap (24) have reached the purpose of blockking up reagent pipe (23), avoid the inside object of reagent pipe (23) to flow.

4. The detection kit for the early type 2 diabetes mellitus hair follicle tissue protein molecular marker according to claim 1, characterized in that: a cover plate (16) is arranged on one side of the outer wall of the upper end of the shell (1), and a handle (17) is arranged on one side of the outer wall of the upper end of the cover plate (16);

cutting ferrule (14) are installed to the equal symmetry in shell (1) both sides outer wall upper end, buckle (15) are installed in cutting ferrule (14) inside rotation, buckle (15) and apron (16) joint each other, the clamping force that buckle (15) produced has reached the purpose of fixed apron (16), has guaranteed apron (16) positional stability.

5. The detection kit for the early type 2 diabetes mellitus hair follicle tissue protein molecular marker according to claim 1, characterized in that: the outer wall of the upper end of the connecting plate (22) is provided with fixing blocks (4) which are distributed in parallel at equal intervals, a movable groove (41) is formed in each fixing block (4), and a connecting rod (43) is arranged in each movable groove (41);

a second spring (42) is arranged on one side of the inner wall of the movable groove (41), and the connecting rod (43) is connected with the spring on one side of the inner wall of the movable groove (41) through the second spring (42);

connecting rod (43) deviate from movable groove (41) one end outer wall and install splint (44), splint (44) distribute in reagent pipe (23) both sides, and splint (44) contact with reagent pipe (23), splint (44) have reached the purpose of centre gripping reagent pipe (23) through the thrust that second spring (42) produced, have guaranteed the stability of reagent pipe (23).

Background

Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The chronic presence of hyperglycemia results in chronic damage to, and dysfunction of, various tissues, particularly the eye, kidney, heart, blood vessels, nerves, and hair follicle tissue, including hair, pores, and hair follicles. Hair is composed of a keratin protein, which is an attachment to the skin, and the detection kit is a kit for containing chemical reagents for detecting chemical components, drug residues, virus species, and the like.

Through mass search, a polypeptide marker for early diagnosis of diabetes, a detection kit and a method thereof are found, which are typical in a kit device in the prior art and disclosed as CN112924608A, the invention provides a method and a kit for quantitatively detecting endogenous polypeptide in serum by using Multiple Reaction Monitoring (MRM), and the content of the polypeptide marker GVLSSRQLGLPGPPDVPDHAA in human serum is quantitatively determined by using the reagent and the method, and then a marker variable and a determined cut-off value are calculated based on a binary logistic regression equation for early warning or diagnosis of diabetes. The kit and the detection method have the advantages of good stability, high specificity and potential for clinical popularization.

Current kit is in the use, places the reagent pipe in that the shell is inside to deposit usually, and when the staff took the reagent pipe from the shell is inside, caused collision each other between the reagent pipe easily to can lead to reagent pipe damaged phenomenon to appear, thereby influence reagent pipe normal use, and because reagent pipe has the pipe diameter size to divide, the spacing groove aperture of injecing can not adapt to different reagent pipes, influences reagent pipe's fixed stability.

Disclosure of Invention

The invention aims to provide a detection kit for an early type 2 diabetes mellitus hair follicle tissue protein molecular marker, which has the advantages of improving the fixation stability of a reagent tube and facilitating the taking of the reagent tube by workers, and solves the problems of poor fixation stability of the reagent tube and inconvenience for the workers to take the reagent tube.

In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides an early type 2 diabetes hair follicle tissue protein detection kit for molecular marker, includes shell, backup pad, baffle, fixed block and reagent pipe, the standing groove has been seted up to shell one side outer wall, shell inner wall one side laminating is fixed with the heat preservation cotton, the spout has been seted up to shell inner wall both sides equal symmetry, the inside backup pad that is provided with of shell, the connecting plate is installed to backup pad upper end outer wall one side.

Preferably, the outer wall of one side of the shell is provided with screw holes which are distributed in parallel at equal intervals, and the screw holes are distributed at the upper end and the lower end of the placing groove;

the standing groove is internally provided with a baffle, the outer wall of one side of the baffle is provided with movable holes which are distributed in parallel at equal intervals, the inner parts of the movable holes are provided with bolts, the bolts penetrate through the movable holes to be meshed with the screw holes, and the purpose of fixing the baffle is achieved by the meshing force between the bolts and the screw holes.

Preferably, the outer wall of the lower end of the supporting plate is provided with first springs distributed in a rectangular array, the supporting plate is elastically connected with the lower end of the inner wall of the shell through the first springs, and the first springs achieve the purpose of pushing the supporting plate and the connecting plate to move;

the sliding blocks are symmetrically arranged on the outer walls of the two sides of the supporting plate and are slidably arranged in the sliding grooves, and the sliding blocks and the sliding grooves ensure the vertical movement stability of the supporting plate and the connecting plate;

the utility model discloses a reagent tube, including backup pad, connecting plate, limiting groove, end cap, stopper, reagent tube upper end outer wall, the inside spacing groove of equidistance parallel distribution has all been seted up to backup pad and connecting plate, reagent tube has been placed to the spacing inslot portion, the end cap is installed to reagent tube upper end outer wall one side joint, the end cap has reached the purpose of blockking up reagent tube, avoids the inside object of reagent tube to flow.

Preferably, a cover plate is arranged on one side of the outer wall of the upper end of the shell, and a handle is installed on one side of the outer wall of the upper end of the cover plate;

the clamping sleeve is symmetrically arranged at the upper end of the outer wall of the two sides of the shell, the clamping buckle is rotatably arranged in the clamping sleeve, the clamping buckle and the cover plate are clamped mutually, the clamping force generated by the clamping buckle achieves the aim of fixing the cover plate, and the position stability of the cover plate is ensured.

Preferably, the outer wall of the upper end of the connecting plate is provided with fixed blocks which are distributed in parallel at equal intervals, the inner part of each fixed block is provided with a movable groove, and a connecting rod is arranged in each movable groove;

a second spring is arranged on one side of the inner wall of the movable groove, and the connecting rod is connected with the spring on one side of the inner wall of the movable groove through the second spring;

the connecting rod deviates from movable groove one end outer wall and installs splint, splint distribute in reagent pipe both sides, and splint and reagent pipe contact, splint have reached the purpose of centre gripping reagent pipe through the thrust that the second spring produced, have guaranteed the stability of reagent pipe.

Compared with the prior art, the invention has the following beneficial effects:

1. according to the reagent tube taking device, the first spring, the sliding groove and the supporting plate are arranged, so that the effect of facilitating a worker to take the reagent tube is achieved, the worker breaks the buckle to separate the buckle from the cover plate, the supporting plate is pushed by the elastic force of the first spring to move upwards until the sliding block moves to the upper end of the sliding groove, the working height of the connecting plate is improved, the upper end of the reagent tube is moved out of the shell, the worker can take the reagent tube conveniently, the accuracy of taking the reagent tube by the worker is improved, the probability of collision between the reagent tubes is reduced, the completeness of the reagent tube is guaranteed, and the stability of the working positions of the supporting plate and the connecting plate is guaranteed through the elastic force of the first spring.

2. According to the reagent tube fixing device, the second spring, the connecting rod and the clamping plate are arranged, so that the effect of improving the stability of the reagent tube is achieved, when the reagent tube is positioned in the limiting groove, the limiting groove ensures the stability of the reagent tube positioned in the connecting plate, the connecting rod pushes the clamping plate to clamp the reagent tube through the elasticity of the second spring, the position stability of the reagent tube is improved, the device can be adapted to reagent tubes with different tube diameters, and the applicability of the device is improved.

Drawings

FIG. 1 is a schematic cross-sectional view of the housing structure of the present invention;

FIG. 2 is a schematic top view of a connecting plate structure according to the present invention;

FIG. 3 is an enlarged view of the structure A of FIG. 1 according to the present invention;

FIG. 4 is an enlarged view of the structure B in FIG. 1 according to the present invention.

In the figure: 1. a housing; 11. heat preservation cotton; 12. a first spring; 13. a chute; 14. a card sleeve; 15. buckling; 16. a cover plate; 17. a handle; 18. a placement groove; 19. a screw hole; 2. a support plate; 21. a slider; 22. A connecting plate; 23. a reagent tube; 24. a plug; 25. a limiting groove; 3. a baffle plate; 31. a movable hole; 32. A bolt; 4. a fixed block; 41. a movable groove; 42. a second spring; 43. a connecting rod; 44. and (4) clamping the plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be configured in a specific orientation, and operate, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Referring to fig. 1 to 4, the present invention provides two embodiments:

the first embodiment is as follows: a detection kit for early type 2 diabetes mellitus hair follicle tissue protein molecular markers comprises a shell 1, a supporting plate 2, a baffle 3, a fixed block 4 and a reagent tube 23, wherein a placing groove 18 is formed in the outer wall of one side of the shell 1, heat preservation cotton 11 is fixedly attached to one side of the inner wall of the shell 1, the purpose of preserving heat inside the shell 1 is achieved by the heat preservation cotton 11, sliding grooves 13 are symmetrically formed in two sides of the inner wall of the shell 1, the supporting plate 2 is arranged inside the shell 1, a connecting plate 22 is mounted on one side of the outer wall of the upper end of the supporting plate 2, screw holes 19 which are equidistantly and parallelly distributed are formed in the outer wall of one side of the shell 1, and the screw holes 19 are distributed at the upper end and the lower end of the placing groove 18;

the inside baffle 3 that is provided with of standing groove 18, baffle 3 has reached the purpose of sheltering from standing groove 18, the staff dismantles behind the baffle 3, can place the ice bag to the inside lower extreme of shell 1 through standing groove 18, the ice bag has reached the purpose that reduces the inside temperature of shell 1, it is impaired to avoid the inside object of reagent pipe 23 to receive the high temperature influence, movable hole 31 of equidistance parallel distribution is seted up to 3 one side outer walls of baffle, the inside bolt 32 that is provided with of movable hole 31, bolt 32 runs through movable hole 31 and meshes with screw 19 mutually, engaging force between bolt 32 and the screw 19, the purpose of fixed stop 3 has been reached.

The outer wall of the lower end of the supporting plate 2 is provided with first springs 12 distributed in a rectangular array, the supporting plate 2 is elastically connected with the lower end of the inner wall of the shell 1 through the first springs 12, the first springs 12 achieve the purpose of pushing the supporting plate 2 and the connecting plate 22 to move, and the stability of the working positions of the supporting plate 2 and the connecting plate 22 is guaranteed through the elasticity of the first springs 12;

the outer walls of two sides of the supporting plate 2 are symmetrically provided with the sliding blocks 21, the sliding blocks 21 are slidably arranged in the sliding grooves 13, the sliding blocks 21 and the sliding grooves 13 ensure the vertical movement stability of the supporting plate 2 and the connecting plate 22, a worker breaks the buckles 15 off the buckles 15 and the cover plate 16, the supporting plate 2 is pushed by the elastic force of the first spring 12 to move upwards until the sliding blocks 21 move to the upper end of the sliding grooves 13, so that the working height of the connecting plate 22 is improved, the upper end of the reagent tube 23 is moved out of the shell 1, the reagent tube 23 can be conveniently taken by the worker, the accuracy of taking the reagent tube 23 by the worker is improved, the collision probability among the reagent tubes 23 is reduced, and the integrity of the reagent tube 23 is ensured;

the inside spacing groove 25 that all sets up equidistance parallel distribution of backup pad 2 and connecting plate 22, reagent pipe 23 has been placed to spacing groove 25 inside, and end cap 24 is installed to 23 outer wall one side joints in the reagent pipe, and end cap 24 has reached the purpose that blocks up reagent pipe 23, avoids the inside object of reagent pipe 23 to flow.

A cover plate 16 is arranged on one side of the outer wall of the upper end of the shell 1, a handle 17 is arranged on one side of the outer wall of the upper end of the cover plate 16, the cover plate 16 achieves the purpose of shielding the shell 1, and a worker can conveniently drive the shell 1 to move through the handle 17;

the clamping sleeves 14 are symmetrically arranged at the upper ends of the outer walls of the two sides of the shell 1, the buckles 15 are rotatably arranged in the clamping sleeves 14, the buckles 15 are clamped with the cover plate 16, the clamping force generated by the buckles 15 achieves the purpose of fixing the cover plate 16, and the position stability of the cover plate 16 is ensured.

Example two: a detection kit for an early type 2 diabetes mellitus hair follicle tissue protein molecular marker comprises a shell 1, a supporting plate 2, a baffle 3, a fixed block 4 and a reagent tube 23, wherein a placing groove 18 is formed in the outer wall of one side of the shell 1, heat preservation cotton 11 is fixedly attached to one side of the inner wall of the shell 1 in an attaching mode, sliding grooves 13 are symmetrically formed in two sides of the inner wall of the shell 1, the supporting plate 2 is arranged inside the shell 1, a connecting plate 22 is mounted on one side of the outer wall of the upper end of the supporting plate 2, first springs 12 distributed in a rectangular array mode are arranged on the outer wall of the lower end of the supporting plate 2, the supporting plate 2 is elastically connected with the lower end of the inner wall of the shell 1 through the first springs 12, and the first springs 12 achieve the purpose of pushing the supporting plate 2 and the connecting plate 22 to move;

the outer walls of the two sides of the supporting plate 2 are symmetrically provided with sliding blocks 21, the sliding blocks 21 are slidably arranged in the sliding grooves 13, and the sliding blocks 21 and the sliding grooves 13 ensure the vertical movement stability of the supporting plate 2 and the connecting plate 22;

the inside spacing groove 25 that all sets up equidistance parallel distribution of backup pad 2 and connecting plate 22, reagent pipe 23 has been placed to spacing groove 25 inside, and end cap 24 is installed to 23 outer wall one side joints in the reagent pipe, and end cap 24 has reached the purpose that blocks up reagent pipe 23, avoids the inside object of reagent pipe 23 to flow.

A cover plate 16 is arranged on one side of the outer wall of the upper end of the shell 1, and a handle 17 is arranged on one side of the outer wall of the upper end of the cover plate 16;

the clamping sleeves 14 are symmetrically arranged at the upper ends of the outer walls of the two sides of the shell 1, the buckles 15 are rotatably arranged in the clamping sleeves 14, the buckles 15 are clamped with the cover plate 16, the clamping force generated by the buckles 15 achieves the purpose of fixing the cover plate 16, and the position stability of the cover plate 16 is ensured.

The outer wall of the upper end of the connecting plate 22 is provided with fixing blocks 4 which are equidistantly distributed in parallel, a movable groove 41 is formed in each fixing block 4, and a connecting rod 43 is arranged in each movable groove 41;

a second spring 42 is arranged on one side of the inner wall of the movable groove 41, and the connecting rod 43 is connected with the spring on one side of the inner wall of the movable groove 41 through the second spring 42;

connecting rod 43 deviates from 41 one end outer walls in movable groove and installs splint 44, splint 44 distributes in reagent pipe 23 both sides, and splint 44 contacts with reagent pipe 23, splint 44 has reached the purpose of centre gripping reagent pipe 23 through the thrust that second spring 42 produced, the stability of reagent pipe 23 has been guaranteed, when reagent pipe 23 is located spacing groove 25 inside, spacing groove 25 has guaranteed that reagent pipe 23 is located the inside stability of connecting plate 22, connecting rod 43 promotes splint 44 through second spring 42's elasticity and has carried reagent pipe 23, thereby the positional stability of reagent pipe 23 has been improved, guarantee that equipment can adapt to the reagent pipe 23 of different pipe diameters, the suitability of equipment has been improved.

The working principle is as follows: the staff breaks off with the fingers and thumb buckle 15, makes buckle 15 break away from with apron 16 mutually, and first spring 12 elasticity promotes backup pad 2 rebound, moves to spout 13 upper end until slider 21 to the working height of connecting plate 22 has been improved, makes reagent pipe 23 upper end shift out inside shell 1, and the staff of being convenient for takes reagent pipe 23, improves the accuracy that the staff took reagent pipe 23, and through first spring 12 elasticity, has guaranteed backup pad 2 and connecting plate 22's operating position stability.

When the reagent tube 23 is located in the limiting groove 25, the limiting groove 25 ensures the stability of the reagent tube 23 in the connecting plate 22, and the connecting rod 43 pushes the clamping plate 44 to clamp the reagent tube 23 through the elastic force of the second spring 42, thereby improving the position stability of the reagent tube 23.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.